DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stj and Cachd1

DIOPT Version :9

Sequence 1:	NP_001246303.1	Gene:	stj / 36526	FlyBaseID:	FBgn0261041	Length:	1271	Species:	Drosophila melanogaster
Sequence 2:	NP_932154.1	Gene:	Cachd1 / 320508	MGIID:	2444177	Length:	1288	Species:	Mus musculus

Alignment Length:	1068	Identity:	219/1068 - (20%)
Similarity:	379/1068 - (35%)	Gaps:	312/1068 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LVCLAPCVNLQPAENINYNLVH------SWADKLGMELFHLGDFITRRKEVQESFKDAKVVSRNG 78
            |:||..|..|....:.:::::.      |...:|..|  .||  :...:.:..|....:.:| ||
Mouse    36 LLCLVACWILGAVADADFSILDEAQVLASQMRRLAAE--ELG--VVTMQRIFNSLVYTEKIS-NG 95

  Fly    79 ASIVDSMAKEIEMMMDLKVSAVRRIMDTAENTALSHQNDMADKMFSYYSAKEMLEPGDPVPPIPT 143
            .|.|..:||:|....:..:..|.|.....|.:..:|
Mouse    96 ESEVQQLAKKIREKFNRYLDVVNRNKQVVEASYTAH----------------------------- 131

  Fly   144 PAPDMDKDIGEPLIYVQPKVVVLEPRPEF---HNTPVNFSVSSVHVPVNVFDRAPDVIKAIQWSE 205
                    :..||..:|....:.....||   .||.|:.:||...:...|..|      |.....
Mouse   132 --------LTSPLTAIQDCCTIPPSMMEFDGNFNTNVSRTVSCDRLSTTVNSR------AFNPGR 182

  Fly   206 NLDQIFRDNYKNDPTLSWQFFGSSTGFMRQFPASKWRKDVPVDLYDCRLRSWYMEAA-TSPKDIV 269
            :|:.:..||.|::|.:.||:|.|..|....|||.|:|..   ..|:.|.|..|:... ...|.||
Mouse   183 DLNSVLADNLKSNPGIKWQYFSSEEGIFTVFPAHKFRCK---GSYEHRSRPIYVSTVRPQSKHIV 244

  Fly   270 ILMDGSGSMLGQRLDIAKHVVNTILDTLGTNDFVNIFTFDKEV--SPVVPCFEDTLIQANLGNIR 332
            :::|...|:...:|.|||.....||..:..:|.:::.|....|  ..:..|::..|..|.....|
Mouse   245 VILDHGASVTDTQLQIAKDAAQVILSAIDEHDKISVLTVADAVRTCSLDQCYKTYLSPATSETKR 309

  Fly   333 ELKEGIELFRPK-SIANYTAALTKAFELLEETKLSSRGAQCNQAIMII--------GDGAPEN-- 386
            ::...:...:|. |...:.....:||:|:..|..|:| .|.|..::||        .|.:.|:
Mouse   310 KMSTFVSSVKPSDSPTQHAVGFHRAFQLIRSTSNSTR-FQANTDMVIIYLSAGITSKDSSEEDKK 373

  Fly   387 ------NREVFELHNWRDPPYKPVRVFTYLIG-------KEVANWDDIRWMACENQGYYVHLSDT 438
                  |.|...|:|       .|.:.||.:.       ||:|   .:|.:|.:|.|.|.....|
Mouse   374 ATLRVINEENGFLNN-------SVMILTYALMNDGVTGLKELA---FLRDLAEQNSGKYGIPDRT 428

  Fly   439 AEVREMVLNYIPVMARPLVLGRHDHPVIWSQVYADIEDTKLSDYLWDINQCEYQKADVLEYWQVH 503
            |         :||:...:::                           :||....:..|
Mouse   429 A---------LPVIKGSMMV---------------------------LNQLSNLETTV------- 450

  Fly   504 DRMLEPSEMHRRKYRRMKETWNQPVDSNVYQFMTTVSMPIYDRRENALINLTTDINPAAKINLQV 568
                      .|.|..:.   |:.:|..|:      |:|..|...:.||  .|...|....||
Mouse   451 ----------GRFYTNLP---NRMIDEAVF------SLPFSDEMGDGLI--MTVSKPCYFGNL-- 492

  Fly   569 TRIANILGVAGTDVPINEIKKLLSPFTLGVNGYAFIVTNNGYVLFHPDF-RPIFQGYILKPAYNS 632
                 :||:.|.||.:..|.:.::.:...:..|.|::.:.||.|.||.. ||    |:|......
Mouse   493 -----LLGIVGVDVNLAYILEDVTYYQDSLASYTFLIDDKGYTLMHPSLTRP----YLLSEPPLH 548

  Fly   633 VDMIEVELLDDDRPARDFNPVLMTIRDSIINQSTGSKWMLV------KNHFDEMKRVAR--VKRQ 689
            .|:|..|.:          |....:|.:|::...||:.:.|      ..|.::::...:  ....
Mouse   549 TDIIHYENI----------PKFELVRQNILSLPLGSQIITVPVNSSLSWHINKLRETGKEAYNVS 603

  Fly   690 YYWTAIKKTPFTL--VISYPEQYGVSHMDIRADQEIHRISIKG-TNLRSVFSGKRWKIHPDWLFC 751
            |.|..::.|.|.|  |:..||                 |.:|. .||.:|
Mouse   604 YAWKMVQDTSFILCIVVIQPE-----------------IPVKQLKNLNTV--------------- 636

  Fly   752 KHSNRTFKTPEIELLYF-LERMSEPGWRWPGSRSA-------MPPEHAAAMFSNNSSTGRYPSIN 808
                     |..:|||. |:.:.:|        ||       ...|....|.|..|.:..|..::
Mouse   637 ---------PSSKLLYHRLDLLGQP--------SACLHFKQLATLESPTVMLSAGSFSSPYEHLS 684

  Fly   809 EKESYYCDRQLMQALVFDARVTGWFSNNT--------SFNSKDDKGTSASSPIA----VLMGLLP 861
            :.|:    :::::      ..|.:.|:||        .|:.:::  ..|:|.:.    ..|.:..
Mouse   685 QPET----KRMVE------HYTAYLSDNTRLIANPGLKFSVRNE--VMATSHVTDEWMTQMEMSS 737

  Fly   862 RNEFKQRFGVTVAFLATHSGLTRWHEFHSNAAEESGVGETFSQNNTRAIDEIWYKRAVDQHFVRE 926
            .|.:     :...::||.:|:.|   .:..:..:.....|..|         ||..||....:..
Mouse   738 LNTY-----IVRRYIATPNGVLR---IYPGSLMDKAFDPTRRQ---------WYLHAVANPGLIS 785

  Fly   927 ESFVYSVPFDAGESNSEILVTASHAVFHN----EGGKTAPAAVVGFQFQHSALYKLFHNITGNAC 987
            .:..|   .|.|  .:..:||.||.:..:    ..|.|  .||:|..|.....||:..::. ..|
Mouse   786 LTGPY---LDVG--GAGYVVTISHTIHSSSTQLSSGHT--VAVMGIDFTLRYFYKVLMDLL-PVC 842

  Fly   988 AVDDKD---CYILDNNGYVIISTRVHET 1012
            ..|..:   |:|:::.||::    .|.|
Mouse   843 NQDGGNKIRCFIMEDRGYLV----AHPT 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stj	NP_001246303.1	VWA_N	107..241	CDD:285584	28/136 (21%)
		vWA_VGCC_like	253..439	CDD:238740	50/212 (24%)
		Cache_1	524..619	CDD:280839	25/95 (26%)
Cachd1	NP_932154.1	VWA_N	103..218	CDD:285584	33/157 (21%)
		vWFA	227..422	CDD:294047	49/205 (24%)
		Cache_1	470..537	CDD:280839	21/75 (28%)
		Cache_1	786..867	CDD:280839	23/93 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1157..1176
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1187..1237
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2353
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810