DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stj and Cacna2d4

DIOPT Version :9

Sequence 1:	NP_001246303.1	Gene:	stj / 36526	FlyBaseID:	FBgn0261041	Length:	1271	Species:	Drosophila melanogaster
Sequence 2:	XP_036022112.1	Gene:	Cacna2d4 / 319734	MGIID:	2442632	Length:	1137	Species:	Mus musculus

Alignment Length:	1325	Identity:	428/1325 - (32%)
Similarity:	631/1325 - (47%)	Gaps:	301/1325 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 WSRLLAWWR--LCLGLLSVLVCLAPCVNLQ---PAENINYNLVHSWADKLGMELFHLGDFITRRK 62
            |:.|   |:  :.|.||.....| |.|..|   |.|.:..     |||..|..|::.   :||..
Mouse    51 WTSL---WKTPIILWLLLSDTSL-PTVRGQTTVPLETVKL-----WADTFGRNLYNT---VTRYS 103

  Fly    63 E---VQESFKDA----KVVSRNGASIVDSMAKEIEMMMDLKVSAVRRIMDTAENTALSHQNDMAD 120
            .   :|:.:|||    |:...:|..:|...::::|.|:..||.||..:::.||...|:|:.: |.
Mouse   104 GSLLLQKKYKDAEPSLKIKEVDGLELVKKFSEDMETMLRRKVEAVESLVEAAEEADLNHEFN-AS 167

  Fly   121 KMFSYYSA---KEMLEPGDPVPPIPTPAPDMDKDIGEPLIYVQPKVVVLEPRPEFHNTPVNFSVS 182
            .:|:||::   .|..:.|:.|            ::|...:        ||....|.|..||.|:|
Mouse   168 LVFNYYNSVLINEKDDKGNYV------------ELGAEFL--------LESDAHFSNLRVNVSMS 212

  Fly   183 SVHVPVNVFDRAPDVIKAIQWSENLDQIFRDNYKNDPTLSWQFFGSSTGFMRQFPASKWRKDV-P 246
            ||.:|.||:::.||::..:..||.|:.:|.:|::.||||:||:|||||||.|.:|..||..|. .
Mouse   213 SVQLPTNVYNKDPDILNGVYMSEALNPVFVENFQRDPTLTWQYFGSSTGFFRIYPGIKWMPDENG 277

  Fly   247 VDLYDCRLRSWYMEAATSPKDIVILMDGSGSMLGQRLDIAKHVVNTILDTLGTNDFVNIFTFDKE 311
            |..:|||.|.||::|||||||||||:|.||||.|.|:.||||.:.|||||||.||||||..::..
Mouse   278 VIAFDCRNRGWYIQAATSPKDIVILVDISGSMKGLRMAIAKHTITTILDTLGENDFVNIIAYNDY 342

  Fly   312 VSPVVPCFEDTLIQANLGNIRELKEGIELFRPKSIANYTAALTKAFELLEETKLSSRGAQCNQAI 376
            |..:.|||:..|:||:..|....|:.::....|.:...:.||.:|||:|::.:.|.:|:.|||||
Mouse   343 VHYIEPCFKGILVQADRDNREHFKQLVDELMVKGVGVVSQALIEAFEILKQFQESKQGSLCNQAI 407

  Fly   377 MIIGDGAPENNREVFELHNWRDPPYKPVRVFTYLIGKEVANWDDIRWMACENQGYYVHLSDTAEV 441
            |:|.|||.|:...|||.:||   |.:.|||||||||:||...|.::|:||.|:|||..:|..|:.
Mouse   408 MLITDGAVEDYEPVFETYNW---PDRKVRVFTYLIGREVTFADRMKWIACNNKGYYTQISTLADA 469

  Fly   442 REMVLNYIPVMARPLVLGRHDHPVIWSQVYADIEDTKLSDYLWDINQCEYQKADVLEYWQVHDRM 506
            :|.|:.|:.|::||:|: .|||.:||::.|.|                              .|:
Mouse   470 QESVMEYLHVLSRPMVI-NHDHDIIWTEAYMD------------------------------SRL 503

  Fly   507 LEPSEMHRRKYRRMKETWNQPVDSNVYQFMTTVSMPIYDRRENALINLTTDINPAAKINLQVTRI 571
            ...                   ::.....:|||:||::.::..                   ||.
Mouse   504 FTS-------------------EAQSLMLLTTVAMPVFSKKNE-------------------TRS 530

  Fly   572 ANI-LGVAGTDVPINEIKKLLSPFTLGVNGYAFIVTNNGYVLFHPDFRPIF-QGYIL--KPAYNS 632
            ..| |||.|:||.:.|:.||...:.|||:||||:.|||||:|.|||.||:: :|..|  ||.|||
Mouse   531 HGILLGVVGSDVTLRELMKLAPRYKLGVHGYAFLNTNNGYILSHPDLRPLYREGKKLRPKPNYNS 595

  Fly   633 VDMIEVELLDDDRPARDFNPVLMTIRDSIINQSTGSKWMLVKNHFDEMKRVARVKRQYYWTAIKK 697
            ||:.|||..|...          .:|.::||..|||..|.||...|:.|||..:...|::|.|..
Mouse   596 VDLSEVEWEDQAE----------ILRTAMINGETGSHSMDVKVPLDKGKRVLFLTNDYFFTDISD 650

  Fly   698 TPFTLVISYPEQYGVSHMDIRADQEIHRISIKGTNLRSVFSGKRWKIHP------DWLFCKHSNR 756
            |||:|.:.....:|            ..|.:..|   ||..|....:||      ||::|    .
Mouse   651 TPFSLGVVLTRGHG------------EYILLGNT---SVEEGLHDLLHPDLTLASDWIYC----I 696

  Fly   757 TFKTPEIELLYFLERMSEPGWRWPGSRSAMPPEHAAAMFSNNSSTGRYPSINEKESYYCDRQLMQ 821
            |...|:...|..||                    |...|    .||..|.:.      ||.:|::
Mouse   697 TDIDPDHRKLSQLE--------------------AVVRF----LTGVDPDLE------CDEELVR 731

  Fly   822 ALVFDARVTG-----WFSNNTSFNSKDDKGTSASSPIAVLMGLLPRNEFKQRFGVTVAFLATHSG 881
            .::|||.||.     |.:  .:.|..::     |.|                 ||.||||.|.:|
Mouse   732 EVLFDAVVTAPMEAYWTA--LALNISEE-----SEP-----------------GVDVAFLGTRAG 772

  Fly   882 LTRWHEFHSN----------AAEESGVGETFSQNNTRAIDEIWYKRAVDQHFVREESFVYSVPFD 936
            |.|...|..:          ..:|:.:   |:.::.    .:||::|.:|   ...|||:::.:.
Mouse   773 LLRRSLFVGSEKVSDRKFLTPEDEASI---FTMDHF----PLWYRQASEQ---PPGSFVFNLRWA 827

  Fly   937 AGESN--SEILVTASHAVFHNEGGKTAPAAVVGFQFQHSALYKLF-------HNITG---NACAV 989
            .|..:  ..:.|.||.||.....||||.||.||.|.|...|.:.|       :.:.|   .:|..
Mouse   828 EGPDSPGKPVAVRASTAVTVTVDGKTAIAAAVGIQMQADYLQRQFWAAMQQCNAVEGPCLKSCED 892

  Fly   990 DDKDCYILDNNGYVIISTRVHETGRFFGEVNGAIMKRLLEENVYRQVTVYDYQAVCFESKNDNNA 1054
            .|.||:::||||:|:||.|..|.||..||.:||:||:||...|:.:||:|||||:|....:.::|
Mouse   893 TDLDCFVIDNNGFVLISERPQEMGRLLGEADGALMKQLLSMGVFSRVTMYDYQAMCKPPDHHHSA 957

  Fly  1055 SSMLLSPLFHLLRVGKWLLHTALWYIVQLLQWAPGVSSHYADMYGDSNDTEPPPPEPHPDHHARN 1119
            :..|.|||...|.|.:||||..|.:   ||:|:         .:|...|              :.
Mouse   958 AESLFSPLSAFLMVARWLLHECLLF---LLEWS---------AWGSWQD--------------KG 996

  Fly  1120 GNGHGKKDDDHWLRYLTLHRTRLKPCDMKRDLY---TLFNEKDNVVYNMTAHACERPFVVLPIPF 1181
            ...|..|..|      .||     |||.:..::   |...|.:.::   ....|::.||:..||.
Mouse   997 SEAHKHKKQD------LLH-----PCDTEYPVFVHQTAIQEANGII---ECGGCQKTFVMQQIPR 1047

  Fly  1182 SNLILLVIDQLCPRDGSVVLTVNPQPIDYHLSVNDSLACYKQAREFNRMRPHSCISRHANESGIK 1246
            |||:|||.|:.|.......:......:.|    |.|:.|.:...:..|.||.||.:.|..|:. :
Mouse  1048 SNLLLLVTDRTCDCSAHSPILQEATEVKY----NASVKCDRMRSQKPRRRPGSCHAFHPEENA-Q 1107

  Fly  1247 LCGKACSVYANLGLLLLCHILSRWL 1271
            .||.|.....:..||||.  |..||
Mouse  1108 DCGGASDTLPSSPLLLLS--LGAWL 1130

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stj	NP_001246303.1	VWA_N	107..241	CDD:285584	47/136 (35%)
		vWA_VGCC_like	253..439	CDD:238740	94/185 (51%)
		Cache_1	524..619	CDD:280839	33/95 (35%)
Cacna2d4	XP_036022112.1	VWA_N	155..271	CDD:400621	47/136 (35%)
		vWA_VGCC_like	284..467	CDD:238740	94/185 (51%)
		HK_sensor	<491..544	CDD:365792	19/120 (16%)
		HK_sensor	546..659	CDD:365792	54/122 (44%)
		VGCC_alpha2	694..1110	CDD:400667	145/528 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832112
Domainoid	1	1.000	163	1.000	Domainoid score	I3947
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	577	1.000	Inparanoid score	I1031
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45864
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000496
OrthoInspector	1	1.000	-	-		mtm8846
orthoMCL	1	0.900	-	-		OOG6_103783
Panther	1	1.100	-	-	O	PTHR10166
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5109
SonicParanoid	1	1.000	-	-		X365
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.930