DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stj and Cacna2d4

DIOPT Version :9

Sequence 1:	NP_001246303.1	Gene:	stj / 36526	FlyBaseID:	FBgn0261041	Length:	1271	Species:	Drosophila melanogaster
Sequence 2:	NP_001178680.2	Gene:	Cacna2d4 / 312668	RGDID:	1562038	Length:	1144	Species:	Rattus norvegicus

Alignment Length:	1324	Identity:	421/1324 - (31%)
Similarity:	631/1324 - (47%)	Gaps:	292/1324 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AWSRL----LAWWRLCLGLLSVLVCLAPCVNLQPAENINYNLVHSWADKLGMELFHLGDFITRRK 62
            ||:.|    :..|.|   ||...:..|......|.|.:..     ||:..|.:|:   ..:||..
  Rat    50 AWTFLRKMPIVLWLL---LLDTSLPTARSQATIPLETVKL-----WAETFGRDLY---STVTRYS 103

  Fly    63 E---VQESFKDA----KVVSRNGASIVDSMAKEIEMMMDLKVSAVRRIMDTAENTALSHQNDMAD 120
            .   :|:.:|||    |:...:|..:|...::::|.|:..||.||..:::.||...|:|:.: |.
  Rat   104 GSLLLQKKYKDAEPSLKIKEVDGLELVKKFSEDMETMLRRKVEAVESLVEAAEEADLNHEFN-AS 167

  Fly   121 KMFSYYSA---KEMLEPGDPVPPIPTPAPDMDKDIGEPLIYVQPKVVVLEPRPEFHNTPVNFSVS 182
            .:|:||::   .|..:.|:.|            ::|...:        ||....|:|..||.|:|
  Rat   168 LVFNYYNSVLINEKDDKGNYV------------ELGAEFL--------LESDAHFNNLRVNVSMS 212

  Fly   183 SVHVPVNVFDRAPDVIKAIQWSENLDQIFRDNYKNDPTLSWQFFGSSTGFMRQFPASKWRKDV-P 246
            ||.:|.||:::.||::..:..||.|:.:|.:|::.||||:||:|||||||.|.:|..||..|. .
  Rat   213 SVQLPTNVYNKDPDILNGVYMSEALNPVFVENFQRDPTLTWQYFGSSTGFFRIYPGIKWTPDENG 277

  Fly   247 VDLYDCRLRSWYMEAATSPKDIVILMDGSGSMLGQRLDIAKHVVNTILDTLGTNDFVNIFTFDKE 311
            |..:|||.|.||::|||||||||||:|.||||.|.|:.||||.|.|||||||.||||||..::..
  Rat   278 VIAFDCRNRGWYIQAATSPKDIVILVDMSGSMKGLRMAIAKHTVTTILDTLGENDFVNIIAYNDY 342

  Fly   312 VSPVVPCFEDTLIQANLGNIRELKEGIELFRPKSIANYTAALTKAFELLEETKLSSRGAQCNQAI 376
            |..:.|||:..|:||:..|....|:.::....|.:...:.||.:||::|::.:.|.:|:.|||||
  Rat   343 VHYIEPCFKGILVQADRDNREHFKQLVDELMVKGVGIVSQALIEAFQILKQFQESRQGSLCNQAI 407

  Fly   377 MIIGDGAPENNREVFELHNWRDPPYKPVRVFTYLIGKEVANWDDIRWMACENQGYYVHLSDTAEV 441
            |::.|||.|:...|||.:||   |.:.|||||||||:||...|.::|:||.|:|||..:|..|:.
  Rat   408 MLVTDGAVEDYEPVFETYNW---PDRKVRVFTYLIGREVTFADRMKWIACNNKGYYTQISTLADA 469

  Fly   442 REMVLNYIPVMARPLVLGRHDHPVIWSQVYADIEDTKLSDYLWDINQCEYQKADVLEYWQVHDRM 506
            :|.|:.|:.|::||:|: .|||.:||::.|.|                              .|:
  Rat   470 QENVMEYLHVLSRPMVI-NHDHDIIWTEAYMD------------------------------SRL 503

  Fly   507 LEPSEMHRRKYRRMKETWNQPVDSNVYQFMTTVSMPIYDRRENALINLTTDINPAAKINLQVTRI 571
            |..                   ::.....:|||:||::.::..                   ||.
  Rat   504 LTS-------------------EAQSLMLLTTVAMPVFSKKNE-------------------TRS 530

  Fly   572 ANI-LGVAGTDVPINEIKKLLSPFTLGVNGYAFIVTNNGYVLFHPDFRPIF-QGYILKPA--YNS 632
            ..| |||.|:||.:.|:.||...:.|||:||||:.|||||:|.|||.||:: :|..|||.  |||
  Rat   531 HGILLGVVGSDVTLRELMKLAPRYKLGVHGYAFLNTNNGYILSHPDLRPLYREGKKLKPKPNYNS 595

  Fly   633 VDMIEVELLDDDRPARDFNPVLMTIRDSIINQSTGSKWMLVKNHFDEMKRVARVKRQYYWTAIKK 697
            ||:.|||..|...          .:|.::||..|||..|.||...|:.|||..:...|::|.|..
  Rat   596 VDLSEVEWEDQAE----------ILRTAMINGETGSHSMDVKVPLDKGKRVLFLTNDYFFTDISD 650

  Fly   698 TPFTLVISYPEQYGVSHMDIRADQEIHRISIKGTNLRSVFSGKRWKIHP------DWLFCKHSNR 756
            |||:|.:.....:|            ..|.:..|   ||..|....:||      ||::|    .
  Rat   651 TPFSLGVVLTRGHG------------EYILLGNT---SVEEGLHDLLHPDLTLASDWIYC----I 696

  Fly   757 TFKTPEIELLYFLERMSEPGWRWPGSRSAMPPEHAAAMFSNNSSTGRYPSINEKESYYCDRQLMQ 821
            |...|:...|..||                    |...|    .||..|.:.      ||.:|::
  Rat   697 TDIDPDHRKLSQLE--------------------AVVRF----LTGVDPDLE------CDEELVR 731

  Fly   822 ALVFDARVTG-----WFSNNTSFNSKDDKGTSASSPIAVLMGLLPRNEFKQRFGVTVAFLATHSG 881
            .::|||.||.     |.:  .:.|..::     |.|                 ||.||||.|.:|
  Rat   732 EVLFDAVVTAPMEAYWTA--LALNISEE-----SEP-----------------GVEVAFLGTRAG 772

  Fly   882 LTRWHEFHSN----------AAEESGVGETFSQNNTRAIDEIWYKRAVDQHFVREESFVYSVPFD 936
            |.|...|..:          ..:|:.:   |:.::.    .:||::|.:|   ...|||:::.:.
  Rat   773 LLRRSLFVGSEKVSDRKFLTPEDEASI---FTMDHF----PLWYRQASEQ---PPGSFVFNLRWA 827

  Fly   937 AGESN--SEILVTASHAVFHNEGGKTAPAAVVGFQFQHSALYKLF-------HNITG---NACAV 989
            .|..:  ..:.|.||.|:.....||||.||.||.|.|...|.:.|       :.:.|   ..|..
  Rat   828 EGPDSPGKPVAVRASTAITVTVDGKTAIAAAVGIQMQADYLQRQFWAAMQQCNTVEGPCPKRCQD 892

  Fly   990 DDKDCYILDNNGYVIISTRVHETGRFFGEVNGAIMKRLLEENVYRQVTVYDYQAVCFESKNDNNA 1054
            .|.||:::||||:::||.|..|.||..||.:||:|.:||...|:.:||:|||||:|....:.::|
  Rat   893 TDLDCFVIDNNGFILISERPQEIGRLLGEADGALMTQLLSMGVFSRVTMYDYQAMCKPPDHHHSA 957

  Fly  1055 SSMLLSPLFHLLRVGKWLLHTALWYIVQLLQWAPGVSSHYADMYGDSNDTEPPPPEPHPDHHARN 1119
            :..|:|||...|.|.|||||..|.::.:...|     ..:.|...::...         .||:..
  Rat   958 AESLISPLSAFLTVAKWLLHECLLFLFEWSAW-----GSWQDKGSEAKAV---------FHHSHK 1008

  Fly  1120 GNGHGKKDDDHWLRYLTLHRTRLKPCDMKRDLY---TLFNEKDNVVYNMTAHACERPFVVLPIPF 1181
               |.|:|        .||     |||.:..::   |...|.:.::   ....|::.||:..||.
  Rat  1009 ---HKKQD--------LLH-----PCDTEYPVFVHQTAIREANGII---ECGGCQKTFVMQQIPS 1054

  Fly  1182 SNLILLVIDQLCPRDGSVVLTVNPQPIDYHLSVNDSLACYKQAREFNRMRPHSCISRHANESGIK 1246
            |||:|||.|:.|.......:......:.|    |.|:.|.:...:..|.||.||.:.|..|:. :
  Rat  1055 SNLLLLVTDRTCDCSAYSPILQEATEVKY----NASVKCNRMRSQKPRRRPGSCHAFHPEENA-Q 1114

  Fly  1247 LCGKACSVYANLGLLLLCHILSRW 1270
            .||.|.....:..||||.  |..|
  Rat  1115 DCGGASDTLPSSPLLLLA--LWAW 1136

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stj	NP_001246303.1	VWA_N	107..241	CDD:285584	47/136 (35%)
		vWA_VGCC_like	253..439	CDD:238740	93/185 (50%)
		Cache_1	524..619	CDD:280839	33/95 (35%)
Cacna2d4	NP_001178680.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335779
Domainoid	1	1.000	162	1.000	Domainoid score	I3898
eggNOG	1	0.900	-	-		E1_KOG2353
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	578	1.000	Inparanoid score	I996
OMA	1	1.010	-	-		QHG45864
OrthoDB	1	1.010	-	-		D110668at33208
OrthoFinder	1	1.000	-	-		FOG0000496
OrthoInspector	1	1.000	-	-		mtm9092
orthoMCL	1	0.900	-	-		OOG6_103783
Panther	1	1.100	-	-	O	PTHR10166
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X365
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770