DRSC/TRiP Functional Genomics Resources

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Protein Alignment stj and Cacna2d3

DIOPT Version :9

Sequence 1:NP_001246303.1 Gene:stj / 36526 FlyBaseID:FBgn0261041 Length:1271 Species:Drosophila melanogaster
Sequence 2:XP_017455566.2 Gene:Cacna2d3 / 306243 RGDID:631361 Length:1091 Species:Rattus norvegicus


Alignment Length:1294 Identity:392/1294 - (30%)
Similarity:609/1294 - (47%) Gaps:309/1294 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 ENINYNLVHSWADKLGMELFHL-----GDFITRRKEVQESFKDAKVVSRNGASIVDSMAKEIEMM 92
            :.|..::|..||...|.|:..:     |..:.::| .:|..||..:...:|..:|..:||.:|.|
  Rat    35 QQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKK-YKEYEKDVAIEEIDGLQLVKKLAKNMEEM 98

  Fly    93 MDLKVSAVRRIMDTAENTALSHQNDMADKMFSYYSAKEMLEPGDPVPPIPTPAPDMDKD-----I 152
            ...|..||||:::.||...|.|:.| ||..:.|::|..:.|              .|||     :
  Rat    99 FHKKSEAVRRLVEAAEEAHLKHEFD-ADLQYEYFNAVLINE--------------RDKDGNFLEL 148

  Fly   153 GEPLIYVQPKVVVLEPRPEFHNTPVNFSVSSVHVPVNVFDRAPDVIKAIQWSENLDQIFRDNYKN 217
            |        |..:|.|...|:|.|||.|:|.|.||.|::::.|.::..:.|||:|:::|.||:..
  Rat   149 G--------KEFILAPNDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDR 205

  Fly   218 DPTLSWQFFGSSTGFMRQFPASKWRKDV-PVDLYDCRLRSWYMEAATSPKDIVILMDGSGSMLGQ 281
            ||:|.||:|||:.||.||:|..||..|. .|..:|||.|.||::|||||||:|||:|.||||.|.
  Rat   206 DPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGL 270

  Fly   282 RLDIAKHVVNTILDTLGTNDFVNIFTFDKEVSPVVPCFEDTLIQANLGNIRELKEGIELFRPKSI 346
            ||.|||..|::||||||.:||.||.|:::|:..|.||...||:||:..|....:|.::....|.|
  Rat   271 RLTIAKQTVSSILDTLGDDDFFNIITYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGI 335

  Fly   347 ANYTAALTKAFELLEETKLSSRGAQCNQAIMIIGDGAPENNREVFELHNWRDPPYKPVRVFTYLI 411
            .....||.:||.:|.:...:.:|:.|:||||:|.|||.:....:|..:||   |.:.||:|||||
  Rat   336 GMLDIALNEAFNVLSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNW---PERKVRIFTYLI 397

  Fly   412 GKEVANWDDIRWMACENQGYYVHLSDTAEVREMVLNYIPVMARPLVLGRHDHPVIWSQVYADI-- 474
            |:|.|..|:::||||.|:|::..:|..|:|:|.|:.|:.|::||.|:.: :|.|:|::.|.|.  
  Rat   398 GREAAFADNLKWMACANKGFFTQISTLADVQENVMEYLHVLSRPKVIDQ-EHDVVWTEAYIDSTL 461

  Fly   475 -EDTKLSDYLWDINQCEYQKADVLEYWQVHDRMLEPSEMHRRKYRRMKETWNQPVDSNVYQFMTT 538
             :..||:|                      |:.|                          ..|||
  Rat   462 PQAQKLAD----------------------DQGL--------------------------VLMTT 478

  Fly   539 VSMPIYDRRENALINLTTDINPAAKINLQVTRIANI-LGVAGTDVPINEIKKLLSPFTLGVNGYA 602
            |:||::.::..                   ||...| |||.|||||:.|:.|.:..:.||::|||
  Rat   479 VAMPVFSKQNE-------------------TRSKGILLGVVGTDVPVKELLKTIPKYKLGIHGYA 524

  Fly   603 FIVTNNGYVLFHPDFRPIFQ--GYILKPAYNSVDMIEVELLDDDRPARDFNPVLMTIRDSIINQS 665
            |.:|||||:|.||:.||:::  ....||.|:|||:.|||..|.|.          .:|::::|:.
  Rat   525 FAITNNGYILTHPELRPLYEEGKKRRKPNYSSVDLSEVEWEDRDD----------VLRNAMVNRK 579

  Fly   666 TGSKWMLVKNHFDEMKRVARVKRQYYWTAIKKTPFTLVISYPEQYGVSHM--DIRADQEIHRISI 728
            ||...|.||...|:.|||..:...||:|.||..||:|.::....:|....  ::..::.:|.:. 
  Rat   580 TGKFSMEVKKTVDKGKRVLVMTNDYYYTDIKGAPFSLGVALSRGHGKYFFRGNVTIEEGLHDLE- 643

  Fly   729 KGTNLRSVFSGKRWKIHPD------WLFCKHSNRTFKTPEIELLYFLERMSEPGWRWPGSRSAMP 787
                            |||      |.:|                               .:.:.
  Rat   644 ----------------HPDVSLADEWSYC-------------------------------NTDLH 661

  Fly   788 PEH-------AAAMFSNNSSTGRYPSINEKESYYCDRQLMQALVFDARVTG-----WFSNNTSFN 840
            |||       |..::..    |:.|.:.      ||::|:|.::|||.|:.     |.|...:.:
  Rat   662 PEHRHLSQLEAIKLYLK----GKEPLLQ------CDKELIQEVLFDAVVSAPIEAYWTSLALNKS 716

  Fly   841 SKDDKGTSASSPIAVLMGLLPRNEFKQRFGVTVAFLATHSGLTRWHEFHSNAAEESGVGETFSQN 905
            ...||                        ||.||||.|.:||:|.:.|       .|..:..:|:
  Rat   717 ENSDK------------------------GVEVAFLGTRTGLSRINLF-------VGAEQLTNQD 750

  Fly   906 NTRAIDE----------IWYKRAVDQHFVREESFVYSVPFDAGESNSEILVTASHAVFHNEGGKT 960
            ..:|.|:          :||:||.:|   ...|||||:||..|..|...:||||.::...:..|:
  Rat   751 FLKARDKENIFNADHFPLWYRRAAEQ---IPGSFVYSIPFSTGTVNKSNVVTASTSIQLLDERKS 812

  Fly   961 APAAVVGFQFQHSALYKLFHNITGNACAVDDK----------DCYILDNNGYVIISTRVHETGRF 1015
            ...|.||.|.:.....:.|...:....::|.|          :||::||||::::|....:||.|
  Rat   813 PVVAAVGIQMKLEFFQRKFWTASRQCASLDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTGDF 877

  Fly  1016 FGEVNGAIMKRLLEENVYRQVTVYDYQAVCFESKNDNNASSMLLSPLFHLLRVGKWLLHTALWYI 1080
            ||||.||:|.:||....::::|:|||||:|..:|..::::..||.|....|...||::...:.::
  Rat   878 FGEVEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDSAHGLLDPYKAFLSAAKWIVTELVLFL 942

  Fly  1081 VQ--LLQWAPGVSSHYADMYGDSNDTEPPPPEPHPDHHARNGNGHGKKDDDHWLRYLTLHRTRLK 1143
            |:  |..|                                            |...:|....:||
  Rat   943 VEFNLCSW--------------------------------------------WHSDMTAKAQKLK 963

  Fly  1144 ----PCDMKRDLYTLFNEKDNVVYNMTAHACERPFVVLPIPFSNLILLVIDQLCPRDGSVVLTVN 1204
                |||.:...:...........|:....|.:.||:..||.|||.::|:|..|..:....:|:.
  Rat   964 QTLEPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMA 1028

  Fly  1205 PQPIDYHLSVNDSLACYKQAREFNRMRPHSCISRHANESGIKLCGKACSVYANLGLLLL 1263
            |..|.|    |:||.|.:...:..|.||.||...|..|:. :.||.|.|:.|.:.||||
  Rat  1029 PIEIRY----NESLKCERLKAQKIRRRPESCHGFHPEENA-RECGGASSLQAQVALLLL 1082

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
stjNP_001246303.1 VWA_N 107..241 CDD:285584 49/138 (36%)
vWA_VGCC_like 253..439 CDD:238740 86/185 (46%)
Cache_1 524..619 CDD:280839 33/95 (35%)
Cacna2d3XP_017455566.2 VWA_N 113..229 CDD:400621 49/138 (36%)
vWA_VGCC_like 242..425 CDD:238740 86/185 (46%)
HK_sensor <446..506 CDD:365792 26/127 (20%)
PDC2_MCP_like 508..622 CDD:350337 48/123 (39%)
VGCC_alpha2 655..1068 CDD:400667 130/536 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166335777
Domainoid 1 1.000 162 1.000 Domainoid score I3898
eggNOG 1 0.900 - - E1_KOG2353
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H74929
Inparanoid 1 1.050 578 1.000 Inparanoid score I996
OMA 1 1.010 - - QHG45864
OrthoDB 1 1.010 - - D110668at33208
OrthoFinder 1 1.000 - - FOG0000496
OrthoInspector 1 1.000 - - mtm9092
orthoMCL 1 0.900 - - OOG6_103783
Panther 1 1.100 - - O PTHR10166
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X365
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1514.770

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