Protein Alignment stj and Cacna2d2

DIOPT Version :10

• Sequence 1: NP_001246303.1
• Gene: stj / 36526
• FlyBaseID: FBgn0261041
• Length: 1271
• Species: Drosophila melanogaster
• Sequence 2: NP_783182.2
• Gene: Cacna2d2 / 300992
• RGDID: 631360
• Length: 1157
• Species: Rattus norvegicus
• Alignment Length: 1334
• Identity: 342/1334 - (25%)
• Similarity: 558/1334 - (41%)
• Gaps: 326/1334 - (24%)

  Fly    16 LLSVLVCLAPCVNLQPAENINYNLVHS---WADKLGMELFHLGDFITRRKEVQESFKDAK----V 73
            ||...:.|.|.:....|...::...|:   ||.:|..|:..:.......::::|.:||.:    |
  Rat    46 LLLPPLLLLPLLTAPGASAYSFPQQHTMQHWARRLEQEIDGVMRIFGGVQQLREIYKDNRNLFDV 110

  Fly    74 VSRNGASIVDSMAKEIEMMMDLKVSAVRRIMDTAENTALSH--QNDMADKMFSYYSAKEMLEPGD 136
            .......:|:.:|.:||.::|.||.|::|:.|.|||...:|  |:::.::...||.||...|..|
  Rat   111 QENEPQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIMYYDAKADAELDD 175

  Fly   137 PVPPIPTPAPDMD---KDIGEPLIYVQPKVVVLEPRPEFHNTPVNFSVSSVHVPVNVFDRAPDVI 198
            |      .:.||:   |.....|.:::        .|.|.| .||:|.::|.:|.:::..:..::
  Rat   176 P------ESEDMERGSKTSALRLDFIE--------EPNFKN-KVNYSYTAVQIPTDIYKGSTVIL 225

  Fly   199 KAIQWSENLDQIFRDNYKNDPTLSWQFFGSSTGFMRQFPASKWRKDVPVDLYDCRLRSWYMEAAT 263
            ..:.|:|.|:.:|.:|.:.||||.||.|||:||..|.:||:.||....:||||.|.|.||::.|:
  Rat   226 NELNWTEALENVFIENRRQDPTLLWQVFGSATGVTRYYPATPWRAPKKIDLYDVRRRPWYIQGAS 290

  Fly   264 SPKDIVILMDGSGSMLGQRLDIAKHVVNTILDTLGTNDFVNIFTFDKEVSPVVPCFEDTLIQANL 328
            ||||:||::|.|||:.|..|.:.|..|..:||||..:|:||:.:|:::..| |.||.. |:|||:
  Rat   291 SPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASFNEKAQP-VSCFTH-LVQANV 353

  Fly   329 GNIRELKEGIELFRPKSIANYTAALTKAFELLEETKLSSRGAQCNQAIMIIGDGAPENNREVFEL 393
            .|.:..||.::....|....|.|....||:.|:.:.::.  |.||:.||:..||..:..::|||.
  Rat   354 RNKKVFKEAVQGMVAKGTTGYKAGFEYAFDQLQNSNITR--ANCNKMIMMFTDGGEDRVQDVFEK 416

  Fly   394 HNWRDPPYKPVRVFTYLIGKEVANWD--DIRWMACENQGYYVHLSDTAEVREMVLNYIPVMARPL 456
            :||   |.:.|||||:.:|:.  |:|  .::||||.|:|||..:.....:|.....|:.|:.||:
  Rat   417 YNW---PNRTVRVFTFSVGQH--NYDVTPLQWMACTNKGYYFEIPSIGAIRINTQEYLDVLGRPM 476

  Fly   457 VL-GRHDHPVIWSQVYADIEDTKLSDYLWDINQCEYQKADVLEYWQVHDRMLEPSEMHRRKYRRM 520
            || |:....|.|:.||.|.....|
  Rat   477 VLAGKDAKQVQWTNVYEDALGLGL----------------------------------------- 500

  Fly   521 KETWNQPVDSNVYQFMTTVSMPIYDRRENALINLTTDINPAAKINLQVTRIANILGVAGTDVPIN 585
                           :.|.::|::        |||.| .|..|.| |:     ||||.|.||.:|
  Rat   501 ---------------VVTGTLPVF--------NLTQD-GPGEKKN-QL-----ILGVMGIDVALN 535

  Fly   586 EIKKLLSPFTLGVNGYAFIVTNNGYVLFHPDFRPIFQGYILKPAYNSVDMIEVELLDDDRPARDF 650
            :||:|...:|||.|||.|.:..|||||.||:.:|....: .:|.  ::|.::.||.|:::.
  Rat   536 DIKRLTPNYTLGANGYVFAIDLNGYVLLHPNLKPQTTNF-REPV--TLDFLDAELEDENKE---- 593

  Fly   651 NPVLMTIRDSIINQSTGSKWM--LVKNHFDEMKRVARVKRQYYWTAIKKTPFTLVISYPEQYGVS 713
                 .||.|:|:...|.|.:  |||: .|| :.:..|.|.|.|..|:.|.::|.:..| .|...
  Rat   594 -----EIRRSMIDGDKGHKQIRTLVKS-LDE-RYIDEVIRNYTWVPIRSTNYSLGLVLP-PYSTY 650

  Fly   714 HMDIRADQEIHRISIKGTNLRS--------------VFSGKRWKIHPDWLFCKHSNRTFKTPEIE 764
            ::......:|.::.:..:.|:.              ||...|       .:||..|.:....|.
  Rat   651 YLQANLSDQILQVKLPISKLKDFEFLLPSSFESEGHVFIAPR-------EYCKDLNASDNNTEF- 707

  Fly   765 LLYFLERMSEPGWRWPGSRSAMPPEHAAAMFSNNSSTGRYPSINEKESYYCDRQLMQALVFDARV 829
            |..|:|.|.:           :.|                      :|..|:..|:..|:.|..:
  Rat   708 LKNFIELMEK-----------VTP----------------------DSKQCNNFLLHNLILDTGI 739

  Fly   830 TGWFSNNTSFNSKDDKGTSASSPIAVLMGLLPRNEFKQRFGVTVAFLATHSGLTRWHEFHSNAAE 894
            |                       ..|:..:.|::....:.:...|.||..|:||  .|.:.|||
  Rat   740 T-----------------------QQLVERVWRDQDLNTYSLLAVFAATDGGITR--VFPNKAAE 779

  Fly   895 ESGVGETFSQNNTRAIDEIWYKRAVDQHFVREESFVYSVPFDAG------ESNSEILVTASHAVF 953
            :       ...|....:..:|:|::|     ...:::..|....      ..|..:.|..|.||.
  Rat   780 D-------WTENPEPFNASFYRRSLD-----NRGYIFKPPHQDSLLRPLELENDTVGVLVSTAVE 832

  Fly   954 HNEGGKTAPAAVVGFQFQHSALYKLFHNITGNA-------------------CAVDDKD--CYIL 997
            .:.|.:|...||||.:....|..:.|..:..|.                   |.|:::|  |.::
  Rat   833 LSLGRRTLRPAVVGVKLDLEAWAEKFKVLASNRTHQDQPQKQCGPSSHCEMDCEVNNEDLLCVLI 897

  Fly   998 DNNGYVIISTRVH---ETGRFFGEVNGAIMKRLLEENVYRQVTVYDYQAVCFESKNDNNASS--- 1056
            |:.|::::|.:.|   :.||||.||:..:|..|...:.|.:...|||||.|......|..::
  Rat   898 DDGGFLVLSNQNHQWDQVGRFFSEVDANLMLALYNNSFYTRKESYDYQAACAPQPPGNLGAAPRG 962

  Fly  1057 MLLSPLFHLLRVGKWLLHTALWYIVQLLQWAPGVSSHYADMYGDSNDTEPPPPEPHPDHHARNGN 1121
            :.:..:...|.:. |....|.|.:.|.|.        |..:|......:|...|..|:
  Rat   963 VFVPTIADFLNLA-WWTSAAAWSLFQQLL--------YGLIYHSWFQADPAEAEGSPE------- 1011

  Fly  1122 GHGKKDDDHWLRYLTLHRTRLKPCDMKRDLYTLFNEKDNVVYN--MTAHACERPFVVLPIPFSNL 1184
                              ||...|.||:..|  :....|..||  :....|.|.|....:..:||
  Rat  1012 ------------------TRESSCVMKQTQY--YFGSVNASYNAIIDCGNCSRLFHAQRLTNTNL 1056

  Fly  1185 ILLVIDQ----------------LCPRDGSVVLTVNPQPIDYHLSVNDSLACYKQAREFNRMRPH 1233
            :.:|.::                .||.||       |:            .|....|...|..||
  Rat  1057 LFVVAEKPLCSQCEVGRLLQKETHCPADG-------PE------------QCELVQRPRYRRGPH 1102

  Fly  1234 SCISRHANESGIKLCGKACSVYANLGLLLLCHIL 1267
            .|...:|.|. ...||:..|...:||:|:...:|
  Rat  1103 ICFDYNATED-TSDCGRGASFPPSLGVLVSLQLL 1135

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
stj	NP_001246303.1	VWA_N	107..241	CDD:462464	43/138 (31%)
		vWA_VGCC_like	253..439	CDD:238740	73/187 (39%)
		dCache_1	<528..624	CDD:460673	36/95 (38%)
		PDC2_MCP_like	586..708	CDD:350337	41/123 (33%)
		VGCC_alpha2	870..>1084	CDD:462488	58/246 (24%)
Cacna2d2	NP_783182.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..37
		VWA_N	144..268	CDD:462464	43/138 (31%)
		vWA_VGCC_like	280..459	CDD:238740	73/187 (39%)
		MIDAS-like motif	300..304		2/3 (67%)
		HK_sensor	536..645	CDD:365792	41/122 (34%)
		VGCC_alpha2	672..1117	CDD:462488	112/578 (19%)