DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stj and Cacna2d2

DIOPT Version :9

Sequence 1:	NP_001246303.1	Gene:	stj / 36526	FlyBaseID:	FBgn0261041	Length:	1271	Species:	Drosophila melanogaster
Sequence 2:	NP_783182.1	Gene:	Cacna2d2 / 300992	RGDID:	631360	Length:	1157	Species:	Rattus norvegicus

Alignment Length:	1334	Identity:	342/1334 - (25%)
Similarity:	558/1334 - (41%)	Gaps:	326/1334 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LLSVLVCLAPCVNLQPAENINYNLVHS---WADKLGMELFHLGDFITRRKEVQESFKDAK----V 73
            ||...:.|.|.:....|...::...|:   ||.:|..|:..:.......::::|.:||.:    |
  Rat    46 LLLPPLLLLPLLTAPGASAYSFPQQHTMQHWARRLEQEIDGVMRIFGGVQQLREIYKDNRNLFDV 110

  Fly    74 VSRNGASIVDSMAKEIEMMMDLKVSAVRRIMDTAENTALSH--QNDMADKMFSYYSAKEMLEPGD 136
            .......:|:.:|.:||.::|.||.|::|:.|.|||...:|  |:::.::...||.||...|..|
  Rat   111 QENEPQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIMYYDAKADAELDD 175

  Fly   137 PVPPIPTPAPDMD---KDIGEPLIYVQPKVVVLEPRPEFHNTPVNFSVSSVHVPVNVFDRAPDVI 198
            |      .:.||:   |.....|.:::        .|.|.| .||:|.::|.:|.:::..:..::
  Rat   176 P------ESEDMERGSKTSALRLDFIE--------EPNFKN-KVNYSYTAVQIPTDIYKGSTVIL 225

  Fly   199 KAIQWSENLDQIFRDNYKNDPTLSWQFFGSSTGFMRQFPASKWRKDVPVDLYDCRLRSWYMEAAT 263
            ..:.|:|.|:.:|.:|.:.||||.||.|||:||..|.:||:.||....:||||.|.|.||::.|:
  Rat   226 NELNWTEALENVFIENRRQDPTLLWQVFGSATGVTRYYPATPWRAPKKIDLYDVRRRPWYIQGAS 290

  Fly   264 SPKDIVILMDGSGSMLGQRLDIAKHVVNTILDTLGTNDFVNIFTFDKEVSPVVPCFEDTLIQANL 328
            ||||:||::|.|||:.|..|.:.|..|..:||||..:|:||:.:|:::..| |.||.. |:|||:
  Rat   291 SPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASFNEKAQP-VSCFTH-LVQANV 353

  Fly   329 GNIRELKEGIELFRPKSIANYTAALTKAFELLEETKLSSRGAQCNQAIMIIGDGAPENNREVFEL 393
            .|.:..||.::....|....|.|....||:.|:.:.::.  |.||:.||:..||..:..::|||.
  Rat   354 RNKKVFKEAVQGMVAKGTTGYKAGFEYAFDQLQNSNITR--ANCNKMIMMFTDGGEDRVQDVFEK 416

  Fly   394 HNWRDPPYKPVRVFTYLIGKEVANWD--DIRWMACENQGYYVHLSDTAEVREMVLNYIPVMARPL 456
            :||   |.:.|||||:.:|:.  |:|  .::||||.|:|||..:.....:|.....|:.|:.||:
  Rat   417 YNW---PNRTVRVFTFSVGQH--NYDVTPLQWMACTNKGYYFEIPSIGAIRINTQEYLDVLGRPM 476

  Fly   457 VL-GRHDHPVIWSQVYADIEDTKLSDYLWDINQCEYQKADVLEYWQVHDRMLEPSEMHRRKYRRM 520
            || |:....|.|:.||.|.....|
  Rat   477 VLAGKDAKQVQWTNVYEDALGLGL----------------------------------------- 500

  Fly   521 KETWNQPVDSNVYQFMTTVSMPIYDRRENALINLTTDINPAAKINLQVTRIANILGVAGTDVPIN 585
                           :.|.::|::        |||.| .|..|.| |:     ||||.|.||.:|
  Rat   501 ---------------VVTGTLPVF--------NLTQD-GPGDKKN-QL-----ILGVMGIDVALN 535

  Fly   586 EIKKLLSPFTLGVNGYAFIVTNNGYVLFHPDFRPIFQGYILKPAYNSVDMIEVELLDDDRPARDF 650
            :||:|...:|||.|||.|.:..|||||.||:.:|....: .:|.  ::|.::.||.|:::.
  Rat   536 DIKRLTPNYTLGANGYVFAIDLNGYVLLHPNLKPQITNF-REPV--TLDFLDAELEDENKE---- 593

  Fly   651 NPVLMTIRDSIINQSTGSKWM--LVKNHFDEMKRVARVKRQYYWTAIKKTPFTLVISYPEQYGVS 713
                 .||.|:|:...|.|.:  |||: .|| :.:..|.|.|.|..|:.|.::|.:..| .|...
  Rat   594 -----EIRRSMIDGDKGHKQIRTLVKS-LDE-RYIDEVIRNYTWVPIRSTNYSLGLVLP-PYSTY 650

  Fly   714 HMDIRADQEIHRISIKGTNLRS--------------VFSGKRWKIHPDWLFCKHSNRTFKTPEIE 764
            ::......:|.::.:..:.|:.              ||...|       .:||..|.:....|.
  Rat   651 YLQANLSDQILQVKLPISKLKDFEFLLPSSFESEGHVFIAPR-------EYCKDLNASDNNTEF- 707

  Fly   765 LLYFLERMSEPGWRWPGSRSAMPPEHAAAMFSNNSSTGRYPSINEKESYYCDRQLMQALVFDARV 829
            |..|:|.|.:           :.|                      :|..|:..|:..|:.|..:
  Rat   708 LKNFIELMEK-----------VTP----------------------DSKQCNNFLLHNLILDTGI 739

  Fly   830 TGWFSNNTSFNSKDDKGTSASSPIAVLMGLLPRNEFKQRFGVTVAFLATHSGLTRWHEFHSNAAE 894
            |                       ..|:..:.|::....:.:...|.||..|:||  .|.:.|||
  Rat   740 T-----------------------QQLVERVWRDQDLNTYSLLAVFAATDGGITR--VFPNKAAE 779

  Fly   895 ESGVGETFSQNNTRAIDEIWYKRAVDQHFVREESFVYSVPFDAG------ESNSEILVTASHAVF 953
            :       ...|....:..:|:|::|     ...:::..|....      ..|..:.|..|.||.
  Rat   780 D-------WTENPEPFNASFYRRSLD-----NRGYIFKPPHQDSLLRPLELENDTVGVLVSTAVE 832

  Fly   954 HNEGGKTAPAAVVGFQFQHSALYKLFHNITGNA-------------------CAVDDKD--CYIL 997
            .:.|.:|...||||.:....|..:.|..:..|.                   |.|:::|  |.::
  Rat   833 LSLGRRTLRPAVVGVKLDLEAWAEKFKVLASNRTHQDQPQKQCGPSSHCEMDCEVNNEDLLCVLI 897

  Fly   998 DNNGYVIISTRVH---ETGRFFGEVNGAIMKRLLEENVYRQVTVYDYQAVCFESKNDNNASS--- 1056
            |:.|::::|.:.|   :.||||.||:..:|..|...:.|.:...|||||.|......|..::
  Rat   898 DDGGFLVLSNQNHQWDQVGRFFSEVDANLMLALYNNSFYTRKESYDYQAACAPQPPGNLGAAPRG 962

  Fly  1057 MLLSPLFHLLRVGKWLLHTALWYIVQLLQWAPGVSSHYADMYGDSNDTEPPPPEPHPDHHARNGN 1121
            :.:..:...|.:. |....|.|.:.|.|.        |..:|......:|...|..|:
  Rat   963 VFVPTIADFLNLA-WWTSAAAWSLFQQLL--------YGLIYHSWFQADPAEAEGSPE------- 1011

  Fly  1122 GHGKKDDDHWLRYLTLHRTRLKPCDMKRDLYTLFNEKDNVVYN--MTAHACERPFVVLPIPFSNL 1184
                              ||...|.||:..|  :....|..||  :....|.|.|....:..:||
  Rat  1012 ------------------TRESSCVMKQTQY--YFGSVNASYNAIIDCGNCSRLFHAQRLTNTNL 1056

  Fly  1185 ILLVIDQ----------------LCPRDGSVVLTVNPQPIDYHLSVNDSLACYKQAREFNRMRPH 1233
            :.:|.::                .||.||       |:            .|....|...|..||
  Rat  1057 LFVVAEKPLCSQCEVGRLLQKETHCPADG-------PE------------QCELVQRPRYRTGPH 1102

  Fly  1234 SCISRHANESGIKLCGKACSVYANLGLLLLCHIL 1267
            .|...:|.|. ...||:..|...:||:|:...:|
  Rat  1103 ICFDYNATED-TSDCGRGASFPPSLGVLVSLQLL 1135

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stj	NP_001246303.1	VWA_N	107..241	CDD:285584	43/138 (31%)
		vWA_VGCC_like	253..439	CDD:238740	73/187 (39%)
		Cache_1	524..619	CDD:280839	35/94 (37%)
Cacna2d2	NP_783182.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37
		VWA_N	144..268	CDD:285584	43/138 (31%)
		vWA_VGCC_like	280..459	CDD:238740	73/187 (39%)
		MIDAS-like motif	300..304		2/3 (67%)
		Cache_1	488..576	CDD:280839	41/159 (26%)
		VGCC_alpha2	583..666	CDD:285647	24/94 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335780
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2353
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000496
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10166
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X365
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.840