DRSC/TRiP Functional Genomics Resources

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Protein Alignment stj and Cacna2d1

DIOPT Version :9

Sequence 1:NP_001246303.1 Gene:stj / 36526 FlyBaseID:FBgn0261041 Length:1271 Species:Drosophila melanogaster
Sequence 2:NP_037051.2 Gene:Cacna2d1 / 25399 RGDID:2247 Length:1091 Species:Rattus norvegicus


Alignment Length:1294 Identity:329/1294 - (25%)
Similarity:539/1294 - (41%) Gaps:306/1294 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    40 VHSWADKLGMELFHL---GDFITRRKEVQESFKDAKVVSRNGA-SIVDSMAKEIEMMMDLKVSAV 100
            :.||.||:..:|..|   ...:|:..::.|.::|...|..|.| .:|:..|::||.::..:..|:
  Rat    33 IKSWVDKMQEDLVTLAKTASGVTQLADIYEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKAL 97

  Fly   101 RRIMDTAENTALSHQ--NDMADKMFSYYSAKEMLEPGDPVPPIPTPAPDMDKDIGEPLIYVQPKV 163
            .|:...||....:||  .|.|.....||:||:.|:|           ...:.:.|...|    |.
  Rat    98 VRLAMEAEKVQAAHQWREDFASNEVVYYNAKDDLDP-----------ERNESESGSQRI----KP 147

  Fly   164 VVLEPRPEFHNTPVNFSVSSVHVPVNVFDRAPDVIKAIQWSENLDQIFRDNYKNDPTLSWQFFGS 228
            |.:|...  ....:::..::||:|.::::.:..|:..:.|:..||::|:.|...||||.||.|||
  Rat   148 VFIEDAN--FGRQISYQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKRNRDEDPTLLWQVFGS 210

  Fly   229 STGFMRQFPASKW----RKDVPVDLYDCRLRSWYMEAATSPKDIVILMDGSGSMLGQRLDIAKHV 289
            :||..|.:|||.|    |....:||||.|.|.||::.|.||||::||:|.|||:.|..|.:.:..
  Rat   211 ATGLARYYPASPWVDNSRTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTS 275

  Fly   290 VNTILDTLGTNDFVNIFTFDKEVSPVVPCFEDTLIQANLGNIRELKEGIELFRPKSIANYTAALT 354
            |:.:|:||..:||||:.:|:..... |.||:. |:|||:.|.:.||:.:.....|.|.:|....:
  Rat   276 VSEMLETLSDDDFVNVASFNSNAQD-VSCFQH-LVQANVRNKKVLKDAVNNITAKGITDYKKGFS 338

  Fly   355 KAFELLEETKLSSRGAQCNQAIMIIGDGAPENNREVFELHNWRDPPYKPVRVFTYLIGKEVANWD 419
            .|||.|....:|.  |.||:.||:..||..|..:|:|..:| :|   |.|||||:.:|:.  |:|
  Rat   339 FAFEQLLNYNVSR--ANCNKIIMLFTDGGEERAQEIFAKYN-KD---KKVRVFTFSVGQH--NYD 395

  Fly   420 --DIRWMACENQGYYVHLSDTAEVREMVLNYIPVMARPLVL-GRHDHPVIWSQVYADIEDTKLSD 481
              .|:||||||:|||..:.....:|.....|:.|:.||:|| |.....|.|:.||.|..:..|  
  Rat   396 RGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGL-- 458

  Fly   482 YLWDINQCEYQKADVLEYWQVHDRMLEPSEMHRRKYRRMKETWNQPVDSNVYQFMTTVSMPIYDR 546
                                                                  :.|.::|::  
  Rat   459 ------------------------------------------------------VITGTLPVF-- 467

  Fly   547 RENALINLTTDINPAAKINLQVTRIANILGVAGTDVPINEIKKLLSPFTLGVNGYAFIVTNNGYV 611
                  |:|........:..|:     ||||.|.||.:.:||:|...|||..|||.|.:..||||
  Rat   468 ------NVTGQSENKTNLKNQL-----ILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYV 521

  Fly   612 LFHPDFRPIFQGYILKPAYNSVDMIEVELLDDDRPARDFNPVLMTIRDSIINQSTGSKWM--LVK 674
            |.||:.:|      ..|  .|.:.:.::.||    |...|.:.:.||:.:|:..:|.|..  |||
  Rat   522 LLHPNLQP------KNP--KSQEPVTLDFLD----AELENDIKVEIRNKMIDGESGEKTFRTLVK 574

  Fly   675 NHFDEMKRVARVKRQYYWTAIKKTPFTLVISYPEQYGVSHMDIRADQEIHRISIKGTNLRSVFSG 739
            :. || :.:.:..|.|.||.:..|.::|.:..| .|...::..:.::.|       |..||    
  Rat   575 SQ-DE-RYIDKGNRTYTWTPVNGTDYSLALVLP-TYSFYYIKAKIEETI-------TQARS---- 625

  Fly   740 KRWKIHPDWLFCKHSNRTFKTPEIELLYFLERMSEPGWRWPGSRSAMPPEHAAAMFSNNSSTGRY 804
            |:.|:        ..:.|.|....|         |.|:.:     ..|.|:...:..::::|...
  Rat   626 KKGKM--------KDSETLKPDNFE---------ESGYTF-----IAPREYCNDLKPSDNNTEFL 668

  Fly   805 PSINE------KESYYCDRQLMQALVFDARVTGWFSNNTSFNSKDDKGTSASSPIAVLMGLLPRN 863
            .:.||      ..:..|:..|:..::.||..|.....|.....|:.||..|              
  Rat   669 LNFNEFIDRKTPNNPSCNTDLINRILLDAGFTNELVQNYWSKQKNIKGVKA-------------- 719

  Fly   864 EFKQRFGVTVAFLATHSGLTRWHEFHSNAAEESGVGETFSQNNTRAIDEIWYKRAVDQHFVREES 928
                      .|:.|..|:||.:        ....||.: |.|....::.:|||::|     .::
  Rat   720 ----------RFVVTDGGITRVY--------PKEAGENW-QENPETYEDSFYKRSLD-----NDN 760

  Fly   929 FVYSVPF--DAGESNSEILVTASHAVFHNEGGKTAPAAVVGFQFQHSALYKLFHNIT------GN 985
            :|::.|:  .:|....|..:..|.||.....||....||||.:...::..:.|...:      |.
  Rat   761 YVFTAPYFNKSGPGAYESGIMVSKAVELYIQGKLLKPAVVGIKIDVNSWIENFTKTSIRDPCAGP 825

  Fly   986 ACAV----DDKDCYILDNNGYVIISTR---VHETGRFFGEVNGAIMKRLLEENVYRQVTVYDYQA 1043
            .|..    |..||.|||:.|:::::..   .::.||||||::.::|:.|:..::|.....||||:
  Rat   826 VCDCKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSMMRHLVNISLYAFNKSYDYQS 890

  Fly  1044 VC---FESKNDNNASSMLLSPLFHLLRVGKWLLHTALWYIVQLLQWAPGVSSHYADMYGDSNDTE 1105
            ||   ...|......|..:..:..:|::| |....|.|.|:|.|                     
  Rat   891 VCDPGAAPKQGAGHRSAYVPSITDILQIG-WWATAAAWSILQQL--------------------- 933

  Fly  1106 PPPPEPHPDHHARNGNGHGKKDDDHWLRYLTLHRTRLKPCDMKRDLYTLFNEKDNVVYNMTAH-- 1168
                                      |..||..|. |:..:|:.|.:|....|.:.:...|.:  
  Rat   934 --------------------------LLSLTFPRL-LEAVEMEEDDFTASLSKQSCITEQTQYFF 971

  Fly  1169 --------------ACERPFVVLPIPFSNLILLVIDQ--LCPRDGSVVLTV-----NPQPIDYHL 1212
                          .|.|.|.|..:..:||:.::::.  .||.|..:::..     .|.|.|   
  Rat   972 KNDTKSFSGLLDCGNCSRIFHVEKLMNTNLVFIMVESKGTCPCDTRLLMQAEQTSDGPDPCD--- 1033

  Fly  1213 SVNDSLACYKQAREFNRMRPHSCISRHANESGIKLCGKACSVYANLGLLLLCHILSRWL 1271
                   ..||.|  .|..|..|...:..|.... ||....:..:|..:.....:..||
  Rat  1034 -------MVKQPR--YRKGPDVCFDNNVLEDYTD-CGGVSGLNPSLWSIFGLQFILLWL 1082

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
stjNP_001246303.1 VWA_N 107..241 CDD:285584 41/135 (30%)
vWA_VGCC_like 253..439 CDD:238740 75/187 (40%)
Cache_1 524..619 CDD:280839 29/94 (31%)
Cacna2d1NP_037051.2 VWA_N 104..223 CDD:285584 41/135 (30%)
vWA_VGCC_like 239..417 CDD:238740 75/187 (40%)
MIDAS-like motif 259..263 2/3 (67%)
Cache_1 446..531 CDD:280839 35/159 (22%)
VGCC_alpha2 543..627 CDD:285647 26/101 (26%)
RAMP_I_III <636..816 CDD:304371 46/231 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166335778
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000496
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10166
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X365
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.940

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