Protein Alignment stj and Cacna2d1

DIOPT Version :10

• Sequence 1: NP_001246303.1
• Gene: stj / 36526
• FlyBaseID: FBgn0261041
• Length: 1271
• Species: Drosophila melanogaster
• Sequence 2: XP_063141674.1
• Gene: Cacna2d1 / 25399
• RGDID: 2247
• Length: 1110
• Species: Rattus norvegicus
• Alignment Length: 1313
• Identity: 331/1313 - (25%)
• Similarity: 542/1313 - (41%)
• Gaps: 325/1313 - (24%)

  Fly    40 VHSWADKLGMELFHL---GDFITRRKEVQESFKDAKVVSRNGA-SIVDSMAKEIEMMMDLKVSAV 100
            :.||.||:..:|..|   ...:|:..::.|.::|...|..|.| .:|:..|::||.::..:..|:
  Rat    33 IKSWVDKMQEDLVTLAKTASGVTQLADIYEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKAL 97

  Fly   101 RRIMDTAENTALSHQ--NDMADKMFSYYSAKEMLEPGDPVPPIPTPAPDMDKDIGEPLIYVQPKV 163
            .|:...||....:||  .|.|.....||:||:.|:|           ...:.:.|...|    |.
  Rat    98 VRLAMEAEKVQAAHQWREDFASNEVVYYNAKDDLDP-----------ERNESESGSQRI----KP 147

  Fly   164 VVLEPRPEFHNTPVNFSVSSVHVPVNVFDRAPDVIKAIQWSENLDQIFRDNYKNDPTLSWQFFGS 228
            |.:|...  ....:::..::||:|.::::.:..|:..:.|:..||::|:.|...||||.||.|||
  Rat   148 VFIEDAN--FGRQISYQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKRNRDEDPTLLWQVFGS 210

  Fly   229 STGFMRQFPASKW----RKDVPVDLYDCRLRSWYMEAATSPKDIVILMDGSGSMLGQRLDIAKHV 289
            :||..|.:|||.|    |....:||||.|.|.||::.|.||||::||:|.|||:.|..|.:.:..
  Rat   211 ATGLARYYPASPWVDNSRTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTS 275

  Fly   290 VNTILDTLGTNDFVNIFTFDKEVSPVVPCFEDTLIQANLGNIRELKEGIELFRPKSIANYTAALT 354
            |:.:|:||..:||||:.:|:..... |.||:. |:|||:.|.:.||:.:.....|.|.:|....:
  Rat   276 VSEMLETLSDDDFVNVASFNSNAQD-VSCFQH-LVQANVRNKKVLKDAVNNITAKGITDYKKGFS 338

  Fly   355 KAFELLEETKLSSRGAQCNQAIMIIGDGAPENNREVFELHNWRDPPYKPVRVFTYLIGKEVANWD 419
            .|||.|....:|.  |.||:.||:..||..|..:|:|..:| :|   |.|||||:.:|:.  |:|
  Rat   339 FAFEQLLNYNVSR--ANCNKIIMLFTDGGEERAQEIFAKYN-KD---KKVRVFTFSVGQH--NYD 395

  Fly   420 --DIRWMACENQGYYVHLSDTAEVREMVLNYIPVMARPLVL-GRHDHPVIWSQVYADIEDTKLSD 481
              .|:||||||:|||..:.....:|.....|:.|:.||:|| |.....|.|:.||.|..:..|
  Rat   396 RGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGL-- 458

  Fly   482 YLWDINQCEYQKADVLEYWQVHDRMLEPSEMHRRKYRRMKETWNQPVDSNVYQFMTTVSMPIYDR 546
                                                                  :.|.::|::
  Rat   459 ------------------------------------------------------VITGTLPVF-- 467

  Fly   547 RENALINLTTDINPAAKINLQVTRIANILGVAGTDVPINEIKKLLSPFTLGVNGYAFIVTNNGYV 611
                  |:|........:..|:     ||||.|.||.:.:||:|...|||..|||.|.:..||||
  Rat   468 ------NVTGQSENKTNLKNQL-----ILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYV 521

  Fly   612 LFHPDF--RPIFQGYILKPAYN-----------------SVDMIEVELLDDDRPARDFNPVLMTI 657
            |.||:.  :||..|.   |..|                 ::|.::.||.:|         :.:.|
  Rat   522 LLHPNLQPKPIGVGI---PTINLRKRRPNVQNPKSQEPVTLDFLDAELEND---------IKVEI 574

  Fly   658 RDSIINQSTGSKWM--LVKNHFDEMKRVARVKRQYYWTAIKKTPFTLVISYPEQYGVSHMDIRAD 720
            |:.:|:..:|.|..  |||:. || :.:.:..|.|.||.:..|.::|.:..| .|...::..:.:
  Rat   575 RNKMIDGESGEKTFRTLVKSQ-DE-RYIDKGNRTYTWTPVNGTDYSLALVLP-TYSFYYIKAKIE 636

  Fly   721 QEIHRISIKGTNLRSVFSGKRWKIHPDWLFCKHSNRTFKTPEIELLYFLERMSEPGWRWPGSRSA 785
            :.|       |..||    |:.|:        ..:.|.|....|         |.|:.:     .
  Rat   637 ETI-------TQARS----KKGKM--------KDSETLKPDNFE---------ESGYTF-----I 668

  Fly   786 MPPEHAAAMFSNNSSTGRYPSINE------KESYYCDRQLMQALVFDARVTGWFSNNTSFNSKDD 844
            .|.|:...:..::::|....:.||      ..:..|:..|:..::.||..|.....|.....|:.
  Rat   669 APREYCNDLKPSDNNTEFLLNFNEFIDRKTPNNPSCNTDLINRILLDAGFTNELVQNYWSKQKNI 733

  Fly   845 KGTSASSPIAVLMGLLPRNEFKQRFGVTVAFLATHSGLTRWHEFHSNAAEESGVGETFSQNNTRA 909
            ||..|                        .|:.|..|:||.:        ....||.: |.|...
  Rat   734 KGVKA------------------------RFVVTDGGITRVY--------PKEAGENW-QENPET 765

  Fly   910 IDEIWYKRAVDQHFVREESFVYSVPF--DAGESNSEILVTASHAVFHNEGGKTAPAAVVGFQFQH 972
            .::.:|||::|     .:::|::.|:  .:|....|..:..|.||.....||....||||.:...
  Rat   766 YEDSFYKRSLD-----NDNYVFTAPYFNKSGPGAYESGIMVSKAVELYIQGKLLKPAVVGIKIDV 825

  Fly   973 SALYKLFHNIT------GNACAV----DDKDCYILDNNGYVIISTR---VHETGRFFGEVNGAIM 1024
            ::..:.|...:      |..|..    |..||.|||:.|:::::..   .::.||||||::.::|
  Rat   826 NSWIENFTKTSIRDPCAGPVCDCKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSMM 890

  Fly  1025 KRLLEENVYRQVTVYDYQAVC---FESKNDNNASSMLLSPLFHLLRVGKWLLHTALWYIVQLLQW 1086
            :.|:..::|.....||||:||   ...|......|..:..:..:|::| |....|.|.|:|.|
  Rat   891 RHLVNISLYAFNKSYDYQSVCDPGAAPKQGAGHRSAYVPSITDILQIG-WWATAAAWSILQQL-- 952

  Fly  1087 APGVSSHYADMYGDSNDTEPPPPEPHPDHHARNGNGHGKKDDDHWLRYLTLHRTRLKPCDMKRDL 1151
                                                         |..||..|. |:..:|:.|.
  Rat   953 ---------------------------------------------LLSLTFPRL-LEAVEMEEDD 971

  Fly  1152 YTLFNEKDNVVYNMTAH----------------ACERPFVVLPIPFSNLILLVIDQ--LCPRDGS 1198
            :|....|.:.:...|.:                .|.|.|.|..:..:||:.::::.  .||.|..
  Rat   972 FTASLSKQSCITEQTQYFFKNDTKSFSGLLDCGNCSRIFHVEKLMNTNLVFIMVESKGTCPCDTR 1036

  Fly  1199 VVLTV-----NPQPIDYHLSVNDSLACYKQAREFNRMRPHSCISRHANESGIKLCGKACSVYANL 1258
            :::..     .|.|.|          ..||.|  .|..|..|...:..|.... ||....:..:|
  Rat  1037 LLMQAEQTSDGPDPCD----------MVKQPR--YRKGPDVCFDNNVLEDYTD-CGGVSGLNPSL 1088

  Fly  1259 GLLLLCHILSRWL 1271
            ..:.....:..||
  Rat  1089 WSIFGLQFILLWL 1101

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
stj	NP_001246303.1	VWA_N	107..241	CDD:462464	41/135 (30%)
		vWA_VGCC_like	253..439	CDD:238740	75/187 (40%)
		dCache_1	<528..624	CDD:460673	31/97 (32%)
		PDC2_MCP_like	586..708	CDD:350337	42/142 (30%)
		VGCC_alpha2	870..>1084	CDD:462488	60/231 (26%)
Cacna2d1	XP_063141674.1	None