DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment stj and cacna2d4b

DIOPT Version :9

Sequence 1:NP_001246303.1 Gene:stj / 36526 FlyBaseID:FBgn0261041 Length:1271 Species:Drosophila melanogaster
Sequence 2:XP_009296274.2 Gene:cacna2d4b / 100150428 ZFINID:ZDB-GENE-100422-18 Length:1100 Species:Danio rerio


Alignment Length:1324 Identity:384/1324 - (29%)
Similarity:627/1324 - (47%) Gaps:309/1324 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 WRLCLGLLSVLVCLAPCVNLQ-PAENINYNLVHSWADKLGMELFHLGDFITRRKEVQESFKDAKV 73
            |...|.|.:..:|:.....:: |.|.     |..||..:..::..:....:.....|:..||.:.
Zfish     9 WVTFLLLSTGWMCMFTHAQMKIPPET-----VQKWALTISEQINAIASKYSGAALFQKKLKDVEP 68

  Fly    74 VSR----NGASIVDSMAKEIEMMMDLKVSAVRRIMDTAENTALSHQNDMADKMFSYYSA------ 128
            :.|    :|:.:|...|:|||.|:..|:.:.:|:.||||:..|.|:.: :...|.|::|      
Zfish    69 IIRIEDLDGSELVLEFAEEIERMLGSKMRSAKRLADTAEDADLYHEFN-SSLQFDYFNALLVNTM 132

  Fly   129 ---KEMLEPGDPVPPIPTPAPDMDKDIGEPLIYVQPKVVVLEPRPEFHNTPVNFSVSSVHVPVNV 190
               ...:|.|...|                          ||....|....||..:|.:.||.||
Zfish   133 DEEGNFIELGGEFP--------------------------LEENNHFSKLAVNTLMSDIQVPTNV 171

  Fly   191 FDRAPDVIKAIQWSENLDQIFRDNYKNDPTLSWQFFGSSTGFMRQFPASKWRKDV-PVDLYDCRL 254
            :::.||::..:..||.|:.||.:|::.||||:||:|.|.|||.|.:|..:|..|. .|..:|||.
Zfish   172 YNKDPDILNGVYMSEALNDIFINNFQKDPTLTWQYFCSQTGFFRLYPGIRWTPDANGVVSFDCRN 236

  Fly   255 RSWYMEAATSPKDIVILMDGSGSMLGQRLDIAKHVVNTILDTLGTNDFVNIFTFDKEVSPVVPCF 319
            |:||::|||||||:||::|.||||.|.::.||||.:||||||||.|||||:..:...||.|.|||
Zfish   237 RNWYIQAATSPKDLVIVVDVSGSMKGLKMTIAKHTINTILDTLGENDFVNVIAYTDYVSYVEPCF 301

  Fly   320 EDTLIQANLGNIRELKEGIELFRPKSIANYTAALTKAFELLEETKLSSRGAQCNQAIMIIGDGAP 384
            :.||:||:|.|....|..::....|..|....|:.::|.:|.:.:.:.:|:.||||||:|.|||.
Zfish   302 KGTLVQADLDNREHFKLLVDELHVKGEAKVKKAMKESFRILADARANGQGSLCNQAIMLITDGAM 366

  Fly   385 ENNREVFELHNWRDPPYKPVRVFTYLIGKEVANWDDIRWMACENQGYYVHLSDTAEVREMVLNYI 449
            |:.:.|||..||   |.|.|||||||||:::...::::|:||.|:|:|.|:|..|:|:|.|:.|:
Zfish   367 EDFQSVFEEFNW---PDKKVRVFTYLIGRDMTFSENVKWIACNNKGFYAHVSTLADVQENVMEYL 428

  Fly   450 PVMARPLVLGRHDHPVIWSQVYADIEDTKLSDYLWDINQCEYQKADVLEYWQVHDRMLEPSEMHR 514
            .|::||:|: .|||.:||::.|.|                     .||           |:.|  
Zfish   429 HVLSRPMVI-NHDHDIIWTEAYMD---------------------SVL-----------PNTM-- 458

  Fly   515 RKYRRMKETWNQPVDSNVYQFMTTVSMPIYDRRENALINLTTDINPAAKINLQVTRIANILGVAG 579
                   |.:.....|.:  |||:|:||::.:::..|.:                  ..:|||.|
Zfish   459 -------EVFKSKAHSLL--FMTSVAMPVFSKKKETLSH------------------GILLGVVG 496

  Fly   580 TDVPINEIKKLLSPFTLGVNGYAFIVTNNGYVLFHPDFRPI-FQGYILKPA--YNSVDMIEVELL 641
            ||:|:.|:.||...:.||.:||||::|||||:|.|||.||: ::|..|||.  |||||:.|.|..
Zfish   497 TDIPLLEVMKLAPRYKLGAHGYAFLITNNGYILAHPDLRPLYYEGKKLKPKPNYNSVDLSEAEWE 561

  Fly   642 DDDRPARDFNPVLMTIRDSIINQSTGSKWMLVKNHFDEMKRVARVKRQYYWTAIKKTPFTLVISY 706
            |.:.          .:|.:::...||:..:.|:...|:.||...:|..|::|.|.:|||:..:..
Zfish   562 DTED----------NLRTAMVKGETGTLALDVRTAVDKGKRPLFLKNDYFYTTIDETPFSFGMVL 616

  Fly   707 PEQYGVSHM---DIRADQEIHRISIKGTNLRSVFSGKRWKIHPDWLFCKHSNRTFKTPEIELLYF 768
            .:.:| .:|   ::..::.:|  .::..:|         .|..:|.:|:                
Zfish   617 TKGHG-QYMFFGNVSVEEGLH--DLQQPDL---------TIAEEWTYCE---------------- 653

  Fly   769 LERMSEPGWRWPGSRSAMPPEH-------AAAMFSNNSSTGRYPSINEKESYYCDRQLMQALVFD 826
                           :.:.|:|       |...:    .||:.|.:.      ||..|:|.::||
Zfish   654 ---------------TDIDPQHRKLNQLQAVVRY----LTGKEPELE------CDEILLQQVLFD 693

  Fly   827 ARVTG-----WFSNNTSFNSKDDKGTSASSPIAVLMGLLPRNEFKQRFGVTVAFLATHSGLTRWH 886
            |.||.     |.....:....|:                         |:..|||.|.||:.|..
Zfish   694 AVVTAPLEAYWTRLTLTPPGVDE-------------------------GMESAFLGTRSGVLRVI 733

  Fly   887 EFHSNAAEESGVGETF----SQNNTRAIDE--IWYKRAVDQHFVREESFVYSVPFD---AGESNS 942
            .:   ...|..:|:.|    .:.|...:|.  |||:.|.:.   ....|::.||:|   .|: |:
Zfish   734 RY---TGIEKRLGKKFLTRVDKENLFTVDHFPIWYRLAAEN---TPGQFLFYVPYDDINKGK-NT 791

  Fly   943 EILVTASHAVFHNEGGKTAPAAVVGFQFQHSALYKLFHNITGN---------------ACAVDDK 992
            .:.||   :|...|..:||.|..:|.|.....|.::|.:|...               :|...|.
Zfish   792 FVAVT---SVTVTERKRTAIAGAIGMQASLDVLERIFMSIAKQPNDTDCNDVEGICPLSCESIDL 853

  Fly   993 DCYILDNNGYVIISTRVHETGRFFGEVNGAIMKRLLEENVYRQVTVYDYQAVCFESKNDNNASSM 1057
            :||::|:||::::|....:.||||||::|::|.:||:..:|::||:|||||:|....:.::.:..
Zfish   854 NCYLVDSNGFILMSKDRGDVGRFFGEIDGSVMAQLLKSGLYKRVTLYDYQAMCKTGHHHSSGARP 918

  Fly  1058 LLSPLFHLLRVGKWLLHTALWYIVQLLQWAPGVSSHYADMYGDSNDTEPPPPEPHPDHHARNGNG 1122
            ||||.:.||.:.||      |:            ||:.....:.|..               |..
Zfish   919 LLSPFYALLALIKW------WF------------SHFVMFMLEFNIC---------------GLW 950

  Fly  1123 HGKKDDDHWLRYLTLHRTR----LKPCDMKRDLYTLF------NEKDNVVYNMTAHACERPFVVL 1177
            |.....|....:.|.|:.:    ::||:.:   |..|      .|.::::   ....|::.||:.
Zfish   951 HNDYVVDAKAGFHTTHKQKKVELMQPCNTE---YPGFMYDKSIRETNSII---KCGRCQKMFVLQ 1009

  Fly  1178 PIPFSNLILLVI--DQLCPRDGSVVLTVNPQPIDYHLSVNDSLACYKQAREFNRMRPHSCISRHA 1240
            .||.|||::||:  |..|.|..:.: |:.|:.:.|    |.::.|.:...:..|.||.||.|.||
Zfish  1010 QIPNSNLVMLVVQADCDCSRQYAPI-TLMPKEVKY----NATVKCNRMKSQKIRRRPESCHSYHA 1069

  Fly  1241 NESGIKLCGKACSVYANLGLLLLC 1264
            :|:. :.||.||.:..:|.|..:|
Zfish  1070 HENA-EDCGGACGITLSLTLYFIC 1092

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
stjNP_001246303.1 VWA_N 107..241 CDD:285584 41/142 (29%)
vWA_VGCC_like 253..439 CDD:238740 90/185 (49%)
Cache_1 524..619 CDD:280839 33/94 (35%)
cacna2d4bXP_009296274.2 VWA_N 112..222 CDD:312040 38/136 (28%)
vWA_VGCC_like 235..418 CDD:238740 90/185 (49%)
dCache_1 414..>533 CDD:308398 53/180 (29%)
VGCC_alpha2 650..1028 CDD:312092 113/492 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170575000
Domainoid 1 1.000 159 1.000 Domainoid score I4044
eggNOG 1 0.900 - - E1_KOG2353
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 572 1.000 Inparanoid score I1017
OMA 1 1.010 - - QHG45864
OrthoDB 1 1.010 - - D110668at33208
OrthoFinder 1 1.000 - - FOG0000496
OrthoInspector 1 1.000 - - mtm6553
orthoMCL 1 0.900 - - OOG6_103783
Panther 1 1.100 - - O PTHR10166
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X365
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
1413.770

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