Protein Alignment stj and cacna2d1

DIOPT Version :10

• Sequence 1: NP_001246303.1
• Gene: stj / 36526
• FlyBaseID: FBgn0261041
• Length: 1271
• Species: Drosophila melanogaster
• Sequence 2: NP_001090738.1
• Gene: cacna2d1 / 100036724
• XenbaseID: XB-GENE-964524
• Length: 1076
• Species: Xenopus tropicalis
• Alignment Length: 1314
• Identity: 336/1314 - (25%)
• Similarity: 549/1314 - (41%)
• Gaps: 295/1314 - (22%)

  Fly     6 LLAWWRLCLGLL---SVLVCLAPCVNLQPAENINY---NLVHSWADKLGMELFHLGDFITRRKEV 64
            :.|.|.|...|.   |:|:|        |:....:   :.:..|.:|:..:|..|....:...::
 Frog     1 MAASWLLIFSLTLFQSLLIC--------PSSEEYFPSASTIKQWVEKMQNDLVTLARTASGVDQL 57

  Fly    65 QESFKDAK----VVSRNGASIVDSMAKEIEMMMDLKVSAVRRIMDTAENTALSHQ--NDMADKMF 123
            .|.:...:    |.:.|...:|.|.|..||.::..:..|:..:...||....|||  :.......
 Frog    58 SEIYLKNRHLYTVEANNARQLVQSAATNIEKLLRNRSKALVHLAKKAEEIQESHQWRDQFGTNSI 122

  Fly   124 SYYSAKEMLEPGDPVPPIPTPAPDMDKDIGEPLIYVQPKVVVLEPRPEFHNTPVNFSVSSVHVPV 188
            .||:||:     |.:.|....:....:.|       :|   ||:..|.|.. ..::..|:||:|.
 Frog   123 VYYNAKD-----DQMDPEKNDSDSASQKI-------KP---VLQDDPVFRR-QTSYQHSAVHIPT 171

  Fly   189 NVFDRAPDVIKAIQWSENLDQIFRDNYKNDPTLSWQFFGSSTGFMRQFPASKW----RKDVPVDL 249
            ::::.:..|:..:.|:..||::|:.|.:.|.||.||.|||:||..|.:|||.|    |....:||
 Frog   172 DIYEGSTIVLNELNWTAALDEVFKKNREEDETLLWQVFGSATGLARYYPASPWVDKSRTANKIDL 236

  Fly   250 YDCRLRSWYMEAATSPKDIVILMDGSGSMLGQRLDIAKHVVNTILDTLGTNDFVNIFTFDKEVSP 314
            ||.|.|.||::.|.||||::||:|.|||:.|..|.:.:..|:.:|:||..:||||:..|:.....
 Frog   237 YDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVAAFNNNAHD 301

  Fly   315 VVPCFEDTLIQANLGNIRELKEGIELFRPKSIANYTAALTKAFELLEETKLSSRGAQCNQAIMII 379
             |.|| :.|:|||:.|.::|||.:.....|...:|......||:.|....:|.  |.||:.||:.
 Frog   302 -VSCF-NHLVQANVRNKKKLKEAVNNITAKGTTDYKTGFKFAFDQLLNHNVSR--ANCNKIIMLF 362

  Fly   380 GDGAPENNREVFELHNWRDPPYKPVRVFTYLIGKEVANWD--DIRWMACENQGYYVHLSDTAEVR 442
            .||..:..:|.||.:| :|   |.|||||:.:|:.  |:|  .|:||||:|:|:|..:.....:|
 Frog   363 TDGGEDKAKETFEAYN-KD---KTVRVFTFSVGQH--NYDKGPIQWMACQNKGFYYEIPSIGAIR 421

  Fly   443 EMVLNYIPVMARPLVL-GRHDHPVIWSQVYADIEDTKLSDYLWDINQCEYQKADVLEYWQVHDRM 506
            .....|:.|:.||:|| |.....|.|:.||.|..:..|
 Frog   422 INTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGL--------------------------- 459

  Fly   507 LEPSEMHRRKYRRMKETWNQPVDSNVYQFMTTVSMPIYDRRENALINLTTDINPAAKINLQVTRI 571
                                         :.|.::|::        |||.|.| ..|..|
 Frog   460 -----------------------------VITGTLPVF--------NLTVDHN-GKKNQL----- 481

  Fly   572 ANILGVAGTDVPINEIKKLLSPFTLGVNGYAFIVTNNGYVLFHPDFRPIFQGYILK---PAYNSV 633
              ||||.|.||.:.:||:|...|||..|||.|.:..|||||.||:.:|    ..||   |.  ::
 Frog   482 --ILGVMGVDVSLEDIKRLTPRFTLCPNGYYFALDPNGYVLLHPNLQP----KDLKSQEPV--TL 538

  Fly   634 DMIEVELLDDDRPARDFNPVLMTIRDSIINQSTGSKWM--LVKNHFDEMKRVARVKRQYYWTAIK 696
            |.::.||.:|.:         :.||..:|:..:|....  |||:. || :.:.|..|.|.|..:.
 Frog   539 DFLDAELENDHK---------VEIRTKMIDLESGESTFQTLVKSQ-DE-RYIDRGNRTYTWGPVT 592

  Fly   697 KTPFTLVISYPEQYGVSHMDIRADQEIHRISIKGTNLRSVFSGKRWKIHPDWLFCKHSNRTFKTP 761
            .|.::|.:..| .||..::....::.:       |..:|    ||:||        ..:.|.|
 Frog   593 GTDYSLGLVLP-SYGFYYIKAAFEESM-------TQAKS----KRFKI--------QDSETLK-- 635

  Fly   762 EIELLYFLERMSEPGWRWPGSRSAMPPEHAAAMFSNNSSTGRYPSINE------KESYYCDRQLM 820
                   ||...|.|:.:     ..|.|:...:..:.::|....:.|.      ..|..|:..::
 Frog   636 -------LEHFEETGYTF-----LAPREYCTDLKISTNNTEFLLNFNSFIDRKTPNSPSCNTDMV 688

  Fly   821 QALVFDARVT------GWFSNNTSFNSKDDKGTSASSPIAVLMGLLPRNEFKQRFGVTVAFLATH 879
            ..::.||..|      .|            ||.|            |:       |:...|:||.
 Frog   689 NRVLLDAGFTFELAQLHW------------KGQS------------PK-------GILARFVATD 722

  Fly   880 SGLTRWHEFHSNAAEESGVGETFSQNNTRAIDEIWYKRAVDQHFVREESFVYSVPF----DAGES 940
            .|:||.:        .|..||.:.: :....:..:|||::|     .:::|::.|:    ....:
 Frog   723 GGITRVY--------PSFAGEDWPE-DPETYEGSFYKRSLD-----NDNYVFTAPYFNKTRGSRA 773

  Fly   941 NSEILVTASHAVFHNEGGKTAPAAVVGFQFQHSALYKLFHNITGNACAVDDKDCYILDNNGYVII 1005
            :|.|:|  |.|:.....||....||||.:..   :.....|.|.:.......||.|||:.|::::
 Frog   774 DSGIMV--SKAIEITIDGKLLKPAVVGIKID---VNSWMENFTRDTTKNPQLDCVILDDGGFLLM 833

  Fly  1006 STR---VHETGRFFGEVNGAIMKRLLEENVYRQVTVYDYQAVCFESKNDNNAS---SMLLSPLFH 1064
            |.:   :.:.||||||::.::|::|:..:||.....||||:||.:.......:   |:.:..:..
 Frog   834 SNQEDHITQIGRFFGEIDPSLMRQLVNISVYAFNKSYDYQSVCDQGDEPVKTAATRSVFVPTIAD 898

  Fly  1065 LLRVGKWLLHTALWYIVQLLQWAPGVSSHYADMYGDSNDTEPPPPEPHPDHHARNGNGHGKKDDD 1129
            :|.:| |....|.|.|:|.|.|               :.|.|...|.            .:.|||
 Frog   899 ILNLG-WWASAAAWSIMQQLFW---------------SITFPRFLEA------------AEFDDD 935

  Fly  1130 HWLRYLTLHRTRLKPCDMKRDLYTLFNEKDNVVYN--MTAHACERPFVVLPIPFSNLILLVIDQL 1192
            .:....:.|     .|..::..|  |.|.||..::  :....|.|.:.|..|..:||:.::||..
 Frog   936 DFSSDQSKH-----SCITEQTQY--FFENDNRSFSGYLDCVNCSRIYHVEKILNTNLVFIIIDST 993

  Fly  1193 CPRDGSVVLTVNPQPIDYHLSVNDSLACYKQAREFNRMRPHSCISRHANESGIKLCGKACSVYAN 1257
            ...|.    ..|...|......|....|........|..|..|..:...|.... ||....:..:
 Frog   994 LTCDA----CDNQALIQAEQRSNGPNPCLLAQTPRYRKGPDLCFDQDVGEDDTD-CGGVSGLTPS 1053

  Fly  1258 LGLLLLCHILSRWL 1271
            |..::...::..||
 Frog  1054 LWSMIGIQLVLLWL 1067

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
stj	NP_001246303.1	VWA_N	107..241	CDD:462464	41/135 (30%)
		vWA_VGCC_like	253..439	CDD:238740	72/187 (39%)
		dCache_1	<528..624	CDD:460673	34/95 (36%)
		PDC2_MCP_like	586..708	CDD:350337	40/126 (32%)
		VGCC_alpha2	870..>1084	CDD:462488	60/223 (27%)
cacna2d1	NP_001090738.1	VWA_N	104..224	CDD:462464	41/135 (30%)
		vWA_VGCC_like	240..418	CDD:238740	72/187 (39%)
		dCache_1	<436..557	CDD:460673	52/207 (25%)
		HK_sensor	507..603	CDD:365792	34/112 (30%)
		VGCC_alpha2	630..1045	CDD:462488	112/518 (22%)