Protein Alignment tei and Nectin1

DIOPT Version :10

• Sequence 1: NP_523731.2
• Gene: tei / 36521
• FlyBaseID: FBgn0000633
• Length: 822
• Species: Drosophila melanogaster
• Sequence 2: NP_067399.2
• Gene: Nectin1 / 58235
• MGIID: 1926483
• Length: 515
• Species: Mus musculus
• Alignment Length: 311
• Identity: 68/311 - (21%)
• Similarity: 115/311 - (36%)
• Gaps: 74/311 - (23%)

  Fly   295 NGALTITNVMLEDDGKWQCE--------AENTRRYTENARPVKLVVLDRPKPPYLLIDSRRLDAS 351
            :|.:.::.:.|||:|.:.||        .|:....|..|:|...:...|     .::.:|:
Mouse   106 DGTIRLSGLELEDEGMYICEFATFPTGNRESQLNLTVMAKPTNWIEGTR-----AVLRARK---- 161

  Fly   352 NLFVPVKENSELNLACVSEGGNPRPTLTWEVLLSPGVDRHAQKVSAEVLELEEIKGEKLDKDGYK 416
                 .:::..|...|.|..|.|...::||..|         |..||..|:....|.......|:
Mouse   162 -----GQDDKVLVATCTSANGKPPSAVSWETRL---------KGEAEYQEIRNPNGTVTVISRYR 212

  Fly   417 INSGAKSEARLPAVYRAHHNARILCVMEHPTLKIRQNASLLLDVQYTPSFAISRTPGFGYPLREG 481
            :         :|:  |..|...:.|::.:...:.|:  ||.|:|||.|...|....|..|..|
Mouse   213 L---------VPS--REAHRQSLACIVNYHLDRFRE--SLTLNVQYEPEVTIEGFDGNWYLQR-- 262

  Fly   482 IEVSLKCDVDSNPPSTP-RWQKDDGDTPVPQTGDGFLNFTSIRREHSGWYKCTSRHLNFQ----Y 541
            .:|.|.|..|:|||:|. .|...:|..|                  .| .:..:|.|.|:    |
Mouse   263 TDVKLTCKADANPPATEYHWTTLNGSLP------------------KG-VEAQNRTLFFRGPITY 308

  Fly   542 SSIGYYLSVRFDSVDVTSEPDDQDVS----VAAASHNPNKGQLEVQLGGAV 588
            |..|.|:....:.:...|...:.:::    .....|....||:...:.|.|
Mouse   309 SLAGTYICEATNPIGTRSGQVEVNITEFPYTPTPEHGRRAGQMPTAIIGGV 359

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tei	NP_523731.2	IG_like	244..332	CDD:214653	11/44 (25%)
		Ig strand B	254..258	CDD:409353
		Ig strand C	267..271	CDD:409353
		Ig strand E	296..300	CDD:409353	1/3 (33%)
		Ig strand F	310..315	CDD:409353	2/12 (17%)
		Ig strand G	326..329	CDD:409353	1/2 (50%)
		Ig	359..452	CDD:472250	18/92 (20%)
		Ig_3	478..533	CDD:464046	13/55 (24%)
		IG_like	578..660	CDD:214653	4/11 (36%)
Nectin1	NP_067399.2	IgV_1_Nectin-1_like	31..143	CDD:409469	9/36 (25%)
		FR1	31..54	CDD:409469
		Ig strand A	31..35	CDD:409469
		Ig strand A'	37..41	CDD:409469
		Ig strand B	46..54	CDD:409469
		CDR1	55..62	CDD:409469
		FR2	63..69	CDD:409469
		Ig strand C	64..69	CDD:409469
		CDR2	70..89	CDD:409469
		Ig strand C'	79..84	CDD:409469
		Ig strand C'	86..90	CDD:409469
		FR3	90..128	CDD:409469	7/21 (33%)
		Ig strand D	97..101	CDD:409469
		Ig strand E	106..113	CDD:409469	1/6 (17%)
		Ig strand F	120..128	CDD:409469	3/7 (43%)
		CDR3	129..132	CDD:409469	0/2 (0%)
		Ig strand G	132..142	CDD:409469	1/9 (11%)
		FR4	133..143	CDD:409469	2/9 (22%)
		IgC1_2_Nectin-1_like	146..243	CDD:143298	25/132 (19%)
		Ig strand A	146..152	CDD:143298	1/5 (20%)
		Ig strand B	168..175	CDD:143298	2/6 (33%)
		Ig strand C	180..186	CDD:143298	0/5 (0%)
		Ig strand C'	188..190	CDD:143298	1/10 (10%)
		Ig strand D	191..199	CDD:143298	3/7 (43%)
		Ig strand E	205..213	CDD:143298	1/7 (14%)
		Ig strand F	223..230	CDD:143298	1/6 (17%)
		Ig strand G	234..240	CDD:143298	2/7 (29%)
		Ig	247..333	CDD:472250	25/106 (24%)
		Ig strand B	265..269	CDD:409524	2/3 (67%)
		Ig strand C	279..283	CDD:409524	0/3 (0%)
		Interaction with FGFR. /evidence=ECO:0000269|PubMed:22955284	282..299		4/35 (11%)
		Ig strand E	298..302	CDD:409524	2/3 (67%)
		Ig strand F	313..318	CDD:409524	1/4 (25%)
		Ig strand G	330..333	CDD:409524	0/2 (0%)
		TM_EGFR-like	353..382	CDD:213052	2/7 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	399..486