Protein Alignment tei and PVR

DIOPT Version :10

• Sequence 1: NP_523731.2
• Gene: tei / 36521
• FlyBaseID: FBgn0000633
• Length: 822
• Species: Drosophila melanogaster
• Sequence 2: NP_006496.4
• Gene: PVR / 5817
• HGNCID: 9705
• Length: 417
• Species: Homo sapiens
• Alignment Length: 231
• Identity: 51/231 - (22%)
• Similarity: 85/231 - (36%)
• Gaps: 65/231 - (28%)

  Fly   295 NGALTITNVMLEDDGKWQCEAENTRRYTENARPVK--LVVLDRPKPPYLLIDSRRLDASNLFVPV 357
            |.:|.:..:.:||:|.:.|....   :.:.:|.|.  |.||.:|:.   ..:.:::..:...||:
Human   105 NASLRMFGLRVEDEGNYTCLFVT---FPQGSRSVDIWLRVLAKPQN---TAEVQKVQLTGEPVPM 163

  Fly   358 KENSELNLACVSEGGNPRPTLTWEVLLS--PGVDRHAQKVSAEV--------LELEEIKGEKLDK 412
            ..       |||.||.|...:||...|.  |...:....:|..|        :...::.|:
Human   164 AR-------CVSTGGRPPAQITWHSDLGGMPNTSQVPGFLSGTVTVTSLWILVPSSQVDGK---- 217

  Fly   413 DGYKINSGAKSEARLPAVYRAHHNARILCVMEHPTLKIRQNASLLLDVQYTPSFAISRTPGFGYP 477
                                     .:.|.:||.:.:..|..::.|.|.|.|..:||     ||.
Human   218 -------------------------NVTCKVEHESFEKPQLLTVNLTVYYPPEVSIS-----GYD 252

  Fly   478 ----LREGIEVSLKCDVDSNP-PSTPRWQKDDGDTP 508
                |.:. |.:|.||..||| |:...|....|..|
Human   253 NNWYLGQN-EATLTCDARSNPEPTGYNWSTTMGPLP 287

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tei	NP_523731.2	IG_like	244..332	CDD:214653	9/38 (24%)
		Ig strand B	254..258	CDD:409353
		Ig strand C	267..271	CDD:409353
		Ig strand E	296..300	CDD:409353	1/3 (33%)
		Ig strand F	310..315	CDD:409353	1/4 (25%)
		Ig strand G	326..329	CDD:409353	1/2 (50%)
		Ig	359..452	CDD:472250	16/102 (16%)
		Ig_3	478..533	CDD:464046	12/32 (38%)
		IG_like	578..660	CDD:214653
PVR	NP_006496.4	IgV_1_Nectin-2_NecL-5_like_CD112_CD155	29..141	CDD:409581	9/38 (24%)
		FR1	29..52	CDD:409581
		Ig strand A	29..33	CDD:409581
		Ig strand A'	35..39	CDD:409581
		Ig strand B	44..52	CDD:409581
		CDR1	53..61	CDD:409581
		FR2	62..68	CDD:409581
		Ig strand C	63..68	CDD:409581
		CDR2	69..86	CDD:409581
		Ig strand C'	76..81	CDD:409581
		Ig strand C'	83..86	CDD:409581
		FR3	87..127	CDD:409581	6/21 (29%)
		Ig strand D	91..97	CDD:409581
		Ig strand E	105..112	CDD:409581	2/6 (33%)
		Ig strand F	119..127	CDD:409581	2/7 (29%)
		CDR3	128..131	CDD:409581	0/2 (0%)
		Ig strand G	131..141	CDD:409581	3/9 (33%)
		FR4	132..141	CDD:409581	3/8 (38%)
		IgC1_2_Nectin-2_Necl-5_like	145..241	CDD:409500	21/134 (16%)
		Ig strand A	145..151	CDD:409500	1/8 (13%)
		Ig strand B	162..169	CDD:409500	3/13 (23%)
		Ig strand C	174..180	CDD:409500	1/5 (20%)
		Ig strand C'	182..184	CDD:409500	0/1 (0%)
		Ig strand D	187..195	CDD:409500	1/7 (14%)
		Ig strand E	200..208	CDD:409500	1/7 (14%)
		Ig strand F	218..225	CDD:409500	1/6 (17%)
		Ig strand G	231..237	CDD:409500	1/5 (20%)
		Ig3_Nectin-5_like	244..329	CDD:409524	17/50 (34%)
		Ig strand A	244..250	CDD:409524	3/10 (30%)
		Ig strand B	262..266	CDD:409524	1/3 (33%)
		Ig strand C	276..281	CDD:409524	1/4 (25%)
		Ig strand C'	283..286	CDD:409524	1/2 (50%)
		Ig strand D	289..294	CDD:409524
		Ig strand E	295..301	CDD:409524
		Ig strand F	306..316	CDD:409524
		Ig strand G	319..329	CDD:409524
		DYNLT1 binding	368..372
		ITIM motif	396..401