DRSC/TRiP Functional Genomics Resources

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Protein Alignment tei and NPHS1

DIOPT Version :10

Sequence 1:NP_523731.2 Gene:tei / 36521 FlyBaseID:FBgn0000633 Length:822 Species:Drosophila melanogaster
Sequence 2:NP_004637.1 Gene:NPHS1 / 4868 HGNCID:7908 Length:1241 Species:Homo sapiens


Alignment Length:778 Identity:160/778 - (20%)
Similarity:253/778 - (32%) Gaps:248/778 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 NINAKSVQK-----------PKPSERREVISTSSSSSHSWPSISA------------EPADEVVD 69
            |:|..|.||           |:.|:.|:::...:||    |::.|            .|...|::
Human   186 NVNEGSQQKLFTVEATARVTPRSSDNRQLLVCEASS----PALEAPIKASFTVNVLFPPGPPVIE 246

  Fly    70 HRG-------------------GGKP---AKCAKNCQKAKAKWAKWRTQ----------LKPHHQ 102
            ..|                   ||.|   .:..||.|.....|....||          ::|  :
Human   247 WPGLDEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRP--E 309

  Fly   103 AHRAVQHKEARQRQRRETEEDELDAVLRAPSSTSTSTAVATTVQATSSSSSATRSSVINETKAKR 167
            .|.|....||.......|:|..:...:..|.|.......|:..:    :.:.|.|.|   :|:.|
Human   310 DHGAQLSCEAHNSVSAGTQEHGITLQVTFPPSAIIILGSASQTE----NKNVTLSCV---SKSSR 367

  Fly   168 PRSTLHLAPEDMQPKPKEPVIIIDDVEEFDSGTSTSDLIARKSRE------EAEEEEDEGPLEPR 226
            ||..|.......|..|.|.. ::|.:.......|....:||:...      ||..|........:
Human   368 PRVLLRWWLGWRQLLPMEET-VMDGLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKK 431

  Fly   227 VLPLRPVPP-------NPYEAEEMSVVYAEQHSEIKLMCEVDLDIA-----TSMWYKNGQVVHAM 279
            .|.|....|       .|.|.:::     ...:.::|:|   |.|.     :.||||:.:.    
Human   432 SLILNVKYPAQKLWIEGPPEGQKL-----RAGTRVRLVC---LAIGGNPEPSLMWYKDSRT---- 484

  Fly   280 DRTARVTDYRFIKEA----------NGALTITNVML-----EDDGKWQCEAENTRRYTENA---R 326
                 ||:.|..:|:          :|:.....::|     ::..|:.|:|......|:.|   .
Human   485 -----VTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKAGQLSASTQLAVQFP 544

  Fly   327 PVKLVVLDRPKPPYLLIDSRRLDASNLFVPVKENSELNLACVSEGGNPRPTLTWEVLLSPGVDRH 391
            |..:.:|              .:||.|    :....|||.|||...||...|:|           
Human   545 PTNVTIL--------------ANASAL----RPGDALNLTCVSVSSNPPVNLSW----------- 580

  Fly   392 AQKVSAEVLELEEIKGEKLDKDGYKINSGAKSEARLP------------AVYRAHHNARILCVME 444
                               ||:|.::...|....|.|            .|....|..|:.|...
Human   581 -------------------DKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAH 626

  Fly   445 HPTLKIRQNASLLLDVQYTPSFAISRTPGFGYPLREGI---------EVSLKCDVDSNP-PSTPR 499
            ...|:...::...|:|.|.|.|           |.|.:         |..|...|.:|| |....
Human   627 SAELRETVSSFYRLNVLYRPEF-----------LGEQVLVVTAVEQGEALLPVSVSANPAPEAFN 680

  Fly   500 WQKDDGDTPVPQTG-------DGFLNFTSIRREHSGWYKCTSRHLNFQYSSIGYYLSVRFDSVDV 557
            | ...|....|..|       .|.|:..::.|...|.|:     |:.|.|.......:|   :||
Human   681 W-TFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQ-----LHCQNSEGTAEARLR---LDV 736

  Fly   558 TSEPDDQDVSVAAASHNPNKGQLEVQLGGAVTLQCPQGS------LGCWSHL--DPISARLRGLG 614
            ...|      ...|..:|.    ||.:||:|.:.|...:      :..|..|  |.....|..:.
Human   737 HYAP------TIRALQDPT----EVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDME 791

  Fly   615 YGSSQPTGQFSLKDVMYQDAGMYKCV---GQSPTNKKKLEVLQSVTVSVKGAPTVMALNATPV 674
            ..|..|||:..:.......||.|:|:   |.:|..::.|.::      |:.||.|.  :.||:
Human   792 KISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLV------VRFAPQVE--HPTPL 846

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
teiNP_523731.2 IG_like 244..332 CDD:214653 20/110 (18%)
Ig strand B 254..258 CDD:409353 1/3 (33%)
Ig strand C 267..271 CDD:409353 2/3 (67%)
Ig strand E 296..300 CDD:409353 1/3 (33%)
Ig strand F 310..315 CDD:409353 2/4 (50%)
Ig strand G 326..329 CDD:409353 1/2 (50%)
Ig 359..452 CDD:472250 21/104 (20%)
Ig_3 478..533 CDD:464046 17/71 (24%)
IG_like 578..660 CDD:214653 21/92 (23%)
NPHS1NP_004637.1 V-set 38..119 CDD:462230
C2-set_2 141..228 CDD:400489 12/45 (27%)
Ig strand B 156..160 CDD:409353
Ig strand C 170..174 CDD:409353
Ig strand E 200..204 CDD:409353 0/3 (0%)
Ig strand F 214..219 CDD:409353 0/4 (0%)
Ig strand G 229..232 CDD:409353 0/2 (0%)
Ig 237..336 CDD:472250 19/100 (19%)
Ig strand B 261..265 CDD:409353 0/3 (0%)
Ig strand C 275..279 CDD:409353 0/3 (0%)
Ig strand E 300..304 CDD:409353 0/3 (0%)
Ig strand F 314..319 CDD:409353 0/4 (0%)
Ig strand G 332..335 CDD:409353 0/2 (0%)
Ig 345..424 CDD:472250 19/86 (22%)
Ig strand B 357..361 CDD:409353 1/3 (33%)
Ig strand C 371..375 CDD:409353 1/3 (33%)
Ig strand E 400..404 CDD:409353 1/3 (33%)
Ig strand F 414..419 CDD:409353 0/4 (0%)
Ig strand G 430..433 CDD:409353 0/2 (0%)
Ig 446..541 CDD:472250 20/111 (18%)
Ig strand B 461..465 CDD:409353 1/3 (33%)
Ig strand C 475..479 CDD:409353 1/3 (33%)
Ig strand E 510..515 CDD:409353 0/4 (0%)
Ig strand F 525..530 CDD:409353 2/4 (50%)
Ig 549..632 CDD:472250 25/130 (19%)
Ig strand B 563..567 CDD:409353 3/3 (100%)
Ig strand C 577..581 CDD:409353 2/33 (6%)
Ig strand E 606..610 CDD:409353 0/3 (0%)
Ig strand F 620..625 CDD:409353 2/4 (50%)
Ig strand G 635..638 CDD:409353 0/2 (0%)
Ig 646..736 CDD:472250 23/109 (21%)
Ig strand B 664..668 CDD:409353 1/3 (33%)
Ig strand C 678..682 CDD:409353 1/4 (25%)
Ig strand E 702..706 CDD:409353 2/3 (67%)
Ig strand F 716..721 CDD:409353 2/9 (22%)
Ig strand G 729..732 CDD:409353 0/2 (0%)
Ig_3 740..820 CDD:464046 21/89 (24%)
IgC1_hNephrin_like 834..942 CDD:143250 6/15 (40%)
putative Ig strand A 839..844 CDD:143250 1/6 (17%)
putative Ig strand B 859..866 CDD:143250
putative Ig strand C 870..876 CDD:143250
putative Ig strand C' 879..881 CDD:143250
putative Ig strand D 888..891 CDD:143250
putative Ig strand E 898..906 CDD:143250
putative Ig strand F 917..924 CDD:143250
putative Ig strand G 939..942 CDD:143250
FN3 941..1022 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1025..1057
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1099..1137
Binds to NPHS2 1160..1241
Blue background indicates that the domain is not in the aligned region.

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