DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17716 and alcamb

DIOPT Version :9

Sequence 1:	NP_001286391.1	Gene:	CG17716 / 36521	FlyBaseID:	FBgn0000633	Length:	822	Species:	Drosophila melanogaster
Sequence 2:	NP_997799.3	Gene:	alcamb / 323919	ZFINID:	ZDB-GENE-030131-1768	Length:	562	Species:	Danio rerio

Alignment Length:	615	Identity:	134/615 - (21%)
Similarity:	226/615 - (36%)	Gaps:	158/615 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 MSVVYAEQHSEIKLMCE----VDLDIATSMWY--KNGQVV--HAMDRTARVTDYRF-----IKEA 294
            :..|..:....:::.|.    .|:.:....|.  |:|.::  |.....:..||..:     ||:.
Zfish    22 LETVTGKYGDTVEIPCNSGLVSDVGVTFVKWKSDKDGSILVKHTGQNASSPTDGNYKNRVSIKKD 86

  Fly   295 NGALTITNVMLEDDGKWQC---EAENTRRYTENARPVKLVVLDRPKPPYLLIDSRRLDASNLFVP 356
            .| |.||.|.|.|...:.|   .|::...|     ||:||:...|..|.:         :||...
Zfish    87 FG-LIITQVSLADQKTFTCMVVAADDILEY-----PVQLVIYKTPLQPQI---------ANLTTA 136

  Fly   357 VKENSELNLA-CVSEGGNPRPTLTWEVLLSPGV-DRHAQKVSAEVLELEEIKGEKLDK-DGYKIN 418
            ::......|| |.:||.||...:||....:|.: |..|.|::.:|         .:|| .|.
Zfish   137 MEIGKLTTLAQCHTEGANPAANITWFKNKTPLIADGTAIKITNDV---------AVDKATGL--- 189

  Fly   419 SGAKSEARLPAVYRAHHNARILCVMEHPTLKIRQNASLLLDVQYTPSFAISRTPGFGYPLREGIE 483
            |...|:....|| :...|::..|.::|.......::.|:..|.| ||..||.......|::||..
Zfish   190 SATTSKLEYTAV-KDDINSKFTCQVQHIKSANMDSSPLVFTVNY-PSETISFHVLPDGPVKEGDN 252

  Fly   484 VSLKCDVDSNPPSTPRWQKDDGDTPVPQTGDGFLNFTSIRREHSGWYKCT---------SRHLNF 539
            |:|||..|.|||.:.......|:....:..:.|: .:::.|:::|.|||:         |:::..
Zfish   253 VTLKCTADGNPPPSRYNFYIKGEKKTVEKSNIFI-LSNVTRQNTGEYKCSLVDNEILTASKNITV 316

  Fly   540 QY-----SSIGYYLSVRFDSVDVTSEPDDQDVSVAAASHNPNKGQLEVQLGGAVTLQCPQGSLGC 599
            :|     |:.|.......||.:.|                     |:::..|.....|.:|
Zfish   317 EYLDVILSTTGEVFKKLGDSFETT---------------------LDIKASGKTETFCKKG---- 356

  Fly   600 WSHLDPISARLRGLGYGSSQPTGQFSLKDVMYQDAGMYKCVGQSPTNKKKLEVLQSVTVSVKGAP 664
                          |.....|....|||   |.|:|:|:||    .....|:..|:..::|.|.|
Zfish   357 --------------GEKMVGPPKFASLK---YTDSGVYECV----VTMLGLKKTQTFDLNVHGQP 400

  Fly   665 TVMALNATPVAYPGSPLHLNVEFCANPPAHAARWLHGDRVFTPGNQYGTTVLAYAVKDLPTPFCK 729
            .:.:|  |.....|:...|:.| ....|....:|:..          ||.|....
Zfish   401 LIKSL--TKKRGDGTNKILSCE-AEGSPKPTVQWITN----------GTDVKFQE---------- 442

  Fly   730 EARLTYVSMHERVPRTFYFIVSTPGGVAEA--IFN-VNFTKRHRQLSNSIDD------DEEEELN 785
                   |.|.....|:|..||....|..:  |.| :....|...:|:.::|      |:.|:.:
Zfish   443 -------SEHVNGKITYYITVSPKANVTVSCTISNDLGSDTRSIDVSSLVEDVTMDKQDQSEDYS 500

  Fly   786 RPEQIHFPVFNGSPADGRGWWAVVLALLLV 815
            ....:...:..|          ::||.||:
Zfish   501 DQTALAVGIVVG----------LMLAALLI 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17716	NP_001286391.1	IG_like	244..332	CDD:214653	24/103 (23%)
		Ig	254..323	CDD:143165	20/84 (24%)
		Ig	359..452	CDD:299845	24/95 (25%)
		Ig_3	477..536	CDD:290638	19/67 (28%)
		IG_like	479..550	CDD:214653	21/84 (25%)
		IG_like	578..660	CDD:214653	17/81 (21%)
alcamb	NP_997799.3	Ig	23..121	CDD:299845	24/103 (23%)
		IG_like	23..121	CDD:214653	24/103 (23%)
		C2-set_2	128..215	CDD:285423	26/108 (24%)
		Ig_3	241..300	CDD:290638	16/59 (27%)
		IG_like	243..317	CDD:214653	19/74 (26%)
		IG_like	403..482	CDD:214653	20/108 (19%)
		Ig	411..473	CDD:299845	17/89 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	82	1.000	Inparanoid score	I5177
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.960