DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fand and Xab2

DIOPT Version :9

Sequence 1:	NP_610891.1	Gene:	fand / 36514	FlyBaseID:	FBgn0033859	Length:	883	Species:	Drosophila melanogaster
Sequence 2:	NP_080432.1	Gene:	Xab2 / 67439	MGIID:	1914689	Length:	855	Species:	Mus musculus

Alignment Length:	877	Identity:	539/877 - (61%)
Similarity:	683/877 - (77%)	Gaps:	30/877 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVTKTIKSLNLEINFEVEDVPYEEEILRNAYSVKHWLRYIDHKAKAPNNGVNMVYERALKELPGS 65
            ::.:..:|...::.||.||:||||||:||.:|||.|||||:.|..||...:|.:||||||.||.|
Mouse     3 VMARVPRSERPDLVFEEEDLPYEEEIMRNQFSVKCWLRYIEFKQGAPKPRLNQLYERALKLLPCS 67

  Fly    66 YKIWHNYLRTRRKQVRGKIPTDPMYEEVNSAFERALVFMHKMPRIWMDYGAFMTSQCKITRTRHV 130
            ||:|:.||:.||.||:.:..|||.||:||:..|||.||||||||:|:||..|:..|.::|.||..
Mouse    68 YKLWYRYLKARRAQVKHRCVTDPAYEDVNNCHERAFVFMHKMPRLWLDYCQFLMDQGRVTHTRRT 132

  Fly   131 FDRALRALPITQHGRIWPLYLQFVRRFEMPETALRVYRRYLKLFPEDTEEYVDYLQEADRLDEAA 195
            |||||||||||||.|||||||:|:|...:||||:|.|||:|||.||..|||::||:.:|||||||
Mouse   133 FDRALRALPITQHSRIWPLYLRFLRSHPLPETAVRGYRRFLKLSPESAEEYIEYLKSSDRLDEAA 197

  Fly   196 QQLAHIVDNEHFVSKHGKSNHQLWNELCDLISKNPHKVHSLNVDAIIRGGLRRYTDQLGHLWNSL 260
            |:||.:|::|.||||.||||:|||:|||||||:||.||.||||||||||||.|:|||||.||.||
Mouse   198 QRLATVVNDERFVSKAGKSNYQLWHELCDLISQNPDKVQSLNVDAIIRGGLTRFTDQLGKLWCSL 262

  Fly   261 ADYYVRSGLFDRARDIYEEAIQTVTTVRDFTQVFDEYAQFEELSLNRRMEQVAANEAATEEDDID 325
            ||||:|||.|::|||:|||||:||.||||||||||.||||||..:..:|| .|:.....||||:|
Mouse   263 ADYYIRSGHFEKARDVYEEAIRTVMTVRDFTQVFDSYAQFEESMIAAKME-TASELGREEEDDVD 326

  Fly   326 VELRLSRFEYLMERRLLLLNSVLLRQNPHNVHEWHKRVTLYEDKPAEIISTYTEAVQTVQPKQAV 390
            :||||:|||.|:.||.|||||||||||||:||||||||.|::.:|.|||:|||||||||.|.:|.
Mouse   327 LELRLARFEQLISRRPLLLNSVLLRQNPHHVHEWHKRVALHQGRPREIINTYTEAVQTVDPFKAT 391

  Fly   391 GKLHTLWVEFAKFYEANGQVEDARVVFERGTEVEYVKVEDLAAVWCEWAEMELRQQQFEAALKLM 455
            ||.|||||.||||||.|||::||||:.|:.|:|.:.:|:|||:|||:..|:|||.:.::.||||:
Mouse   392 GKPHTLWVAFAKFYEDNGQLDDARVILEKATKVNFKQVDDLASVWCQCGELELRHENYDEALKLL 456

  Fly   456 QRATAMPKRKIAYYDDTETVQARLHRSLKVWSMYADLEESFGTFKTCKAVYERIIDLKICTPQII 520
            ::|||:|.|:..|:|.:|.||.|:::|||||||.||||||.|||::.||||:||:||:|.||||:
Mouse   457 RKATALPARRAEYFDGSEPVQNRVYKSLKVWSMLADLEESLGTFQSTKAVYDRILDLRIATPQIV 521

  Fly   521 INYGMFLEEHNYFEEAYRAYEKGISLFKWPNVYDIWNSYLTKFLERYGGTKLERARDLFEQCLDQ 585
            |||.||||||.||||:::|||:||||||||||.|||::|||||:.||||.|||||||||||.||.
Mouse   522 INYAMFLEEHKYFEESFKAYERGISLFKWPNVSDIWSTYLTKFISRYGGRKLERARDLFEQALDG 586

  Fly   586 CPPEHAKYFYLLYAKLEEEHGLARHAMSVYDRATSAVKEDEMFDMYNIFIKKAAEIYGLPRTREI 650
            |||::||..|||||:||||.|||||||:||||||.||:..:.:||:||:||:||||||:..||.|
Mouse   587 CPPKYAKTLYLLYAQLEEEWGLARHAMAVYDRATRAVEPAQQYDMFNIYIKRAAEIYGVTHTRGI 651

  Fly   651 YEKAIESLPEQNMRHMCVKFAELETKLGEVDRARAIYAHCSQVCDPRITADFWQTWKEFEVRHGN 715
            |:||||.|.:::.|.||::||::|.||||:|||||||:.|||:||||.|..||||||:|||||||
Mouse   652 YQKAIEVLSDEHAREMCLRFADMECKLGEIDRARAIYSFCSQICDPRTTGAFWQTWKDFEVRHGN 716

  Fly   716 EDTMREMLRIKRSVQATYNTQVNMMAAQFLSTN---NGAAADAGAG-AGPDAMRLLEEKARQAAA 776
            |||:||||||:||||||||||||.||:|.|..:   .|..:|...| :|.|.|:|||::|.|.||
Mouse   717 EDTIREMLRIRRSVQATYNTQVNFMASQMLKVSGSATGTVSDLAPGQSGMDDMKLLEQRAEQLAA 781

  Fly   777 ESKQKPIEKAASNIMFVRGETQGGAKDKKDTVVNPDEIDIGDSDEDDEEEDDDEENEMTNENQAS 841
            |:::....:|.|.|.|||.:.......:.....||:||.:|  :::||:|.|.|.||
Mouse   782 EAERDQPPRAQSKIFFVRSDASREELAELAQQANPEEIQLG--EDEDEDEMDLEPNE-------- 836

  Fly   842 AAVTKTDEEGLVMKKLRFEQKAIPAKVFGSLK 873
                           :|.||:::||.||||||
Mouse   837 ---------------VRLEQQSVPAAVFGSLK 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fand	NP_610891.1	TPR repeat	432..460	CDD:276809	13/27 (48%)
		PilF	443..>617	CDD:225605	120/173 (69%)
		TPR repeat	482..512	CDD:276809	22/29 (76%)
		TPR repeat	517..545	CDD:276809	20/27 (74%)
		TPR repeat	553..584	CDD:276809	23/30 (77%)
		TPR repeat	591..618	CDD:276809	21/26 (81%)
Xab2	NP_080432.1	HAT 1. /evidence=ECO:0000305	15..47		21/31 (68%)
		HAT 2. /evidence=ECO:0000305	48..80		18/31 (58%)
		HAT 3. /evidence=ECO:0000305	90..122		20/31 (65%)
		HAT 4. /evidence=ECO:0000305	124..158		24/33 (73%)
		HAT 5. /evidence=ECO:0000305	160..192		18/31 (58%)
		HAT 6	198..230		22/31 (71%)
		HAT 7	235..268		27/32 (84%)
		HAT 8	270..305		27/34 (79%)
		TPR	272..549	CDD:223533	180/277 (65%)
		HAT 9	369..407		27/37 (73%)
		TPR repeat	389..424	CDD:276809	23/34 (68%)
		TPR repeat	433..459	CDD:276809	12/25 (48%)
		TPR repeat	466..513	CDD:276809	28/46 (61%)
		type_IV_pilW	<486..618	CDD:131573	100/131 (76%)
		HAT 10	498..530		22/31 (71%)
		TPR repeat	518..546	CDD:276809	20/27 (74%)
		HAT 11	532..566		25/33 (76%)
		HAT 12	571..605		25/33 (76%)
		HAT 13	643..677		17/33 (52%)
		HAT 14	679..713		25/33 (76%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	808..855		23/71 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850433
Domainoid	1	1.000	531	1.000	Domainoid score	I286
eggNOG	1	0.900	-	-		E1_KOG2047
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5738
Inparanoid	1	1.050	1098	1.000	Inparanoid score	I235
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53990
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005117
OrthoInspector	1	1.000	-	-		oto92615
orthoMCL	1	0.900	-	-		OOG6_102092
Panther	1	1.100	-	-	LDO	PTHR11246
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1435
SonicParanoid	1	1.000	-	-		X4146
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790