DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fand and XAB2

DIOPT Version :9

Sequence 1:	NP_610891.1	Gene:	fand / 36514	FlyBaseID:	FBgn0033859	Length:	883	Species:	Drosophila melanogaster
Sequence 2:	NP_064581.2	Gene:	XAB2 / 56949	HGNCID:	14089	Length:	855	Species:	Homo sapiens

Alignment Length:	866	Identity:	536/866 - (61%)
Similarity:	680/866 - (78%)	Gaps:	30/866 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 EINFEVEDVPYEEEILRNAYSVKHWLRYIDHKAKAPNNGVNMVYERALKELPGSYKIWHNYLRTR 76
            ::.||.||:||||||:||.:|||.|||||:.|..||...:|.:||||||.||.|||:|:.||:.|
Human    14 DLVFEEEDLPYEEEIMRNQFSVKCWLRYIEFKQGAPKPRLNQLYERALKLLPCSYKLWYRYLKAR 78

  Fly    77 RKQVRGKIPTDPMYEEVNSAFERALVFMHKMPRIWMDYGAFMTSQCKITRTRHVFDRALRALPIT 141
            |.||:.:..|||.||:||:..|||.||||||||:|:||..|:..|.::|.||..|||||||||||
Human    79 RAQVKHRCVTDPAYEDVNNCHERAFVFMHKMPRLWLDYCQFLMDQGRVTHTRRTFDRALRALPIT 143

  Fly   142 QHGRIWPLYLQFVRRFEMPETALRVYRRYLKLFPEDTEEYVDYLQEADRLDEAAQQLAHIVDNEH 206
            ||.|||||||:|:|...:||||:|.|||:|||.||..|||::||:.:||||||||:||.:|::|.
Human   144 QHSRIWPLYLRFLRSHPLPETAVRGYRRFLKLSPESAEEYIEYLKSSDRLDEAAQRLATVVNDER 208

  Fly   207 FVSKHGKSNHQLWNELCDLISKNPHKVHSLNVDAIIRGGLRRYTDQLGHLWNSLADYYVRSGLFD 271
            ||||.||||:|||:|||||||:||.||.||||||||||||.|:|||||.||.||||||:|||.|:
Human   209 FVSKAGKSNYQLWHELCDLISQNPDKVQSLNVDAIIRGGLTRFTDQLGKLWCSLADYYIRSGHFE 273

  Fly   272 RARDIYEEAIQTVTTVRDFTQVFDEYAQFEELSLNRRMEQVAANEAATEEDDIDVELRLSRFEYL 336
            :|||:|||||:||.||||||||||.||||||..:..:|| .|:.....||||:|:||||:|||.|
Human   274 KARDVYEEAIRTVMTVRDFTQVFDSYAQFEESMIAAKME-TASELGREEEDDVDLELRLARFEQL 337

  Fly   337 MERRLLLLNSVLLRQNPHNVHEWHKRVTLYEDKPAEIISTYTEAVQTVQPKQAVGKLHTLWVEFA 401
            :.||.|||||||||||||:||||||||.|::.:|.|||:|||||||||.|.:|.||.|||||.||
Human   338 ISRRPLLLNSVLLRQNPHHVHEWHKRVALHQGRPREIINTYTEAVQTVDPFKATGKPHTLWVAFA 402

  Fly   402 KFYEANGQVEDARVVFERGTEVEYVKVEDLAAVWCEWAEMELRQQQFEAALKLMQRATAMPKRKI 466
            ||||.|||::||||:.|:.|:|.:.:|:|||:|||:..|:|||.:.::.||:|:::|||:|.|:.
Human   403 KFYEDNGQLDDARVILEKATKVNFKQVDDLASVWCQCGELELRHENYDEALRLLRKATALPARRA 467

  Fly   467 AYYDDTETVQARLHRSLKVWSMYADLEESFGTFKTCKAVYERIIDLKICTPQIIINYGMFLEEHN 531
            .|:|.:|.||.|:::|||||||.||||||.|||::.||||:||:||:|.||||:|||.||||||.
Human   468 EYFDGSEPVQNRVYKSLKVWSMLADLEESLGTFQSTKAVYDRILDLRIATPQIVINYAMFLEEHK 532

  Fly   532 YFEEAYRAYEKGISLFKWPNVYDIWNSYLTKFLERYGGTKLERARDLFEQCLDQCPPEHAKYFYL 596
            ||||:::|||:||||||||||.|||::|||||:.||||.|||||||||||.||.|||::||..||
Human   533 YFEESFKAYERGISLFKWPNVSDIWSTYLTKFIARYGGRKLERARDLFEQALDGCPPKYAKTLYL 597

  Fly   597 LYAKLEEEHGLARHAMSVYDRATSAVKEDEMFDMYNIFIKKAAEIYGLPRTREIYEKAIESLPEQ 661
            |||:||||.|||||||:||:|||.||:..:.:||:||:||:||||||:..||.||:||||.|.::
Human   598 LYAQLEEEWGLARHAMAVYERATRAVEPAQQYDMFNIYIKRAAEIYGVTHTRGIYQKAIEVLSDE 662

  Fly   662 NMRHMCVKFAELETKLGEVDRARAIYAHCSQVCDPRITADFWQTWKEFEVRHGNEDTMREMLRIK 726
            :.|.||::||::|.||||:|||||||:.|||:||||.|..||||||:||||||||||::|||||:
Human   663 HAREMCLRFADMECKLGEIDRARAIYSFCSQICDPRTTGAFWQTWKDFEVRHGNEDTIKEMLRIR 727

  Fly   727 RSVQATYNTQVNMMAAQFLSTN---NGAAADAGAG-AGPDAMRLLEEKARQAAAESKQKPIEKAA 787
            ||||||||||||.||:|.|..:   .|..:|...| :|.|.|:|||::|.|.|||:::....:|.
Human   728 RSVQATYNTQVNFMASQMLKVSGSATGTVSDLAPGQSGMDDMKLLEQRAEQLAAEAERDQPLRAQ 792

  Fly   788 SNIMFVRGETQGGAKDKKDTVVNPDEIDIGDSDEDDEEEDDDEENEMTNENQASAAVTKTDEEGL 852
            |.|:|||.:.......:....|||:||.:|  :::||:|.|.|.||
Human   793 SKILFVRSDASREELAELAQQVNPEEIQLG--EDEDEDEMDLEPNE------------------- 836

  Fly   853 VMKKLRFEQKAIPAKVFGSLK 873
                :|.||:::||.||||||
Human   837 ----VRLEQQSVPAAVFGSLK 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fand	NP_610891.1	TPR repeat	432..460	CDD:276809	12/27 (44%)
		PilF	443..>617	CDD:225605	119/173 (69%)
		TPR repeat	482..512	CDD:276809	22/29 (76%)
		TPR repeat	517..545	CDD:276809	20/27 (74%)
		TPR repeat	553..584	CDD:276809	23/30 (77%)
		TPR repeat	591..618	CDD:276809	20/26 (77%)
XAB2	NP_064581.2	HAT 1. /evidence=ECO:0000305	15..47		21/31 (68%)
		HAT 2. /evidence=ECO:0000305	48..80		18/31 (58%)
		HAT 3. /evidence=ECO:0000305	90..122		20/31 (65%)
		HAT 4. /evidence=ECO:0000305	124..158		24/33 (73%)
		HAT 5. /evidence=ECO:0000305	160..192		18/31 (58%)
		HAT 6	198..230		22/31 (71%)
		HAT 7	235..268		27/32 (84%)
		HAT 8	270..305		27/34 (79%)
		TPR	272..549	CDD:223533	179/277 (65%)
		HAT 9	369..407		27/37 (73%)
		TPR repeat	389..424	CDD:276809	23/34 (68%)
		TPR_12	396..462	CDD:315987	36/65 (55%)
		TPR repeat	433..459	CDD:276809	11/25 (44%)
		TPR repeat	466..513	CDD:276809	28/46 (61%)
		HAT 10	498..530		22/31 (71%)
		TPR repeat	518..546	CDD:276809	20/27 (74%)
		HAT 11	532..566		25/33 (76%)
		HAT 12	571..605		25/33 (76%)
		HAT 13	643..677		17/33 (52%)
		HAT 14	679..713		25/33 (76%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	810..855		24/69 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160063
Domainoid	1	1.000	528	1.000	Domainoid score	I287
eggNOG	1	0.900	-	-		E1_KOG2047
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5738
Inparanoid	1	1.050	1098	1.000	Inparanoid score	I237
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53990
OrthoDB	1	1.010	-	-		D155702at33208
OrthoFinder	1	1.000	-	-		FOG0005117
OrthoInspector	1	1.000	-	-		oto89049
orthoMCL	1	0.900	-	-		OOG6_102092
Panther	1	1.100	-	-	LDO	PTHR11246
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1435
SonicParanoid	1	1.000	-	-		X4146
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800