DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment fand and Heatr6

DIOPT Version :9

Sequence 1:NP_610891.1 Gene:fand / 36514 FlyBaseID:FBgn0033859 Length:883 Species:Drosophila melanogaster
Sequence 2:NP_001073366.1 Gene:Heatr6 / 497972 RGDID:1566204 Length:1252 Species:Rattus norvegicus


Alignment Length:542 Identity:100/542 - (18%)
Similarity:172/542 - (31%) Gaps:183/542 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   302 ELSL--NRRMEQVAANEAATEEDDIDV---ELRLSRFEYLMERR-------------LLLLNS-- 346
            ||||  |....:::|...|.:.||..|   |:.| .|:.|:...             .||:.:  
  Rat    92 ELSLEQNNGFRRLSARLRALQPDDSTVSRMEIHL-LFDQLISENYCEGGGVAPEDVSALLVRACQ 155

  Fly   347 -VLLRQN------PHNVHEWHKRV-TLYEDKPAEIISTYT-EAVQTVQPKQAVGKLHTLWVEFAK 402
             |.|.||      ...:|....|: .:.:::..:.:.||| .|:|...|          |     
  Rat   156 LVPLNQNHLVSKVSQLIHRLLNRLQVIVDEQNLDFLLTYTISAIQQCSP----------W----- 205

  Fly   403 FYEANGQVEDARVVFERGTEVEYVKVEDLAA-VWCEWAEMELRQQQFEAALKLMQRATAMPKRKI 466
                              |.:|.::.  ||| |:|..::.:.....      |:.::..:.|...
  Rat   206 ------------------THMEILQA--LAALVYCNGSKCQKHLPD------LLGKSGLLMKLSD 244

  Fly   467 AYYDDTETVQARLHRSLKVWSMYADLEESFGTFKTCKAVYERIIDLKICTPQIIINYGMFLEEHN 531
            ..:.|.|..:|.:|                     |.|                 |..:.:....
  Rat   245 VTHSDPEVRRAAVH---------------------CMA-----------------NLCLSVPGQP 271

  Fly   532 YFEEAYR--AYEKGISLFKWPNVYDIWNSYLTKFLERYGGTKLERARDLFEQCLDQCPPEHAKYF 594
            |.||:|:  .::..:::.:.|...|:.:......|:    ..|:..:.|.               
  Rat   272 YLEESYQLVCFQAFLTILQSPKSSDMDDITFCMLLQ----NALKGIQSLL--------------- 317

  Fly   595 YLLYAKLEEEHGLARHAMSVYDRATSAVKEDEMF-DMYNIFIKKAAEIYGLPRTREIYEKAIESL 658
                     ..|..|...:.:..|..||.:..|| .:..:.|:..|.:|..|..:  |:......
  Rat   318 ---------NGGKMRLTQTEHLGALLAVLKKAMFHGLPGLNIEMPAVLYPTPLPQ--YDGRSPVK 371

  Fly   659 PEQ-----------NMRHMCVK--------FAELETKLGEVDRARAIYAHCSQVCDPRITADFW- 703
            |:|           ..:...||        .||.|...||||.|..:....:..|    ....| 
  Rat   372 PQQPESSAARPSANKKKKYKVKPKKTQQGEKAEEEEPYGEVDAAPGLSMDQANTC----VESAWC 432

  Fly   704 -QTWKEFEVR-HGNEDTMREMLRIKRSVQATYNTQVNMMAAQFLSTNNGAAADAGAGAGPDAMRL 766
             ..|....:. .|...|.||.:          ::...:.:.:.:|::....:||..|. ...||.
  Rat   433 SSPWGSQGLPVDGGRATGREQV----------SSPFTISSWKRVSSSESDYSDAEGGM-QGKMRS 486

  Fly   767 LEEKARQAAAE---SKQKPIEK 785
            .:.|.||.|..   |..|.|||
  Rat   487 YQAKVRQGALACFLSTIKSIEK 508

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fandNP_610891.1 TPR repeat 432..460 CDD:276809 5/28 (18%)
PilF 443..>617 CDD:225605 20/175 (11%)
TPR repeat 482..512 CDD:276809 2/29 (7%)
TPR repeat 517..545 CDD:276809 5/29 (17%)
TPR repeat 553..584 CDD:276809 4/30 (13%)
TPR repeat 591..618 CDD:276809 2/26 (8%)
Heatr6NP_001073366.1 HEAT 1 230..269 9/82 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 365..417 12/51 (24%)
DUF4042 490..671 CDD:289992 9/19 (47%)
HEAT 2 524..562
HEAT 3 586..624
HEAT 4 630..667
HEAT repeat 885..914 CDD:293787
HEAT repeat 928..957 CDD:293787
HEAT repeat 980..1005 CDD:293787
HEAT repeat 1028..1054 CDD:293787
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2047
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.