DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fand and CG6841

DIOPT Version :9

Sequence 1:	NP_610891.1	Gene:	fand / 36514	FlyBaseID:	FBgn0033859	Length:	883	Species:	Drosophila melanogaster
Sequence 2:	NP_001303371.1	Gene:	CG6841 / 40064	FlyBaseID:	FBgn0036828	Length:	931	Species:	Drosophila melanogaster

Alignment Length:	656	Identity:	129/656 - (19%)
Similarity:	235/656 - (35%)	Gaps:	154/656 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 LYLQFVRRFEMPETALRVYRRYLKLFPEDTEEYVDYLQEADRLDEA-------AQQLAHIVDNEH 206
            |:|: ..|.:.|:||..|..:..:..|.....::   :.||...|.       .:.|.||
  Fly   335 LWLE-AARLQPPDTAKAVIAQAARHIPTSVRIWI---KAADLESETKAKRRVFRKALEHI----- 390

  Fly   207 FVSKHGKSNHQLWNELCDLISKNPHKVHSLNVDAIIRGGLRRYTDQLGHLWNSLADYYVRSGLFD 271
                  .::.:||....:|  :||.....|...|:      ...:....||.:||    |...::
  Fly   391 ------PNSVRLWKAAVEL--ENPDDARILLSRAV------ECCNTSVELWLALA----RLETYE 437

  Fly   272 RARDIYEEAIQTVTTVRDFTQVFDEYAQFEELSLNRRMEQVAANEAATEEDDIDVELRLSRFEYL 336
            .||.:..:|.:.:.|.|   |::...|:.||.:.|..|                       .|.:
  Fly   438 NARKVLNKARENIPTDR---QIWTTAAKLEEANGNIHM-----------------------VEKI 476

  Fly   337 MERRL--LLLNSVLLRQNPHNVHEWHKRVTLYEDKPA-EIISTYTEAVQTVQPKQAVGKLHTLWV 398
            ::|.|  |.:|.|.:     |..:|.:.....|...| ....:..:||..:..::...|  ..|:
  Fly   477 IDRSLTSLTVNGVEI-----NRDQWFQEAIEAEKSGAVNCCQSIVKAVIGIGVEEEDRK--QTWI 534

  Fly   399 EFAKFYEANGQVEDARVVFERGTEVEYVKVEDLAAVWCEWAEMELRQQQFEAALKLMQRATA-MP 462
            :.|:|.......|.||.|:....::...|    .::|...|..|......|:...|:|||.| .|
  Fly   535 DDAEFCAKENAFECARAVYAHALQIFPSK----KSIWLRAAYFEKNHGTRESLEALLQRAVAHCP 595

  Fly   463 KRKIAYY---------DDTETVQARLH-------RSLKVWSMYADLEESFGTFKTCKAVYERIID 511
            |.:|.:.         .|....:..|.       .|..:|.....||..       .:.|||...
  Fly   596 KSEILWLMGAKSKWMAGDVPAARGILSLAFQANPNSEDIWLAAVKLESE-------NSEYERARR 653

  Fly   512 L------KICTPQIIINYGMFLEEHNYFEEAYRAYEKGISLFKWPNVYDIWNSYLTKFLERYGGT 570
            |      ...||::::...........|:||.|..|:.:.:|  |:...:|   :.|........
  Fly   654 LLAKARGSAPTPRVMMKSARLEWALEKFDEALRLLEEAVEVF--PDFPKLW---MMKGQIEEQQR 713

  Fly   571 KLERARDLFEQCLDQCPPEHAKYFYLLYAKLEEEHGLARHAMSVYDRA-----------TSAVKE 624
            :.:.|...:...|.:||....  .::|.|.|||..|:...|.|:.:|.           ..|::.
  Fly   714 RTDDAAATYTLGLKKCPTSIP--LWILSANLEERKGVLTKARSILERGRLRNPKVAVLWLEAIRV 776

  Fly   625 DEMFDMYNI-FIKKAAEIYGLPRTREIYEKAI--ESLPEQNMR------------HMCVKFAELE 674
            :....:..| ....|..:...|...|::.:||  |:.|::..:            |:.:..::|.
  Fly   777 ELRAGLKEIASTMMARALQECPNAGELWAEAIFMETKPQRKTKSVDALKKCEHDPHVLLAVSKLF 841

  Fly   675 TKLGEVDRARAIYAHCSQVCDPRITADFWQTWKEFEVRHGNEDTMREML---------------R 724
            ....:..:.|..:....:: ||.: .|.|..:.:||:.||.|...:|:|               |
  Fly   842 WSEHKFSKCRDWFNRTVKI-DPDL-GDAWAYFYKFELLHGTEAQQQEVLDRCISAEPTHGESWCR 904

  Fly   725 IKRSVQ 730
            :.:::|
  Fly   905 VSKNIQ 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fand	NP_610891.1	TPR repeat	432..460	CDD:276809	8/27 (30%)
		PilF	443..>617	CDD:225605	42/196 (21%)
		TPR repeat	482..512	CDD:276809	7/29 (24%)
		TPR repeat	517..545	CDD:276809	6/27 (22%)
		TPR repeat	553..584	CDD:276809	3/30 (10%)
		TPR repeat	591..618	CDD:276809	8/26 (31%)
CG6841	NP_001303371.1	PRP1_N	22..173	CDD:283962
		TPR repeat	393..419	CDD:276809	7/33 (21%)
		TPR repeat	424..448	CDD:276809	8/27 (30%)
		HAT	434..466	CDD:214642	8/34 (24%)
		TPR repeat	454..481	CDD:276809	9/52 (17%)
		TPR	543..803	CDD:223533	55/277 (20%)
		HAT	546..576	CDD:214642	8/33 (24%)
		TPR repeat	633..660	CDD:276809	7/33 (21%)
		TPR_14	665..708	CDD:290164	10/47 (21%)
		TPR repeat	698..728	CDD:276809	4/32 (13%)
		TPR repeat	733..758	CDD:276809	8/26 (31%)
		TPR repeat	767..795	CDD:276809	3/27 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446190
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11246
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940