DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fand and cwf3

DIOPT Version :9

Sequence 1:	NP_610891.1	Gene:	fand / 36514	FlyBaseID:	FBgn0033859	Length:	883	Species:	Drosophila melanogaster
Sequence 2:	NP_596612.1	Gene:	cwf3 / 2540753	PomBaseID:	SPBC211.02c	Length:	790	Species:	Schizosaccharomyces pombe

Alignment Length:	792	Identity:	340/792 - (42%)
Similarity:	506/792 - (63%)	Gaps:	35/792 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LEINFE---VEDVPYEEEILRNAYSVKHWLRYI-DHKAKAPNNGVNMVYERALKELPGSYKIWHN 71
            |::||:   |:|.|:|.|:||:.||:|.||||| .|:.......| :::|||..|||||||||.:
pombe     7 LKVNFDLINVDDEPFELELLRDPYSLKSWLRYIKTHEGSTLEKRV-LLFERACSELPGSYKIWKS 70

  Fly    72 YLRTRRKQVRGKIP--TDPMYEEVNSAFERALVFMHKMPRIWMDYGAFMTSQCKITRTRHVFDRA 134
            ||..|...|....|  ....:..||..|||:|:.:||||.||..|..|:..|..:|:.|..|:.|
pombe    71 YLELRVAHVEHLNPYFHAEAFASVNDCFERSLILLHKMPVIWKLYLQFLMKQPNVTKIRCTFNSA 135

  Fly   135 LRALPITQHGRIWPLYLQFVR----RFEMPETALRVYRRYLKLFPEDTEEYVDYLQEADRLDEAA 195
            |||||:|||..||.::.::..    .|     .:.|||||:::.|...|.|::.|.:....:|||
pombe   136 LRALPVTQHDDIWDMFTKYAEDIGGLF-----CIHVYRRYIQVEPRAIENYIEILCKLGLWNEAA 195

  Fly   196 QQLAHIVDNEHFVSKHGKSNHQLWNELCDLISKNPHKVHSLNVDAIIRGGLRRYTDQLGHLWNSL 260
            :|...|::...|:|...|||:|:|.|..:|:.::|....:::|:.:.|.|::|::||.|.||..|
pombe   196 RQYEDILNRPVFLSAKRKSNYQIWLEFSELVVQHPDHTQNIDVEKVFRAGIKRFSDQAGKLWTYL 260

  Fly   261 ADYYVRSGLFDRARDIYEEAIQTVTTVRDFTQVFDEYAQFEELSLNRRMEQVAANEAATEEDDID 325
            |.||:|.|.:::||..:.|.:..:.|||:||.:||.:.:|||..|:.|:|..:.|    ..|::.
pombe   261 AQYYIRIGDYEKARSTFYEGMNNIMTVRNFTIIFDAFVEFEEQWLSARVEASSGN----ANDELS 321

  Fly   326 VELRLSRFEYLMERRLLLLNSVLLRQNPHNVHEWHKRVTLYEDKPAEIISTYTEAVQTVQPKQAV 390
            ::..::..|.::::|.|.:|.||||||.:||.||.:||...||...:::..||:|::.|.||.|.
pombe   322 IDFHMAWLEKILDKRPLYINDVLLRQNINNVDEWLRRVKFLEDDSEKVVQVYTDAIKNVNPKLAH 386

  Fly   391 GKLHTLWVEFAKFYEANGQVEDARVVFERGTEVEYVKVEDLAAVWCEWAEMELRQQQFEAALKLM 455
            |.|..|:.|||:|||....:|.:|::||:.|.|.|..|.:||.||.:|||||||.|.|:||.||:
pombe   387 GSLGKLFSEFARFYENFDDLEQSRIIFEKATHVPYKTVNELAQVWIDWAEMELRHQNFDAARKLI 451

  Fly   456 QRATAMPKRK-IAYYDDTETVQARLHRSLKVWSMYADLEESFGTFKTCKAVYERIIDLKICTPQI 519
            ..|...|::. |:::|::.:.|.|||:|.|:|..|.|||||.||.:|.:.:|:|:.:|||.|||:
pombe   452 GDAVHAPRKSHISFFDESLSPQVRLHKSSKIWMYYLDLEESVGTIETTRKLYDRVFELKIATPQV 516

  Fly   520 IINYGMFLEEHNYFEEAYRAYEKGISLFKWPNVYDIWNSYLTKFLERYGGTKLERARDLFEQCLD 584
            ::||...|||:.|||::::.||:|::||.:|..:::||.|||||::||.||.:||.||||||.|:
pombe   517 VVNYANLLEENAYFEDSFKIYERGVALFSYPVAFELWNLYLTKFVKRYQGTHMERTRDLFEQALE 581

  Fly   585 QCPPEHAKYFYLLYAKLEEEHGLARHAMSVYDRATSAVKEDEMFDMYNIFIKKAAEIYGLPRTRE 649
            .||||.:|..|||||..||:.|.|:.::|:.::|...||..:...:||:.:.|.|..||:..||.
pombe   582 GCPPEFSKSIYLLYADFEEKFGKAKRSISILEKAADKVKTADRLAIYNVLLVKVALNYGVLATRT 646

  Fly   650 IYEKAIESLPEQNMRHMCVKFAELETKLGEVDRARAIYAHCSQVCDPRITADFWQTWKEFEVRHG 714
            :||||||||.:..::.||::|||:||||||:||||.||.|.||.||||:..|:|:.|:|||:|:|
pombe   647 VYEKAIESLSDSEVKDMCLRFAEMETKLGEIDRARLIYIHGSQYCDPRVETDYWKAWQEFEIRYG 711

  Fly   715 N-EDTMREMLRIKRSVQATYNTQVNMMAAQFLSTNNGAAADAGAGAGPDAMRLLE------EKAR 772
            | |:|::||||||||||..::|....:|.:       ||....|.|..|.|..||      .||.
pombe   712 NPEETVKEMLRIKRSVQTKFSTDSLHIAKR-------AAKIESAAAPMDPMEQLEMEKSEGPKAL 769

  Fly   773 QAAAESKQKPIE 784
            .....||..|.|
pombe   770 AGFVLSKSNPQE 781

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fand	NP_610891.1	TPR repeat	432..460	CDD:276809	17/27 (63%)
		PilF	443..>617	CDD:225605	85/174 (49%)
		TPR repeat	482..512	CDD:276809	14/29 (48%)
		TPR repeat	517..545	CDD:276809	13/27 (48%)
		TPR repeat	553..584	CDD:276809	19/30 (63%)
		TPR repeat	591..618	CDD:276809	11/26 (42%)
cwf3	NP_596612.1	RNA14	29..466	CDD:227438	176/446 (39%)
cwf3	NP_596612.1	Suf	534..>603	CDD:283497	38/68 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	441	1.000	Domainoid score	I76
eggNOG	1	0.900	-	-		E1_KOG2047
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5738
Inparanoid	1	1.050	663	1.000	Inparanoid score	I119
OMA	1	1.010	-	-		QHG53990
OrthoFinder	1	1.000	-	-		FOG0005117
OrthoInspector	1	1.000	-	-		oto100791
orthoMCL	1	0.900	-	-		OOG6_102092
Panther	1	1.100	-	-	LDO	PTHR11246
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1435
SonicParanoid	1	1.000	-	-		X4146
TreeFam	1	0.960	-	-
	14	13.860