DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fand and xab2

DIOPT Version :9

Sequence 1:	NP_610891.1	Gene:	fand / 36514	FlyBaseID:	FBgn0033859	Length:	883	Species:	Drosophila melanogaster
Sequence 2:	NP_001135604.1	Gene:	xab2 / 100216162	XenbaseID:	XB-GENE-1009276	Length:	839	Species:	Xenopus tropicalis

Alignment Length:	858	Identity:	525/858 - (61%)
Similarity:	666/858 - (77%)	Gaps:	31/858 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 EVEDVPYEEEILRNAYSVKHWLRYIDHKAKAPNNGVNMVYERALKELPGSYKIWHNYLRTRRKQV 80
            |.:|:.||||||.|.||||.|:||:::|...|:..:|:||||||||||||||:|:.||:.||:||
Frog     9 EEDDLQYEEEILCNPYSVKCWMRYLENKLSGPSQALNLVYERALKELPGSYKLWYAYLKQRRRQV 73

  Fly    81 RGKIPTDPMYEEVNSAFERALVFMHKMPRIWMDYGAFMTSQCKITRTRHVFDRALRALPITQHGR 145
            :.:..|||.:||||:..||||||||||||||:||..|:..||||||||..|||||||||||||.|
Frog    74 KRRCVTDPAFEEVNNCHERALVFMHKMPRIWLDYCQFLMDQCKITRTRRTFDRALRALPITQHHR 138

  Fly   146 IWPLYLQFVRRFEMPETALRVYRRYLKLFPEDTEEYVDYLQEADRLDEAAQQLAHIVDNEHFVSK 210
            ||||||:|||...:||||:|||||||||.||:.|||::||:..|||||||.:||.||:.:.||||
Frog   139 IWPLYLRFVRAHPLPETAVRVYRRYLKLSPENAEEYIEYLRSIDRLDEAASRLATIVNQDGFVSK 203

  Fly   211 HGKSNHQLWNELCDLISKNPHKVHSLNVDAIIRGGLRRYTDQLGHLWNSLADYYVRSGLFDRARD 275
            .||||:|||.|||.|:|::|..|.||:..|||||||.|:|||.|.||.:||:|:.|||.|::|||
Frog   204 EGKSNYQLWQELCTLLSQHPGSVRSLDAAAIIRGGLTRFTDQRGKLWCALAEYHTRSGHFEKARD 268

  Fly   276 IYEEAIQTVTTVRDFTQVFDEYAQFEELSLNRRMEQVAANEAATEEDDIDVELRLSRFEYLMERR 340
            :|||:|||||||||||||||.||||||..:..:||.| ::....::||:|:||||:|||.|:|||
Frog   269 VYEESIQTVTTVRDFTQVFDSYAQFEESVIAAKMETV-SDLGKEDDDDLDLELRLARFEQLIERR 332

  Fly   341 LLLLNSVLLRQNPHNVHEWHKRVTLYEDKPAEIISTYTEAVQTVQPKQAVGKLHTLWVEFAKFYE 405
            .||||:|||||||||:|||||||.||:|||.|||:|||||||||.|.:|.||.|:|||.||||||
Frog   333 PLLLNAVLLRQNPHNIHEWHKRVQLYQDKPHEIINTYTEAVQTVNPAKATGKPHSLWVAFAKFYE 397

  Fly   406 ANGQVEDARVVFERGTEVEYVKVEDLAAVWCEWAEMELRQQQFEAALKLMQRATAMPKRKIAYYD 470
            .|||:||||.:.:|.|.|:|..|::||:|||::.|||||.:.:|.||.::::|||:|.||..|:|
Frog   398 DNGQIEDARAILQRATLVQYTHVDELASVWCQFGEMELRHENYEQALNILRKATAVPARKAEYFD 462

  Fly   471 DTETVQARLHRSLKVWSMYADLEESFGTFKTCKAVYERIIDLKICTPQIIINYGMFLEEHNYFEE 535
            .:|.||.||::||:||||.||||||.||||:.||||:|||||:|.||||||||.:||||||||||
Frog   463 SSEPVQNRLYKSLRVWSMLADLEESLGTFKSTKAVYDRIIDLRIATPQIIINYALFLEEHNYFEE 527

  Fly   536 AYRAYEKGISLFKWPNVYDIWNSYLTKFLERYGGTKLERARDLFEQCLDQCPPEHAKYFYLLYAK 600
            :::|||:||:||:||||||||::||:||:.||||.|||||||||||.||.||.:.||..:|||||
Frog   528 SFKAYERGIALFRWPNVYDIWSTYLSKFIARYGGKKLERARDLFEQSLDGCPRKFAKNIFLLYAK 592

  Fly   601 LEEEHGLARHAMSVYDRATSAVKEDEMFDMYNIFIKKAAEIYGLPRTREIYEKAIESLPEQNMRH 665
            ||||||||||||::|:|||.||:..|.::|:||:||:||||||:..||.|||:|||.|.::..|.
Frog   593 LEEEHGLARHAMALYERATQAVETGEQYEMFNIYIKRAAEIYGVTHTRSIYERAIELLTDEQSRE 657

  Fly   666 MCVKFAELETKLGEVDRARAIYAHCSQVCDPRITADFWQTWKEFEVRHGNEDTMREMLRIKRSVQ 730
            ||::||::|.||||:|||||||::|||:||||:||.|||||::||||||||||:|||||:|||||
Frog   658 MCLRFADMECKLGEIDRARAIYSYCSQMCDPRLTAGFWQTWRDFEVRHGNEDTLREMLRVKRSVQ 722

  Fly   731 ATYNTQVNMMAAQFLSTNNGAAADAGAGAGPDAMRLLEEKARQAAAES-KQKPIEKAASNIMFVR 794
            |.||||...:.:|.|....|.|:: |.....|.|:.||::|...|||: |.||..|  ..|:|||
Frog   723 AKYNTQGTFLVSQKLRAAEGGASE-GINEPADEMQALEQRAAVIAAEAEKDKPQMK--EKILFVR 784

  Fly   795 GETQGGAKDKKDTVVNPDEIDIGDSDEDDEEEDDDEENEMTNENQASAAVTKTDEEGLVMKKLRF 859
            .:.......:.....|||||:||:.||.:||.:.||                          ::.
Frog   785 SDASRSELAELTRQSNPDEINIGEDDESEEELEPDE--------------------------VQL 823

  Fly   860 EQKAIPAKVFGSL 872
            |||::||.||..:
Frog   824 EQKSVPASVFSGI 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fand	NP_610891.1	TPR repeat	432..460	CDD:276809	13/27 (48%)
		PilF	443..>617	CDD:225605	120/173 (69%)
		TPR repeat	482..512	CDD:276809	23/29 (79%)
		TPR repeat	517..545	CDD:276809	21/27 (78%)
		TPR repeat	553..584	CDD:276809	23/30 (77%)
		TPR repeat	591..618	CDD:276809	20/26 (77%)
xab2	NP_001135604.1	PilF	416..615	CDD:225605	134/198 (68%)
		TPR repeat	424..452	CDD:276809	13/27 (48%)
		TPR repeat	457..504	CDD:276809	31/46 (67%)
		TPR repeat	509..537	CDD:276809	21/27 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1076	1.000	Domainoid score	I26
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H5738
Inparanoid	1	1.050	1082	1.000	Inparanoid score	I245
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D155702at33208
OrthoFinder	1	1.000	-	-		FOG0005117
OrthoInspector	1	1.000	-	-		oto102912
Panther	1	1.100	-	-	LDO	PTHR11246
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4146
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160