Protein Alignment CG6191 and CABLES1

DIOPT Version :10

• Sequence 1: NP_001260958.1
• Gene: CG6191 / 36513
• FlyBaseID: FBgn0027581
• Length: 746
• Species: Drosophila melanogaster
• Sequence 2: NP_001094089.1
• Gene: CABLES1 / 91768
• HGNCID: 25097
• Length: 633
• Species: Homo sapiens
• Alignment Length: 743
• Identity: 223/743 - (30%)
• Similarity: 311/743 - (41%)
• Gaps: 205/743 - (27%)

  Fly    11 RRRLAAISFLSNISLDG--THRDTKFG-------ATFGSSLLCNQNKNPSSLGLGSGGFHPHYQQ 66
            |||.||:|||:||||||  ..:|.::|       |..|:...|......|.|.....|
Human    60 RRRQAALSFLTNISLDGRLPPQDAEWGGGEEGGAAKPGAGGACGARTRFSLLAAAERG------- 117

  Fly    67 HHHQRSHSATHHNHQKRHHTQQQQQQQQQQHTQQQQQQQQHQQQHQQQQQHQNG--ALCSPLLCS 129
                                                                 |  ||.:|...:
Human   118 -----------------------------------------------------GCIALAAPGTPA 129

  Fly   130 ADVHMGIDGGIGLGLGLEDCTTGASDGDGHFSETENMGQYLMNVLPAADHNRSSIVPAERRNIKR 194
            |          ||..|...|....|.              |..::|......|.  |...|....
Human   130 A----------GLAAGSGPCLPQPSS--------------LPPLIPGGHATVSG--PGVARGFAS 168

  Fly   195 PTSSGRHNHQAPGNGNMGNKLQQQQQQQHKLQQQQRQARSCAA-----GSGGSGAESGSDSD--- 251
            |..:||    |.|.       |.|..:...|       .:||.     |||.:|.|...:.|
Human   169 PLGAGR----ASGE-------QWQPPRPAPL-------AACAQLQLLDGSGAAGQEELEEDDAFI 215

  Fly   252 SVKIP----LKVSNLGSGGGVAGGAGS---KLLPLRERTFSNGASDQNLQPERRARLNTAPGMRV 309
            ||::|    |.....|||.|..|...|   .:||:   .||...|......|:       || :.
Human   216 SVQVPAAAFLGSGTPGSGSGSRGRLNSFTQGILPI---AFSRPTSQNYCSLEQ-------PG-QG 269

  Fly   310 GSNSSIAMGGGLKRTYVLSGSSVSHITDDSSTESLTPAGNYAGSFRNSLSKSVQISDSRRGTSGQ 374
            ||.|:.......:|..:...||:..:.|......|......:||.|....|.:....:.|
Human   270 GSTSAFEQLQRSRRRLISQRSSLETLEDIEENAPLRRCRTLSGSPRPKNFKKIHFIKNMR----- 329

  Fly   375 PLGLGQARDERMVLVSRKIPF-FIFSSLPYYKGKNGRAEFRKEDRRRRNPSTSRPLSSINDAPFD 438
               ....|:.|:||:|.:..| .|||.|| |:......:.:.:..|:...:.|  |..|
Human   330 ---QHDTRNGRIVLISGRRSFCSIFSVLP-YRDSTQVGDLKLDGGRQSTGAVS--LKEI------ 382

  Fly   439 PFDLLGIQKAESGQDISYGHLLIPSRQYEKERKKHGNASANPSIFENQMEITSTAALKNHGIARC 503
             ..|.|::....|:.:||...|:|:..:...|              |.::.||:
Human   383 -IGLEGVELGADGKTVSYTQFLLPTNAFGARR--------------NTIDSTSS----------- 421

  Fly   504 FTYENN--------NRNSATSPTPDMKLDMDIESVILGGDSSRGQVYSASILDDPELIAGKHRTL 560
            |:...|        .|.|.|..:.|           .|.|......|..::||||:...|||:.:
Human   422 FSQFRNLSHRSLSIGRASGTQGSLD-----------TGSDLGDFMDYDPNLLDDPQWPCGKHKRV 475

  Fly   561 LTFTSYMTSVIDYVRPSDLKKELNDKFREKFPTIQLTLSKLRSIKREMRRINKLDSRIDLVTISQ 625
            |.|.||||:|||||:||||||::|:.|:||||.|:|||||:||:|||||::.:.|..::..|::.
Human   476 LIFPSYMTTVIDYVKPSDLKKDMNETFKEKFPHIKLTLSKIRSLKREMRKLAQEDCGLEEPTVAM 540

  Fly   626 AYVYFEKLILANLINKSNRKLCAGACLLLSAKM-NDVKGDALKSLIEKTESVFRLNRKELISSEF 689
            |:||||||.|...:||.|||||||||:||:||: :|:|...:|.||:|.|..|||||:|||:.||
Human   541 AFVYFEKLALKGKLNKQNRKLCAGACVLLAAKIGSDLKKHEVKHLIDKLEEKFRLNRRELIAFEF 605

  Fly   690 AVLVALEFSLHVNRHEVLPHYQRLLYES 717
            .|||||||:||:..|||:|||:||:..|
Human   606 PVLVALEFALHLPEHEVMPHYRRLVQSS 633

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6191	NP_001260958.1	CYCLIN_CABLES	596..713	CDD:410259	69/117 (59%)
CABLES1	NP_001094089.1	Interaction with TDRD7. /evidence=ECO:0000250	1..109		19/48 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..99		18/38 (47%)
		Interaction with CDK3. /evidence=ECO:0000250	179..492		96/384 (25%)
		CYCLIN_CABLES1	502..633	CDD:410305	77/130 (59%)