DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6191 and Cables1

DIOPT Version :9

Sequence 1:	NP_001260958.1	Gene:	CG6191 / 36513	FlyBaseID:	FBgn0027581	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_001139759.1	Gene:	Cables1 / 63955	MGIID:	1927065	Length:	594	Species:	Mus musculus

Alignment Length:	742	Identity:	218/742 - (29%)
Similarity:	309/742 - (41%)	Gaps:	223/742 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LNKTR--HRRRLAAISFLSNISLDGTH--RDTKFGATFGSSLLCNQNKNPSSLGLGSGGFHPHYQ 65
            |.|.|  .|||.||:|||:||||||..  :|.::|.                 |...||..|
Mouse    47 LRKPRMDPRRRQAALSFLTNISLDGRPPLQDHEWGG-----------------GEEGGGTKP--- 91

  Fly    66 QHHHQRSHSATHHNHQKRHHTQQQQQQQQQQHTQQQQQQQQHQQQHQQQQQHQNGALCSPLLCSA 130
                                                                  ||.....|.:|
Mouse    92 ------------------------------------------------------GARARLSLLAA 102

  Fly   131 DVHMGIDGGIGLGLGLEDCTTGASDGDGHFSETENMGQYLMNVLPAADHNRSSIVPAERRNIKRP 195
                             .|...::.|......|...|.....:.|       |:||   |.:..|
Mouse   103 -----------------GCNAFSAPGTAAAPWTAGSGSSPCPLPP-------SLVP---RVLGEP 140

  Fly   196 TSSGRHNHQAPGNGNMGNKLQQQQQQQHKLQQQQRQARSCAAGSGGSGAESGSDSD---SVKIPL 257
            :...|   .||  ...|.:||...                  |.||:|.|...:.|   :|::|
Mouse   141 SQPPR---SAP--AVTGAQLQLPD------------------GPGGAGQEELEEDDAFTNVQVP- 181

  Fly   258 KVSNLGSG--GGVAGGAGSKLLPLRERTFSNGA-----SDQNLQPERRARLNTAPGMRVGSNSSI 315
            ..|.||||  |..:|..|      |..:|:.|.     |.||.| ...|...:..|   ||.|::
Mouse   182 SASFLGSGTPGSTSGSRG------RLNSFTQGILPIAFSRQNSQ-NYCALEQSGQG---GSTSAL 236

  Fly   316 AMGGGLKRTYVLSGSSVSHITDDSSTESLTPAGNYAGSFRNSLSKSVQISDSRRGTSGQPLGLGQ 380
            ......:|..:...||:..:.|......|......:||.|....|.:....:.|        ...
Mouse   237 EQLQRSRRRLISQRSSLETLEDIEENAPLRRCRTLSGSPRPKNFKKIHFIKNMR--------QHD 293

  Fly   381 ARDERMVLVSRKIPF-FIFSSLPYYKGKNGRAEFRKEDRRRRNPSTSRPLSSINDAPFDP----- 439
            .::.|:||:|.:..| .|||.|||                       |..:.:.|...|.
Mouse   294 TKNGRIVLISGRRSFCSIFSVLPY-----------------------RDSTQVGDLKLDGGRQSA 335

  Fly   440 -----FDLLGIQKAESGQD---ISYGHLLIPSRQYEKERKKHGNASANPSIFENQMEITSTAALK 496
                 .:::|::..|.|.|   :||...|:|:..:...|.                .|.|||:..
Mouse   336 GAMSLKEIIGLEGVELGADGKTVSYTQFLLPTNAFGNRRN----------------TIDSTASFS 384

  Fly   497 NHGIARCFTYENNNRNSATSPTPDMKLDMDIESVILGGDSSRGQVYSASILDDPELIAGKHRTLL 561
            ..   |..::.:.:...|.|....:....|:      ||.   ..|..::||||:...|||:.:|
Mouse   385 QF---RSLSHRSLSMGRAGSTQGSLDAGSDL------GDF---MDYDPNLLDDPQWPCGKHKRVL 437

  Fly   562 TFTSYMTSVIDYVRPSDLKKELNDKFREKFPTIQLTLSKLRSIKREMRRINKLDSRIDLVTISQA 626
            ||.||||:|||||:||||||::|:.|:||||.|:|||||:||:|||||::.:.|...:..|::.|
Mouse   438 TFPSYMTTVIDYVKPSDLKKDMNETFKEKFPHIKLTLSKIRSLKREMRKLAQEDCGFEEPTVAMA 502

  Fly   627 YVYFEKLILANLINKSNRKLCAGACLLLSAKM-NDVKGDALKSLIEKTESVFRLNRKELISSEFA 690
            :||||||.|...:||.|||||||||:||:||: :|::...:|.||:|.|..|||||:|||:.||.
Mouse   503 FVYFEKLALRGKLNKQNRKLCAGACVLLAAKVGSDLRKHEVKHLIDKLEEKFRLNRRELIAFEFP 567

  Fly   691 VLVALEFSLHVNRHEVLPHYQRLLYES 717
            |||||||:||:..|||:|||:||:..|
Mouse   568 VLVALEFALHLPEHEVMPHYRRLIQSS 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6191	NP_001260958.1	CYCLIN	579..699	CDD:294043	70/120 (58%)
Cables1	NP_001139759.1	CYCLIN	477..562	CDD:238003	44/84 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830690
Domainoid	1	1.000	137	1.000	Domainoid score	I4881
eggNOG	1	0.900	-	-		E1_KOG4164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	250	1.000	Inparanoid score	I3211
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002600
OrthoInspector	1	1.000	-	-		otm42723
orthoMCL	1	0.900	-	-		OOG6_103855
Panther	1	1.100	-	-	O	PTHR22896
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4293
SonicParanoid	1	1.000	-	-		X2314
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.780