Protein Alignment CG13334 and MDH1

DIOPT Version :10

• Sequence 1: NP_610888.2
• Gene: CG13334 / 36510
• FlyBaseID: FBgn0033856
• Length: 361
• Species: Drosophila melanogaster
• Sequence 2: NP_001303303.1
• Gene: MDH1 / 4190
• HGNCID: 6970
• Length: 353
• Species: Homo sapiens
• Alignment Length: 319
• Identity: 81/319 - (25%)
• Similarity: 141/319 - (44%)
• Gaps: 38/319 - (11%)

  Fly    54 VGAGQV-GTAISAMLLLRNLTKNLVILDINYELAKAEALDFQHASAFLSDARVVPCGDSTNSKDS 117
            :|.|.| |.....:|:|.::|..:.:||       ...::.|..:..|....:....:....||.
Human    24 IGNGSVFGKDQPIILVLLDITPMMGVLD-------GVLMELQDCALPLLKDVIATDKEDVAFKDL 81

  Fly   118 DVVIITAGARPSGKDRSRLAAMQKTVEILKK---AVPKLVELSPNATFIIISNPADV--MTYAVQ 177
            ||.|: .|:.|..:...|...::..|:|.|.   |:.|..:.|  ...|::.|||:.  :| |.:
Human    82 DVAIL-VGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKS--VKVIVVGNPANTNCLT-ASK 142

  Fly   178 RITNLPKHR--CFTTGCHLDTVRFRNLIANRLRLPPSQVHGYVI-GEHGASAVPVWSSVSIAGIR 239
            ...::||..  |.|   .||..|.:..||.:|.:..:.|...:| |.|.::..|   .|:.|.::
Human   143 SAPSIPKENFSCLT---RLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYP---DVNHAKVK 201

  Fly   240 L--NDVVKNLACGDDPENWAKINKQVTT---GGLAVAKTKGYTN-WAIALTCADIVQAMSGG--K 296
            |  .:|....|..||  :|.| .:.|||   .|.||.|.:..:: .:.|....|.|:.:..|  :
Human   202 LQGKEVGVYEALKDD--SWLK-GEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPE 263

  Fly   297 GKIACVGTDMKGLN-GIQDNVVLSLPCLVTAGGISHVFELPLTDVEQSKLLASANILLE 354
            |:...:|....|.: |:.|:::.|.|.::.......|..||:.|..:.|:..:|..|.|
Human   264 GEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTE 322

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG13334	NP_610888.2	LDH_1	46..358	CDD:133429	81/319 (25%)
MDH1	NP_001303303.1	MDH_cytoplasmic_cytosolic	3..328	CDD:133421	81/319 (25%)
		PTS1	351..353