DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PDX1 and Antp

DIOPT Version :9

Sequence 1:	NP_000200.1	Gene:	PDX1 / 3651	HGNCID:	6107	Length:	283	Species:	Homo sapiens
Sequence 2:	NP_996167.1	Gene:	Antp / 40835	FlyBaseID:	FBgn0260642	Length:	378	Species:	Drosophila melanogaster

Alignment Length:	302	Identity:	90/302 - (29%)
Similarity:	114/302 - (37%)	Gaps:	122/302 - (40%)

- Green bases have known domain annotations that are detailed below.

Human     4 EEQYYAATQLYKDPCAFQRGPAPEFSASPPACLYMGRQPPPPPPHPFPGALGALEQGSPPDISPY 68
            ::|....||....|...|:.|....|....|.:               |.||.:.:|..
  Fly   136 QQQLPQVTQQVTHPQQQQQQPVVYASCKLQAAV---------------GGLGMVPEGGS------ 179

Human    69 EVPPLADDPAVAHLHHHLPAQLALPH--------------------------------------P 95
              |||.|..:    .||:.||:.|||                                      |
  Fly   180 --PPLVDQMS----GHHMNAQMTLPHHMGHPQAQLGYTDVGVPDVTEVHQNHHNMGMYQQQSGVP 238

Human    96 PAGPFPEG-------------AEPGVLEEPNRVQLP-----------FPWMKSTKAHAWKGQWAG 136
            |.|..|:|             ..||....|:  |.|           :|||:|
  Fly   239 PVGAPPQGMMHQGQGPPQMHQGHPGQHTPPS--QNPNSQSSGMPSPLYPWMRS------------ 289

Human   137 GAYAAEPEENKRTRTAYTRAQLLELEKEFLFNKYISRPRRVELAVMLNLTERHIKIWFQNRRMKW 201
              ...:.:|.||.|..|||.|.|||||||.||:|::|.||:|:|..|.||||.||||||||||||
  Fly   290 --QFGKCQERKRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKW 352

Human   202 KKEEDKKRGGGTAVGGGGVAEPEQDCAVTSGEELLALPPPPP 243
            || |:|.:|   ..|.||           .|:|:  .||..|
  Fly   353 KK-ENKTKG---EPGSGG-----------EGDEI--TPPNSP 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PDX1	NP_000200.1	Transactivation domain. /evidence=ECO:0000250	13..73		10/59 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	34..71		5/36 (14%)
		Antp-type hexapeptide	118..123		3/15 (20%)
		Homeobox	149..202	CDD:278475	36/52 (69%)
		Nuclear localization signal. /evidence=ECO:0000250	197..203		5/5 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..283		14/43 (33%)
Antp	NP_996167.1	KLF1_2_4_N	<161..306	CDD:425360	36/187 (19%)
Antp	NP_996167.1	Homeobox	301..354	CDD:395001	37/52 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810