Protein Alignment PDX1 and Scr

DIOPT Version :9

• Sequence 1: NP_000200.1
• Gene: PDX1 / 3651
• HGNCID: 6107
• Length: 283
• Species: Homo sapiens
• Sequence 2: NP_001368995.1
• Gene: Scr / 40833
• FlyBaseID: FBgn0003339
• Length: 564
• Species: Drosophila melanogaster
• Alignment Length: 311
• Identity: 95/311 - (30%)
• Similarity: 120/311 - (38%)
• Gaps: 99/311 - (31%)

Human    61 SPPDISPYEVPP-----------------------LADDPAVAHLHHHL--------PAQLALP- 93
            ||.|:|..::.|                       ||...|.|.|:::.        |..:.:|
  Fly   206 SPQDLSTRDISPKLSPSSVVESVARSLNKGVLGGSLAAAAAAAGLNNNHSGSGVSGGPGNVNVPM 270

Human    94 HPPAG-----PFPEGAEPGVLE-----EPNRVQLPFPWMKSTKAHAWKGQWAGGAYAAEPEENKR 148
            |.|.|     ....|.|.|..:     :.|..|: :||||  :.|      .|.:......|.||
  Fly   271 HSPGGGDSDSESDSGNEAGSSQNSGNGKKNPPQI-YPWMK--RVH------LGTSTVNANGETKR 326

Human   149 TRTAYTRAQLLELEKEFLFNKYISRPRRVELAVMLNLTERHIKIWFQNRRMKWKKEE-------- 205
            .||:|||.|.|||||||.||:|::|.||:|:|..|.||||.|||||||||||||||.
  Fly   327 QRTSYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEHKMASMNIV 391

Human   206 ---------------------------DKKRGGGTAVGGGGV-AEPEQDCAVTSGEE-LLALPPP 241
                                       |.....||......: .||.|..|..|... ..:....
  Fly   392 PYHMGPYGHPYHQFDIHPSQFAHLSAXDAWHFSGTGXRLNQLYQEPYQTAAAASAASGYQSQDGG 456

Human   242 PPPGGAV--------PPAAPVAAREGRLPPGLSASPQPSSVAP---RRPQE 281
            |..||:|        |.:.......|..|..|.||...||.||   :.|||
  Fly   457 PIGGGSVGVGGGAGGPGSLANGGSNGSGPNSLFASAASSSQAPDCIKYPQE 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PDX1	NP_000200.1	Transactivation domain. /evidence=ECO:0000250	13..73		5/34 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	34..71		4/9 (44%)
		Antp-type hexapeptide	118..123		2/4 (50%)
		Homeobox	149..202	CDD:278475	37/52 (71%)
		Nuclear localization signal. /evidence=ECO:0000250	197..203		5/5 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	201..283		29/129 (22%)
Scr	NP_001368995.1	Homeobox	328..381	CDD:395001	38/52 (73%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810