DRSC/TRiP Functional Genomics Resources

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Protein Alignment PDX1 and zen2

DIOPT Version :10

Sequence 1:NP_000200.1 Gene:PDX1 / 3651 HGNCID:6107 Length:283 Species:Homo sapiens
Sequence 2:NP_476794.1 Gene:zen2 / 40827 FlyBaseID:FBgn0004054 Length:252 Species:Drosophila melanogaster


Alignment Length:161 Identity:56/161 - (34%)
Similarity:83/161 - (51%) Gaps:38/161 - (23%)


- Green bases have known domain annotations that are detailed below.


Human   144 EENKRTRTAYTRAQLLELEKEFLFNKYISRPRRVELAVMLNLTERHIKIWFQNRRMKWKKEEDKK 208
            |::||:|||::..||:|||:||..|||::|.||:|::..|.||||.:||||||||||.||..::|
  Fly    41 EKSKRSRTAFSSLQLIELEREFHLNKYLARTRRIEISQRLALTERQVKIWFQNRRMKLKKSTNRK 105

Human   209 RGGGTAVGGGGVAEP---------EQDCAVTSGEELLALPPPPPPGGAVPPAAPV------AARE 258
                .|:|....:.|         ::|..:.  |.||..      .......||:      ...|
  Fly   106 ----GAIGALTTSIPLSSQSSEDLQKDDQIV--ERLLRY------ANTNVETAPLRQVDHGVLEE 158

Human   259 GRLPPGLSA-------SPQPSSVAPRRPQEP 282
            |::.|...:       ||:|.::    ||.|
  Fly   159 GQITPPYQSYDYLHEFSPEPMAL----PQLP 185

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PDX1NP_000200.1 Transactivation domain. /evidence=ECO:0000250 13..73
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 34..71
Antp-type hexapeptide 118..123
Homeodomain 147..203 CDD:459649 34/55 (62%)
Nuclear localization signal. /evidence=ECO:0000250 197..203 4/5 (80%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 201..283 21/104 (20%)
zen2NP_476794.1 Homeodomain 44..100 CDD:459649 34/55 (62%)
Blue background indicates that the domain is not in the aligned region.

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