DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PDX1 and zen2

DIOPT Version :9

Sequence 1:	NP_000200.1	Gene:	PDX1 / 3651	HGNCID:	6107	Length:	283	Species:	Homo sapiens
Sequence 2:	NP_476794.1	Gene:	zen2 / 40827	FlyBaseID:	FBgn0004054	Length:	252	Species:	Drosophila melanogaster

Alignment Length:	161	Identity:	56/161 - (34%)
Similarity:	83/161 - (51%)	Gaps:	38/161 - (23%)

- Green bases have known domain annotations that are detailed below.

Human   144 EENKRTRTAYTRAQLLELEKEFLFNKYISRPRRVELAVMLNLTERHIKIWFQNRRMKWKKEEDKK 208
            |::||:|||::..||:|||:||..|||::|.||:|::..|.||||.:||||||||||.||..::|
  Fly    41 EKSKRSRTAFSSLQLIELEREFHLNKYLARTRRIEISQRLALTERQVKIWFQNRRMKLKKSTNRK 105

Human   209 RGGGTAVGGGGVAEP---------EQDCAVTSGEELLALPPPPPPGGAVPPAAPV------AARE 258
                .|:|....:.|         ::|..:.  |.||..      .......||:      ...|
  Fly   106 ----GAIGALTTSIPLSSQSSEDLQKDDQIV--ERLLRY------ANTNVETAPLRQVDHGVLEE 158

Human   259 GRLPPGLSA-------SPQPSSVAPRRPQEP 282
            |::.|...:       ||:|.::    ||.|
  Fly   159 GQITPPYQSYDYLHEFSPEPMAL----PQLP 185

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PDX1	NP_000200.1	Transactivation domain. /evidence=ECO:0000250	13..73
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	34..71
		Antp-type hexapeptide	118..123
		Homeobox	149..202	CDD:278475	32/52 (62%)
		Nuclear localization signal. /evidence=ECO:0000250	197..203		4/5 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..283		21/104 (20%)
zen2	NP_476794.1	Homeobox	46..99	CDD:278475	32/52 (62%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810