DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PDX1 and unpg

DIOPT Version :9

Sequence 1:	NP_000200.1	Gene:	PDX1 / 3651	HGNCID:	6107	Length:	283	Species:	Homo sapiens
Sequence 2:	NP_477146.1	Gene:	unpg / 35942	FlyBaseID:	FBgn0015561	Length:	485	Species:	Drosophila melanogaster

Alignment Length:	330	Identity:	90/330 - (27%)
Similarity:	119/330 - (36%)	Gaps:	114/330 - (34%)

- Green bases have known domain annotations that are detailed below.

Human     7 YYA-----ATQLYKDPCAFQRGPAPEFSASPPACLYMGRQPPPPPPHPFPGALGALEQGSPPDI- 65
            |:|     .|.|....|.....||...:|..|..   ..||.||||||   ...|||:..||.:
  Fly    92 YFAQNHERLTHLIAGGCYLPSSPAGHPAAQQPQA---QAQPQPPPPHP---PTHALEKQLPPTLP 150

Human    66 SPYEVPPLADDPAVAHLH------------------HHLPAQLALPH-PPAGPFPEG-AEPGV-- 108
            .|.:...|..:||.|.:.                  |.|.....|.| ..||...|. |.||:
  Fly   151 HPLDTRFLPFNPAAAGVAPTDLSYRRLAELMNQDYVHSLSVHARLQHMAAAGRMHEDQANPGMAQ 215

Human   109 LEEPNRVQLPFPWMKSTKAHA--------------------------------WKGQW---AGGA 138
            |:||...|......|| .:|:                                :.|:.   ..||
  Fly   216 LQEPTPPQAHSSPAKS-GSHSPMEPALDVGMDEDFECSGDSCSDISLTMSPRNYNGEMDKSRNGA 279

Human   139 YAAEPEE--------------------------------NKRTRTAYTRAQLLELEKEFLFNKYI 171
            |.....|                                ::|.|||:|..||||||:||...||:
  Fly   280 YTNSDSEDCSDDEGAQSRHEGGGMGGKDSQGNGSSSNSKSRRRRTAFTSEQLLELEREFHAKKYL 344

Human   172 SRPRRVELAVMLNLTERHIKIWFQNRRMKWKKEEDKKRGGGTAVGGGGVAEPEQDCAVTSGEELL 236
            |...|.::|..|.|:|..:||||||||.|||    :.:.|.|:.|.|       ....|||.:::
  Fly   345 SLTERSQIATSLKLSEVQVKIWFQNRRAKWK----RVKAGLTSHGLG-------RNGTTSGTKIV 398

Human   237 ALPPP 241
             :|.|
  Fly   399 -VPIP 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PDX1	NP_000200.1	Transactivation domain. /evidence=ECO:0000250	13..73		20/60 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	34..71		14/37 (38%)
		Antp-type hexapeptide	118..123		0/4 (0%)
		Homeobox	149..202	CDD:278475	29/52 (56%)
		Nuclear localization signal. /evidence=ECO:0000250	197..203		4/5 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..283		11/41 (27%)
unpg	NP_477146.1	Homeobox	324..375	CDD:278475	28/50 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810