DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Roe1 and GRPEL2

DIOPT Version :9

Sequence 1:	NP_610886.2	Gene:	Roe1 / 36508	FlyBaseID:	FBgn0014877	Length:	213	Species:	Drosophila melanogaster
Sequence 2:	NP_689620.2	Gene:	GRPEL2 / 134266	HGNCID:	21060	Length:	225	Species:	Homo sapiens

Alignment Length:	178	Identity:	75/178 - (42%)
Similarity:	101/178 - (56%)	Gaps:	25/178 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 EEATEQKATESSPEVEKLTKELAAAKEQNAELMDKYKRSLADSENMRNRLNKQISDAKIFGIQSF 105
            |.|...||.:...||:.||.              :|:|::||.||:|.|..:.:.||||||||||
Human    59 ERALRVKAVKLEKEVQDLTV--------------RYQRAIADCENIRRRTQRCVEDAKIFGIQSF 109

  Fly   106 CKDLLEVADTLGHATQAV-----PKD-KLSGNADLKNLYEGLTMTRASLLQVFKRHGLEPLDPIN 164
            ||||:||||.|...|:.:     |:| ||:    |:.::.||.:..|.|..||.:||||.|.||.
Human   110 CKDLVEVADILEKTTECISEESEPEDQKLT----LEKVFRGLLLLEAKLKSVFAKHGLEKLTPIG 170

  Fly   165 QKFDPNQHEALFQ-KEDKTVEPNTVVEVTKLGYKLHERCIRPALVGVS 211
            .|:||::||.:.. .....|:|.||..|.:.|||||.|.||.|.|.|:
Human   171 DKYDPHEHELICHVPAGVGVQPGTVALVRQDGYKLHGRTIRLARVEVA 218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Roe1	NP_610886.2	GrpE	70..210	CDD:271355	66/146 (45%)
		2-helical coiled coil	70..120	CDD:271355	27/49 (55%)
		2-helical coiled coil	140..155	CDD:271355	6/14 (43%)
GRPEL2	NP_689620.2	GrpE	74..217	CDD:271355	68/160 (43%)
		2-helical coiled coil	74..124	CDD:271355	29/63 (46%)
		2-helical coiled coil	146..161	CDD:271355	6/14 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147768
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0576
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61230
OrthoDB	1	1.010	-	-		D1525208at2759
OrthoFinder	1	1.000	-	-		FOG0001525
OrthoInspector	1	1.000	-	-		otm42146
orthoMCL	1	0.900	-	-		OOG6_100642
Panther	1	1.100	-	-	O	PTHR21237
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1249
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.720