Protein Alignment mip120 and lin54

DIOPT Version :10

• Sequence 1: NP_001163143.1
• Gene: mip120 / 36499
• FlyBaseID: FBgn0033846
• Length: 952
• Species: Drosophila melanogaster
• Sequence 2: NP_001070035.1
• Gene: lin54 / 560688
• ZFINID: ZDB-GENE-060929-440
• Length: 771
• Species: Danio rerio
• Alignment Length: 810
• Identity: 239/810 - (29%)
• Similarity: 355/810 - (43%)
• Gaps: 205/810 - (25%)

  Fly   251 TSPSLAQPNKIQV-VRTADGKIIKI---NQAGPSLLVNAKQGTGTT----VTPGGSAATSVK--- 304
            |.|..:.|...|| :.|...:||.|   ..:..::..|||..|.:|    :||..|::|:.|
Zfish    32 TPPPQSAPESAQVPMETEVPEIISICPTTASMQAISTNAKSTTSSTTQLLLTPSSSSSTTTKNAT 96

  Fly   305 --------LS-PSTGNVVLNKPVGQVVVRTETPVKTATGSVASASATPGKMLVQSGGKQILV--- 357
                    || |....:::||                   ||:...:||..:::..|:::||
Zfish    97 PTLPKIPSLSVPPNHQLIINK-------------------VAADGKSPGGAVIKQEGQKLLVAGL 142

  Fly   358 --SNKNIIKLSPNASATSSTTHTTGGQTPSTSSGLHAIQLPGKGGIQYVRVLNNNKSAAGTSATA 420
              :.:.|:...|:|....:|:..: |...|..:.:..:...||..|..        |:|.....:
Zfish   143 SKTGQPIMLALPHAWNKPATSQGS-GDAKSQPTQIKMVTAMGKPVIAV--------SSASQLVAS 198

  Fly   421 SIP------KTVQTQKITVVRPPAATGVP------ATSTTTSAAAASPAAASKANLAMGNTNKIV 473
            |.|      ||:|..|    :||.:|..|      .|....:...:||.:.|..     .|.::|
Zfish   199 STPLQAQHLKTLQITK----KPPVSTAGPMITKLIITKALNNKVLSSPGSVSPV-----VTGRVV 254

  Fly   474 MRS----------MGGSIVPLPSVQTLVSKRALGAISNASK---PASAASSSATPSASQELPRKH 525
            .:|          :|.:|..:|......||.|:..:.:.||   .:..:.||.:|..|..||...
Zfish   255 SQSTPLTPPRTIAIGETISTVPQNAATNSKVAISPLKSPSKLTVVSVTSQSSNSPQKSMTLPLNV 319

  Fly   526 RLTDLNVQLKQSASVSSEASDSSDAGPEAKKPRYVITMQQGSQKAA--------SQPVQ------ 576
            .|....:.::|||..|...:.||.:..:..||...:|:.....|..        .|.:|
Zfish   320 ALGQQILTVQQSAVTSPAKAGSSQSTTQTVKPVQTVTVPTSQFKTIIPLTTPPNVQQIQVPGSRF 384

  Fly   577 ---KLINRT---ANVQRVVSSSTSPSSNSTKKIYNYVQPTGSNGAKYMICNSGVPQSSTSAMRRG 635
               :|:..|   :.||...|::|:||          :||     ||.::.|:.|
Zfish   385 HYVRLVTATTGSSTVQTGGSTNTNPS----------IQP-----AKPVMMNAAV----------- 423

  Fly   636 YTGYVENKTRRPPPISPQQHRFKQMGPQQQSKHQQLQAQAKQRIRQQQLPTEQSTPI----KVEP 696
                     |...||.|.| ..||:.|:..|       .|.|.:...|.|.....|.    :::|
Zfish   424 ---------RMSVPIVPAQ-TAKQVVPKPLS-------SAAQVVTTSQTPQRLIMPATHLPQIQP 471

  Fly   697 KLPTLPPGV-------KANV-----PAKPLFEVLKP------------PATAAAAGAVDPLGGMT 737
            .|..||||.       ..||     ||..:.::.:|            .||.:.|.|...|.|::
Zfish   472 NLTNLPPGTVLAPAHGSGNVGYAVLPAPYVTQIPQPAFVTLTSSSTFSTATPSQAQARLSLNGLS 536

  Fly   738 SR------RKHCNCSKSQCLKLYCDCFANGEFCQDCTCKDCFNNLDYEVERERAIRSCLDRNPSA 796
            :.      ||.|||::|||||||||||||||||.:|.|.:||||||:|.||.:||::||||||.|
Zfish   537 TSEANSRPRKPCNCTRSQCLKLYCDCFANGEFCNNCNCVNCFNNLDHESERLKAIKACLDRNPVA 601

  Fly   797 FKPKITAPNSGDM-RLHNKGCNCKRSGCLKNYCECYEAKIPCSSICKCVGCRNMEDRPD-VDMDS 859
            |||||.....|:. |.|:||||||:|||||||||||||||.|||||||:||:|.|:.|: ..:..
Zfish   602 FKPKIGKGKEGESDRRHSKGCNCKKSGCLKNYCECYEAKIMCSSICKCMGCKNFEESPERKTLMH 666

  Fly   860 LDGLMGVEGQKKDKAKNKQLNENRANI------------------YFTDDVIEATIMCMISRIVM 906
            |.....|..|::..||.| |:...:::                  :.|.:|.|||..|::.:...
Zfish   667 LADAAEVRVQQQTAAKTK-LSSQISDLLTRTTPAITSGGGKLPYTFVTKEVAEATCDCLLEQAEQ 730

  Fly   907 HEKQNVAVEDMEREVMEEMGESLTQIIAFA 936
            .|..|......||.::||.|..|.:||:||
Zfish   731 AELTNQPQAMAERLILEEFGRCLHRIISFA 760

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mip120	NP_001163143.1	TCR	740..775	CDD:461001	26/34 (76%)
		TCR	813..850	CDD:461001	31/36 (86%)
lin54	NP_001070035.1	PHA03247	<14..508	CDD:223021	124/555 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	21..44		3/11 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	68..105		10/36 (28%)
		TCR	545..>566	CDD:461001	17/20 (85%)
		DNA-binding. /evidence=ECO:0000250|UniProtKB:Q6MZP7	546..559		9/12 (75%)
		Linker. /evidence=ECO:0000250|UniProtKB:Q6MZP7	606..619		3/12 (25%)
		TCR	619..654	CDD:461001	30/34 (88%)
		DNA-binding. /evidence=ECO:0000250|UniProtKB:Q6MZP7	622..635		11/12 (92%)