DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mip120 and Lin54

DIOPT Version :9

Sequence 1:	NP_001163143.1	Gene:	mip120 / 36499	FlyBaseID:	FBgn0033846	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	XP_006534946.1	Gene:	Lin54 / 231506	MGIID:	2140902	Length:	767	Species:	Mus musculus

Alignment Length:	989	Identity:	271/989 - (27%)
Similarity:	384/989 - (38%)	Gaps:	313/989 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LTDSLDDTEPLPELSFEDFLEPTSEKSSQHMEIEALDSEEDNIGGEDLADPAND------SLNTP 67
            |.|.:.||  ...|..||.:|.....|...||.|..:....|..|:..|.|.:.      |.:|.
Mouse    30 LPDDIMDT--AITLVDEDSIEAVIVSSPIPMETELEEIVNINSTGDSTATPISTEPITVYSNHTN 92

  Fly    68 QFKKNVVHILEDKRLNSSGLTVLKSHAIKMVTAGGTPPAKAQVTDVKILNKLKPIPSSTLKIGST 132
            |...|......|     |..||..:....:...|...|.......: ||||:.  .:|.||:|:.
Mouse    93 QVAVNTTVSKAD-----SNTTVKPAFPSGLQKLGAQTPVTISANQI-ILNKVS--QTSDLKLGNQ 149

  Fly   133 TIATKSTPGSITKTLGNLTQIRTKDGQVIFVQKSVPGTQSSTA--VTGSPSGGIRRLVAPSGIQK 195
            |:........:| |||       |.|..|.:  ::|.:|...|  ||.....|..:| .|..|
Mouse   150 TLKPDGQKLILT-TLG-------KSGSPIVL--ALPHSQLPQAQKVTAQAQPGDAKL-PPQQI-- 201

  Fly   196 AVLSKGVTMASTGLVKAAVPAKASTSVPGSAITLKGIQPLAGGTAKASTSSTTATTSPSLAQPNK 260
                |.||:.....||..:...|.|  |||.:                   ...||.||:.|..:
Mouse   202 ----KVVTIGGRPEVKPVIGVSALT--PGSQL-------------------INTTTQPSVLQTQQ 241

  Fly   261 IQVVRTA-------DGKII-KINQAGPSLLVNAKQGTGTTVTPGGSAATSVKLSPSTGNVVLNKP 317
            ::.|:.|       .|.:| |:..|.|   :|:|..||.|........|...||.||..
Mouse   242 LKTVQIAKKPRTPTSGPVITKLIFAKP---INSKAVTGQTTQASPPVVTGRVLSQSTPG------ 297

  Fly   318 VGQVVVRTETPVKTAT--------GSVASASATPGKMLVQSGGKQILVSNKNIIKLSPNASATSS 374
                     ||.||.|        .::.|.:.||.|:.:..            :| |||.:..|:
Mouse   298 ---------TPSKTITISESGVIGSTLNSTTQTPNKIAISP------------LK-SPNKTVKSA 340

  Fly   375 T-THTTGGQTPS---------TSSGLHAIQLPGKGGIQYVRVLNNNKSAAGTSATASIPKTVQTQ 429
            . |.|.||.:.|         |:..:..||:|| ....|||::        |:.|||......:|
Mouse   341 VQTITVGGMSTSQFKTIIPLATAPNVQQIQVPG-SKFHYVRLV--------TATTASSSAQPVSQ 396

  Fly   430 KITVVRPPAATGVPATSTTTSAAAASPAAASKANLAMGNTNKIVMRSMGGSIVPLPSVQTLVSKR 494
            ..:|...|.....|....||....:.|...::|      ..::|.:       |:.|...:|:
Mouse   397 SPSVNTQPLQQAKPVVVNTTPVRMSVPFVQAQA------VKQVVPK-------PINSTSQIVT-- 446

  Fly   495 ALGAISNASKPASAASSSATPSASQELPR-KHRLTDLNVQLKQSASVSSEASDSSDAGPEAKKPR 558
                   .|:|.......|||     ||: :..||:|     ...:|.:.|..:.:.|......:
Mouse   447 -------TSQPQQRLIMPATP-----LPQIQPNLTNL-----PPGTVLAPAPGTGNVGYAVLPAQ 494

  Fly   559 YVITMQQGSQKAASQPVQKLINRTANVQRVVSSSTSPSSNSTKKIYNYVQPTGSNGAKYMICNSG 623
            ||..:||                        ||..|.:|||     |:   ||::|
Mouse   495 YVTQLQQ------------------------SSYVSIASNS-----NF---TGTSG--------- 518

  Fly   624 VPQSSTSAMRRGYTGYVENKTRRPPPISPQQHRFKQMGPQQQSKHQQLQAQAKQRIRQQQLPTEQ 688
                                                           :|.||:       ||..
Mouse   519 -----------------------------------------------IQTQAR-------LPFN- 528

  Fly   689 STPIKVEPKLPTLPPGVKANVPAKPLFEVLKPPATAAAAGAVDPLGGMTSR-RKHCNCSKSQCLK 752
                           |:   :|::                       .||| ||.|||:||.|||
Mouse   529 ---------------GI---IPSE-----------------------STSRPRKPCNCTKSLCLK 552

  Fly   753 LYCDCFANGEFCQDCTCKDCFNNLDYEVERERAIRSCLDRNPSAFKPKITAPNSGDM-RLHNKGC 816
            ||||||||||||.:|.|.:|:|||::|.||::||::||||||.||||||.....|:. |.|:|||
Mouse   553 LYCDCFANGEFCNNCNCTNCYNNLEHENERQKAIKACLDRNPEAFKPKIGKGKEGESDRRHSKGC 617

  Fly   817 NCKRSGCLKNYCECYEAKIPCSSICKCVGCRNMEDRPD-VDMDSLDGLMGVEGQKKDKAKNK--- 877
            |||||||||||||||||||.|||||||:||:|.|:.|: ..:..|.....|..|::..||.|
Mouse   618 NCKRSGCLKNYCECYEAKIMCSSICKCIGCKNFEESPERKTLMHLADAAEVRVQQQTAAKTKLSS 682

  Fly   878 QLNE---------NRAN-----IYFTDDVIEATIMCMISRIVMHEKQNVAVEDMEREVMEEMGES 928
            |:::         |.|.     .:.|.:|.|||..|::::....:|:..:....||.::||.|..
Mouse   683 QISDLLTRPTPALNSAGGKLPFTFVTKEVAEATCNCLLAQAEQADKKGKSKAAAERMILEEFGRC 747

  Fly   929 LTQIIAFA-KEKQE 941
            |..:|..| |.|.:
Mouse   748 LMSVINSAGKAKSD 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mip120	NP_001163143.1	TCR	740..775	CDD:281618	25/34 (74%)
mip120	NP_001163143.1	TCR	813..850	CDD:281618	32/36 (89%)
Lin54	XP_006534946.1	PHA03247	<183..517	CDD:223021	107/465 (23%)
		TCR	541..>563	CDD:367588	18/21 (86%)
		TCR	615..649	CDD:367588	31/33 (94%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	1.000	Domainoid score	I8412
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	225	1.000	Inparanoid score	I3495
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003047
OrthoInspector	1	1.000	-	-		otm44354
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12446
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2613
SonicParanoid	1	1.000	-	-		X1765
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.090