DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mip120 and lin-54

DIOPT Version :9

Sequence 1:	NP_001163143.1	Gene:	mip120 / 36499	FlyBaseID:	FBgn0033846	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	NP_502544.1	Gene:	lin-54 / 178280	WormBaseID:	WBGene00003037	Length:	435	Species:	Caenorhabditis elegans

Alignment Length:	441	Identity:	141/441 - (31%)
Similarity:	195/441 - (44%)	Gaps:	127/441 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   577 KLINRTANVQRVVSSSTSPSSNSTKKIYNYVQPTGSNGAKYMICNSGVPQS---STSAMRRGYTG 638
            :|:....|:|   :....|.::|..:.:|          :.|..|.|:.:.   .||:.|    .
Worm    36 QLVPHNPNLQ---AQQNRPGTSSMIQQHN----------RSMEVNQGLVKDEPIDTSSHR----V 83

  Fly   639 YVENKTRRPPPISPQQHRFKQMGPQQQSKHQ-------QLQAQAKQRIRQQQLPTEQSTPIKVEP 696
            ||      ||| .|.|.:..|.||......|       .|........||     ..|.|..|:|
Worm    84 YV------PPP-RPVQRKLFQPGPSTPGSSQYTVRNLSNLSGSPSMYDRQ-----PASLPRTVQP 136

  Fly   697 KLPTLPPGVK-----------------ANVPAKPLFEVLKPPATAAAAGAVDPLGGMTSRRKHCN 744
            .      |::                 :::..|...:|..|                 .:||.||
Worm   137 M------GLEMGNSEQRKVYIDMKDHVSHIRLKTKKKVFAP-----------------GQRKPCN 178

  Fly   745 CSKSQCLKLYCDCFANGEFCQDCTCKDCFNNLDYEVERERAIRSCLDRNPSAFKPKITAPNSG-- 807
            |:||||||||||||||||||:||.||||.||::|:.:|.:|||..|:|||:||||||.....|
Worm   179 CTKSQCLKLYCDCFANGEFCRDCNCKDCHNNIEYDSQRSKAIRQSLERNPNAFKPKIGIARGGIT 243

  Fly   808 DM-RLHNKGCNCKRSGCLKNYCECYEAKIPCSSICKCVGCRNME-------DRPDVDMDSLDGLM 864
            |: |||.|||:||:||||||||||||||:||:..|||.||:|.|       ......:.:.:.||
Worm   244 DIERLHQKGCHCKKSGCLKNYCECYEAKVPCTDRCKCKGCQNTETYRMTRYKNSGGAVSNTNALM 308

  Fly   865 GVEGQKK----DKAKNKQLNENRAN----------------------IYFTDDVIEATIMCMISR 903
            .:.....    |......:.:...:                      .|.||:|:||..|||:::
Worm   309 SLTNASSTATPDSGPGSVVTDEHGDDYEDMLLSHKPKVEMDPRRFPWYYMTDEVVEAATMCMVAQ 373

  Fly   904 ---IVMHEKQNVAVED-----MEREVMEEMGESLTQIIAFAKEKQETSQID 946
               .:.:||  |..||     ||:.|:.|.|..|.|:|....|.  |..:|
Worm   374 AEEALNYEK--VQTEDEKLINMEKLVLREFGRCLEQMITNTTEL--TQDLD 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mip120	NP_001163143.1	TCR	740..775	CDD:281618	29/34 (85%)
mip120	NP_001163143.1	TCR	813..850	CDD:281618	27/36 (75%)
lin-54	NP_502544.1	TCR	174..209	CDD:281618	29/34 (85%)
lin-54	NP_502544.1	TCR	250..287	CDD:281618	27/36 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158684
Domainoid	1	1.000	79	1.000	Domainoid score	I5640
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003047
OrthoInspector	1	1.000	-	-		oto18187
orthoMCL	1	0.900	-	-		OOG6_106892
Panther	1	1.100	-	-	LDO	PTHR12446
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2613
SonicParanoid	1	1.000	-	-		X1765
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.870