DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mip120 and Tesmin

DIOPT Version :9

Sequence 1:	NP_001163143.1	Gene:	mip120 / 36499	FlyBaseID:	FBgn0033846	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	NP_001034746.1	Gene:	Tesmin / 17771	MGIID:	1340029	Length:	475	Species:	Mus musculus

Alignment Length:	528	Identity:	145/528 - (27%)
Similarity:	225/528 - (42%)	Gaps:	143/528 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   453 AASPA--AASK------ANLAMGNT--NKIVMRSMG---GSIVPLPSVQTLVSKRALGAISNASK 504
            |.|||  ||.:      |:..:|.|  .:.::|::.   |:.||...:........|.:..:|:.
Mouse    32 ALSPAGGAADRDELPVLADAYLGATEPGEPLLRALSPPPGAEVPAALLGDFPGLPELRSPDDAAP 96

  Fly   505 PASAA---SSSATPSASQE--LPRKHRLTDLNVQLKQS-ASV-SSEASDSSDAGPEAKKPRYVIT 562
            |.:.:   .||..|.|...  ||....:..:.|::|:: .|| .....|::...|.|::......
Mouse    97 PPAYSVHVLSSLLPGARGPALLPLSAGVRVIPVEIKEAGGSVPGGSPEDAAFQAPLAQESCCKFP 161

  Fly   563 MQQGSQKAASQPVQKLINRTANVQRVVSSSTSPSSNSTKKIYNYVQPTGSNGAKYMICNSGVPQS 627
            ..|.:::|:|.|.:|              .:||......|           |...|:|
Mouse   162 SSQEAEEASSCPRKK--------------DSSPMVICQLK-----------GGAQMLC------- 194

  Fly   628 STSAMRRGYTGYVENKTRRPPPISPQQHRFKQMGPQQQSKHQQLQAQAKQRIRQQQLPTEQST-- 690
                        ::|...|                :.::.|...|...:....|.:||...:|
Mouse   195 ------------IDNCGAR----------------ELKALHLLPQYDDQSSFPQSELPKPMTTLV 231

  Fly   691 ----PIKVEPKLPT------LPPGVKANVPAKPLFEVLKPPATAAAAGAVDPLGGMTSRRKHCNC 745
                |:..:..|.|      ||..|  |..|.|....|:.|.....:|
Mouse   232 GRLLPVPAKLNLITQVDNGALPSAV--NGAAFPSGPALQGPPKITLSG----------------- 277

  Fly   746 SKSQCLKLYCDCFANGEFCQDCTCKDCFNNLDYEVERERAIRSCLDRNPSAFKPKITAPNSGDMR 810
                    |||||::|:||..|:|    |||.:|:||.:||::||||||.||:||:.....|..:
Mouse   278 --------YCDCFSSGDFCNSCSC----NNLRHELERFKAIKACLDRNPEAFQPKMGKGRLGAAK 330

  Fly   811 L-HNKGCNCKRSGCLKNYCECYEAKIPCSSICKCVGCRNMEDRPD-------------VDMDSLD 861
            | |:||||||||||||||||||||||.|||||||:.|:|.|:.|:             .|.:|..
Mouse   331 LRHSKGCNCKRSGCLKNYCECYEAKIMCSSICKCIACKNYEESPERKMLMSTPHYMEPGDFESSH 395

  Fly   862 GLMGVEGQKKDK-AKNKQLNENRANIYFTDDVIEATIMCMISRIVMHEKQNVAVEDMEREVMEEM 925
            .|...:.....| .||:|     |....:.:|:|||..|::::....|:::.:....|:.::||.
Mouse   396 YLSPAKFSGPPKLRKNRQ-----AFSCISWEVVEATCACLLAQGEEAEQEHCSPSLAEQMILEEF 455

  Fly   926 GESLTQII 933
            |..|:||:
Mouse   456 GRCLSQIL 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mip120	NP_001163143.1	TCR	740..775	CDD:281618	10/34 (29%)
mip120	NP_001163143.1	TCR	813..850	CDD:281618	31/36 (86%)
Tesmin	NP_001034746.1	TCR	334..371	CDD:281618	31/36 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846075
Domainoid	1	1.000	82	1.000	Domainoid score	I8412
eggNOG	1	0.900	-	-		E1_KOG1171
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44354
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12446
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2613
SonicParanoid	1	1.000	-	-		X1765
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.830