DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mip120 and LIN54

DIOPT Version :9

Sequence 1:	NP_001163143.1	Gene:	mip120 / 36499	FlyBaseID:	FBgn0033846	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	NP_919258.2	Gene:	LIN54 / 132660	HGNCID:	25397	Length:	749	Species:	Homo sapiens

Alignment Length:	987	Identity:	266/987 - (26%)
Similarity:	371/987 - (37%)	Gaps:	319/987 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LPE--------LSFEDFLEPTSEKSSQHMEIEALDSEEDNIGGEDLADPAND------SLNTPQF 69
            |||        |..:|.:|.....|...||.|..:....|..|:..|.|.:.      |.:|.|.
Human    12 LPEEIMDTGITLVDDDSIEAVIVSSPIPMETELEEIVNINSTGDSTATPISTEPITVYSNHTNQV 76

  Fly    70 KKNVVHILEDKRLNSSGLTVLKSHAIKMVTAGGTPPAKAQVTDVKILNKLKPIPSSTLKIGSTTI 134
            ..|......|     |..||..:....:...|...|.......: ||||:.  .:|.||:|:.|:
Human    77 AVNTTITKAD-----SNTTVKPAFPSGLQKLGAQTPVTISANQI-ILNKVS--QTSDLKLGNQTL 133

  Fly   135 ATKSTPGSITKTLGNLTQIRTKDGQVIFV---QKSVPGTQSSTAVTGSPSGGIRRLVAPSGIQKA 196
            ........:| |||       |.|..|.:   ...:|..|..|  |.:.||..:  :.|..|
Human   134 KPDGQKLILT-TLG-------KSGSPIVLALPHSQLPQAQKVT--TQAQSGDAK--LPPQQI--- 183

  Fly   197 VLSKGVTMASTGLVKAAVPAKASTSVPGSAITLKGIQPLAGGTAKASTSSTTATTSPSLAQPNKI 261
               |.||:.....||..:...|.|  |||.:                   ...||.||:.|..::
Human   184 ---KVVTIGGRPEVKPVIGVSALT--PGSQL-------------------INTTTQPSVLQTQQL 224

  Fly   262 QVVRTA-------DGKII-KINQAGPSLLVNAKQGTGTTVTPGGSAATSVKLSPSTGNVVLNKPV 318
            :.|:.|       .|.:| |:..|.|   :|:|..||.|        |.|......|.|:.....
Human   225 KTVQIAKKPRTPTSGPVITKLIFAKP---INSKAVTGQT--------TQVSPPVIAGRVLSQSTP 278

  Fly   319 GQVVVRTETPVKTAT--------GSVASASATPGKMLVQSGGKQILVSNKNIIKLSPNASATSST 375
            |       ||.||.|        .::.|.:.||.|:.:..            :| |||.:..|:.
Human   279 G-------TPSKTITISESGVIGSTLNSTTQTPNKIAISP------------LK-SPNKAVKSTV 323

  Fly   376 -THTTGGQTPS---------TSSGLHAIQLPGKGGIQYVRVLNNNKSAAGTSATASIPKTVQTQK 430
             |.|.||.:.|         |:..:..||:|| ....|||::....:::.|...:..|.| .||
Human   324 QTITVGGVSTSQFKTIIPLATAPNVQQIQVPG-SKFHYVRLVTATSASSSTQPVSQNPST-NTQ- 385

  Fly   431 ITVVRPPAATGVPATSTTTSAAAASPAAASKANLAMGNTNKIVMRSMGGSIVPLPSVQTLVSKRA 495
                  |.....|....||....:.|..:::|               ...:||.|...|
Human   386 ------PLQQAKPVVVNTTPVRMSVPIVSAQA---------------VKQVVPKPINPT------ 423

  Fly   496 LGAISNASKPASAASSSATPSASQELPR-KHRLTDLNVQLKQSASVSSEASDSSDAGPEAKKPRY 559
             ..|...|:|.......|||     ||: :..||:|     ...:|.:.|..:.:.|......:|
Human   424 -SQIVTTSQPQQRLIMPATP-----LPQIQPNLTNL-----PPGTVLAPAPGTGNVGYAVLPAQY 477

  Fly   560 VITMQQGSQKAASQPVQKLINRTANVQRVVSSSTSPSSNSTKKIYNYVQPTGSNGAKYMICNSGV 624
            |..:||                        ||..|.:||||.        ||::|
Human   478 VTQLQQ------------------------SSYVSIASNSTF--------TGTSG---------- 500

  Fly   625 PQSSTSAMRRGYTGYVENKTRRPPPISPQQHRFKQMGPQQQSKHQQLQAQAKQRIRQQQLPTEQS 689
                                                          :|.||:       ||
Human   501 ----------------------------------------------IQTQAR-------LP---- 508

  Fly   690 TPIKVEPKLPTLPPGVKANVPAKPLFEVLKPPATAAAAGAVDPLGGMTSRRKHCNCSKSQCLKLY 754
                    ...:.|...|:.|.||                             |||:||.|||||
Human   509 --------FNGIIPSESASRPRKP-----------------------------CNCTKSLCLKLY 536

  Fly   755 CDCFANGEFCQDCTCKDCFNNLDYEVERERAIRSCLDRNPSAFKPKITAPNSGDM-RLHNKGCNC 818
            ||||||||||.:|.|.:|:|||::|.||::||::||||||.||||||.....|:. |.|:|||||
Human   537 CDCFANGEFCNNCNCTNCYNNLEHENERQKAIKACLDRNPEAFKPKIGKGKEGESDRRHSKGCNC 601

  Fly   819 KRSGCLKNYCECYEAKIPCSSICKCVGCRNMEDRPD-VDMDSLDGLMGVEGQKKDKAKNK----- 877
            |||||||||||||||||.|||||||:||:|.|:.|: ..:..|.....|..|::..||.|
Human   602 KRSGCLKNYCECYEAKIMCSSICKCIGCKNFEESPERKTLMHLADAAEVRVQQQTAAKTKLSSQI 666

  Fly   878 ---------QLNENRANIYF---TDDVIEATIMCMISRIVMHEKQNVAVEDMEREVMEEMGESLT 930
                     .||.....:.|   |.:|.|||..|::::....:|:..:....||.::||.|..|.
Human   667 SDLLTRPTPALNSGGGKLPFTFVTKEVAEATCNCLLAQAEQADKKGKSKAAAERMILEEFGRCLM 731

  Fly   931 QIIAFA-KEKQE 941
            .:|..| |.|.:
Human   732 SVINSAGKAKSD 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mip120	NP_001163143.1	TCR	740..775	CDD:281618	23/34 (68%)
mip120	NP_001163143.1	TCR	813..850	CDD:281618	32/36 (89%)
LIN54	NP_919258.2	Atrophin-1	211..>461	CDD:397323	76/321 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	369..388		6/26 (23%)
		TCR	522..>545	CDD:397618	19/51 (37%)
		DNA-binding. /evidence=ECO:0000269\|PubMed:27465258	523..536		10/41 (24%)
		Linker. /evidence=ECO:0000269\|PubMed:27465258	583..596		3/12 (25%)
		TCR	596..631	CDD:397618	31/34 (91%)
		DNA-binding. /evidence=ECO:0000269\|PubMed:27465258	599..612		12/12 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	1.000	Domainoid score	I8420
eggNOG	1	0.900	-	-		E1_KOG1171
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	225	1.000	Inparanoid score	I3513
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003047
OrthoInspector	1	1.000	-	-		otm42302
orthoMCL	1	0.900	-	-		OOG6_106892
Panther	1	1.100	-	-	LDO	PTHR12446
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2613
SonicParanoid	1	1.000	-	-		X1765
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.850