DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rnf150 and APE3

DIOPT Version :9

Sequence 1:	NP_001178022.1	Gene:	Rnf150 / 364983	RGDID:	1304572	Length:	437	Species:	Rattus norvegicus
Sequence 2:	NP_009845.2	Gene:	APE3 / 852589	SGDID:	S000000490	Length:	537	Species:	Saccharomyces cerevisiae

Alignment Length:	176	Identity:	38/176 - (21%)
Similarity:	73/176 - (41%)	Gaps:	17/176 - (9%)

- Green bases have known domain annotations that are detailed below.

  Rat    35 EKEEWYTAFVNITYTEPESGAAVAGGGGGAELHTEKSECGRYGEHSPKQDARGEVVMASSVHDRL 99
            :.:::|.  |::...|..||..::.....||.....:....:....|.....|::|...:    |
Yeast   127 DMQDYYD--VSLQEFEALSGKIISFNLSDAETGKSFANTTAFALSPPVDGFVGKLVEIPN----L 185

  Rat   100 ACDPN--TKFAAPAHGKHWIALIPKGNCTYRDKIRNAFLQNASAVVIFNVGSNTNETI--TMPHA 160
            .|:..  .....|.|.:..||||.:|.|.:.||...|.....:||||::....:.|.:  |:...
Yeast   186 GCEEKDYASVVPPRHNEKQIALIERGKCPFGDKSNLAGKFGFTAVVIYDNEPKSKEGLHGTLGEP 250

  Rat   161 GVEDIVAIMIPEPKGKELVSLLERNVTVTMYIT-------IGTRNL 199
            ....:..:.:|...||:|::.:..|:..::|..       |.|:|:
Yeast   251 TKHTVATVGVPYKVGKKLIANIALNIDYSLYFAMDSYVEFIKTQNI 296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rnf150	NP_001178022.1	PA_GRAIL_like	45..192	CDD:239037	32/150 (21%)
		UPF0233	<206..>231	CDD:299753
		zf-RING_2	275..318	CDD:290367
APE3	NP_009845.2	M28_SGAP_like	78..506	CDD:349873	38/176 (22%)
APE3	NP_009845.2	PA_ScAPY_like	155..284	CDD:239045	29/132 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000832
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910