Protein Alignment mars and DLGAP5

DIOPT Version :10

• Sequence 1: NP_610878.1
• Gene: mars / 36498
• FlyBaseID: FBgn0033845
• Length: 921
• Species: Drosophila melanogaster
• Sequence 2: NP_055565.3
• Gene: DLGAP5 / 9787
• HGNCID: 16864
• Length: 846
• Species: Homo sapiens
• Alignment Length: 904
• Identity: 204/904 - (22%)
• Similarity: 325/904 - (35%)
• Gaps: 281/904 - (31%)

  Fly    77 PERLDTKPAELLKESNPKV---SRQKLYLQRYMEWK-IAKTKEHKQQDQKRRGAAINVPTVKQSK 137
            ||:.:.||..:      |.   .::|..||:|.|.| :.|.||  |:::.:||
Human    72 PEKTNVKPRAM------KTILGDQRKQMLQKYKEEKQLQKLKE--QREKAKRG------------ 116

  Fly   138 ALPKSQTFRVPDNLASAKQKEAAPMFQPPKRCSLYMIANPTGKGKAAEPIKPSIPKPTSAAAPPS 202
                  .|:|             ..::|...|  ::::|.  ....|||.|          |.||
Human   117 ------IFKV-------------GRYRPDMPC--FLLSNQ--NAVKAEPKK----------AIPS 148

  Fly   203 SNTVAASSALARHKSAASATKIVPAIRQNNNPVALARQKAAARPIPNTTKQTTSVRQPGIEAKKI 267
            |..:..|.|    |.....|||     .|.:.|      .|.||.|    :.||.::...:.||:
Human   149 SVRITRSKA----KDQMEQTKI-----DNESDV------RAIRPGP----RQTSEKKVSDKEKKV 194

  Fly   268 TTTIPRPTPATVTKAKTPGIRQQPPVVSTKPRLPEPPAPRTARLPNVLSKPFEKPLGNKAPVTRR 332
            ...: .||...:|::.|...:|.|..||:          .|||                .||||.
Human   195 VQPV-MPTSLRMTRSATQAAKQVPRTVSS----------TTAR----------------KPVTRA 232

  Fly   333 ANVVKPQ---PIRGGGGAAAKFKDTAGATSKAASHSIRMKATKIKSQYTRLQDNVRKLPQLKAEL 394
            ||..:|:   |.:|......:.|...|.:.|..|
Human   233 ANENEPEGKVPSKGRPAKNVETKPDKGISCKVDS------------------------------- 266

  Fly   395 LHAATLDIPPLTPLDDIHNPFIDQATSTQCKSNNSSGHLLEAFGDTILLSPVAPVKAEGESSVKR 459
                                   :..:...::|.:||           ::|      :|..| |.
Human   267 -----------------------EENTLNSQTNATSG-----------MNP------DGVLS-KM 290

  Fly   460 QLLPE---GKKEASGPVAKKKFDF------TRYSV-------ANSPAEDSLILDPQQTTVKEDTG 508
            :.|||   .|.:.....|.|.|.|      ..|.|       ||:....|....|.:|.|.|...
Human   291 ENLPEINTAKIKGKNSFAPKDFMFQPLDGLKTYQVTPMTPRSANAFLTPSYTWTPLKTEVDESQA 355

  Fly   509 DSTLVPEGTKT----PPRRESNGMPNYLSPFVSVSRGKVNSRCEKEKRNSFYLSNEESP-LE--- 565
            ...::.:..||    ..:::||.:|..|.|........|.::.|...:|...|..:|.| ||
Human   356 TKEILAQKCKTYSTKTIQQDSNKLPCPLGPLTVWHEEHVLNKNEATTKNLNGLPIKEVPSLERNE 420

  Fly   566 --VRRAIESVLYFRLQLENEITRLQALCAEWEAYSKENEARLQETGGIDMINVTIGQTRLLTTKK 628
              :.:....|.|||..|::|..:|.:.|.||:   ::.|..:.:... |:|...:||||||..::
Human   421 GRIAQPHHGVPYFRNILQSETEKLTSHCFEWD---RKLELDIPDDAK-DLIRTAVGQTRLLMKER 481

  Fly   629 MMQFSGLIDRCEAGATGKNSQPNDGSEDSKPVQAEDLEGWWDMLRLQSENVDKRFDNLKR----- 688
            ..||.||:|.||.            ....|.....||:|:|||:..|.|:|..:|:||.:
Human   482 FKQFEGLVDDCEY------------KRGIKETTCTDLDGFWDMVSFQIEDVIHKFNNLIKLEESG 534

  Fly   689 WKANDWLDPD------------AVAEEPKQPKPKPKISRN--MKIKSKAKPSSNLQQFLRKAHAN 739
            |:.|:.::.:            .:|.:|||.......:||  ..||:..:.....::....|.:.
Human   535 WQVNNNMNHNMNKNVFRKKVVSGIASKPKQDDAGRIAARNRLAAIKNAMRERIRQEECAETAVSV 599

  Fly   740 MKKT-----------KVEEPT-LEDGLPATSSRHSSPRVIVVRNRRSFSPARTVLRMSTGEGRQS 792
            :.|.           :||.|. |..|| :.||...|.|   :...:|.:.|.:..|...|..:|:
Human   600 IPKEVDKIVFDAGFFRVESPVKLFSGL-SVSSEGPSQR---LGTPKSVNKAVSQSRNEMGIPQQT 660

  Fly   793 IAPNALLKSAILAAAEQN-----AAKT---PPPKPRTSI--LKTPGTTK--RQNRGVLFSAKK-- 843
            .:|.        .|..||     ..||   ..|:.|:||  .:.||...  .:|..|..:..|
Human   661 TSPE--------NAGPQNTKSEHVKKTLFLSIPESRSSIEDAQCPGLPDLIEENHVVNKTDLKVD 717

  Fly   844 --SVRRFQFTYEEGNISND-ETVGADKLEDCEEDMSLEAS-TESGSLEQNPGRDSNQEN 898
              |..|.......|.:::| .|...:.:.|..|.|.|.:| |....|..:|.:::..:|
Human   718 CLSSERMSLPLLAGGVADDINTNKKEGISDVVEGMELNSSITSQDVLMSSPEKNTASQN 776

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mars	NP_610878.1	PHA03247	<131..342	CDD:223021	48/213 (23%)
		GKAP	<580..>694	CDD:460897	37/118 (31%)
DLGAP5	NP_055565.3	PspC_subgroup_1	<24..>196	CDD:468201	46/195 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	153..284		44/247 (18%)
		GKAP	<414..601	CDD:460897	53/202 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	628..674		13/56 (23%)