Protein Alignment mars and DLGAP1

DIOPT Version :10

• Sequence 1: NP_610878.1
• Gene: mars / 36498
• FlyBaseID: FBgn0033845
• Length: 921
• Species: Drosophila melanogaster
• Sequence 2: NP_001385454.1
• Gene: DLGAP1 / 9229
• HGNCID: 2905
• Length: 987
• Species: Homo sapiens
• Alignment Length: 857
• Identity: 164/857 - (19%)
• Similarity: 295/857 - (34%)
• Gaps: 252/857 - (29%)

  Fly     1 MQRHKELYK------EQSLVLSPRNHCQENR---------DRLQAARAKKREDCFYQNRIIS--- 47
            :.|.:|:|:      :|::|.|  ..||:.|         |.......:.::|.....|:.|
Human   285 VSRAREVYQKASVNMDQAMVKS--ESCQQERSCQYLQVPQDEWTGYTPRGKDDEIPCRRMRSGSY 347

  Fly    48 -------------VSPTPVKIKQLAAAQAALTQENVAPKLESPERLDTKPAELLKESNPKVS-RQ 98
                         .||.|       :.:.|..:|:.. |...|...:....::..|.:||:. |.
Human   348 IKAMGDEDSGDSDTSPKP-------SPKVAARRESYL-KATQPSLTELTTLKISNEHSPKLQIRS 404

  Fly    99 KLYLQRYMEWKIAKTKEHKQQDQKRRGAAINVPTVKQSKALPKSQTF-RVPDNLASAKQKEAAPM 162
            ..||:...|..|     ::..|.......:..|     |...::::: |....::...:.|....
Human   405 HSYLRAVSEVSI-----NRSLDSLDPAGLLTSP-----KFRSRNESYMRAMSTISQVSEMEVNGQ 459

  Fly   163 FQPPKRCSLYMIANPTGKGKAAEPIKPSIPKPTSAAAPPSSNTVAASSALARHKSAASATKIVPA 227
            |:     |:........:.:|.|.:  .:|.|                ...|.:|.:....|...
Human   460 FE-----SVCESVFSELESQAVEAL--DLPMP----------------GCFRMRSHSYVRAIEKG 501

  Fly   228 IRQNNNPVALARQKAAARPIPNTTKQTTSVR--QPGIEAKKITTTIPRPTPATVTKAKTPGIRQQ 290
            ..|::..|:|   ::::.|     :.||:||  |......|:::.:...:..|..| |||
Human   502 CSQDDECVSL---RSSSPP-----RTTTTVRTIQSSTGVIKLSSAVEVSSCITTYK-KTP----- 552

  Fly   291 PPVVSTKPRLPEPPAPRTARLPNVLSKPFEKPLGNKAPVTRRANVVKPQPIRGGGGAAAKFKDTA 355
                        ||.|     |...:|||       ..:|.:::....|.         .:.|..
Human   553 ------------PPVP-----PRTTTKPF-------ISITAQSSTESAQD---------AYMDGQ 584

  Fly   356 GATSKAASHSIRMKATKIKSQYTRLQDNVRKLPQLKA--ELLHAATLDIPPLTPLDDIHNPFIDQ 418
            |......|.|             .|.::...|..:||  ..:.||..         .||.|
Human   585 GQRGDIISQS-------------GLSNSTESLDSMKALTAAIEAANA---------QIHGP---- 623

  Fly   419 ATSTQCKSNNSSGHLLEAFGDTILLSPVAPVKAEGESSVKRQLLPEG------------------ 465
              ::|...||::     ....|..::.|.....:.:...|.:.|..|
Human   624 --ASQHMGNNTA-----TVTTTTTIATVTTEDRKKDHFKKNRCLSIGIQVDDAEEPDKTGENKAP 681

  Fly   466 -KKEASGPVAKKKFDFTRYSVANS--------------------PAEDSLILDPQQTTVKEDTGD 509
             |.::.|...:::..|.|::.:||                    ..||:....|.......|...
Human   682 SKFQSVGVQVEEEKCFRRFTRSNSVTTAVQADLDFHDNLENSLESIEDNSCPGPMARQFSRDAST 746

  Fly   510 STLVPEGT-------KTPPRRESNGMPNYLSPFVSVSRGKVNSRCEKEKRNSFYLSNEESPLE-V 566
            ||:..:|:       ......:::..|:.|.|                 .:.:..|..|.||| |
Human   747 STVSIQGSGNHYHACAADDDFDTDFDPSILPP-----------------PDPWIDSITEDPLEAV 794

  Fly   567 RRAI--ESVLYFRLQLENEITRLQALCAEWEAYSKENEARLQETGGIDMINVTIGQTRLLTTKKM 629
            :|::  ....:|...|:.|..|::..|.:.|...:||.......|   .|...:|..:||..:|.
Human   795 QRSVCHRDGHWFLKLLQAERDRMEGWCQQMEREERENNLPEDILG---KIRTAVGSAQLLMAQKF 856

  Fly   630 MQFSGLIDRCEAGATGKNSQPNDGSEDSKPVQAEDLEGWWDMLRLQSENVDKRFDNLKRWKANDW 694
            .||..|   ||     :|..||   ...:|. ::||.|:||||:|..||:..:||.|.:.|||:|
Human   857 YQFREL---CE-----ENLNPN---AHPRPT-SQDLAGFWDMLQLSIENISMKFDELHQLKANNW 909

  Fly   695 LDPDAV-AEEPKQPKPKPK--------ISRNMKIKSKAKPSSNLQQFLRKAHANMKKTKVEE--P 748
            ...|.: .:|.:.|.|.||        :.|...::|..:..:..:....|..|::::....|  .
Human   910 KQMDPLDKKERRAPPPVPKKPAKGPAPLIRERSLESSQRQEARKRLMAAKRAASVRQNSATESAE 974

  Fly   749 TLEDGLPATSSR 760
            ::|..:|...:|
Human   975 SIEIYIPEAQTR 986

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mars	NP_610878.1	PHA03247	<131..342	CDD:223021	37/213 (17%)
		GKAP	<580..>694	CDD:460897	38/113 (34%)
DLGAP1	NP_001385454.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	150..203
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	349..371		3/28 (11%)
		GKAP	655..987	CDD:460897	80/364 (22%)
		Interaction with DYL2. /evidence=ECO:0000250	660..671		2/10 (20%)
		Interaction with DYL2. /evidence=ECO:0000250	682..693		2/10 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	909..975		12/65 (18%)
		PDZ-binding. /evidence=ECO:0000250	985..987		1/2 (50%)