Protein Alignment mars and DLGAP2

DIOPT Version :10

• Sequence 1: NP_610878.1
• Gene: mars / 36498
• FlyBaseID: FBgn0033845
• Length: 921
• Species: Drosophila melanogaster
• Sequence 2: NP_001333739.1
• Gene: DLGAP2 / 9228
• HGNCID: 2906
• Length: 1055
• Species: Homo sapiens
• Alignment Length: 985
• Identity: 202/985 - (20%)
• Similarity: 319/985 - (32%)
• Gaps: 333/985 - (33%)

  Fly    17 PRNHCQENRDRLQAARAKKREDCFYQNRIISVSPTPVKI-----KQL-----------------A 59
            ||.|...:.|        .|:||...:....::..|..:     |||                 |
Human   162 PRMHYSSHYD--------TRDDCAVAHAGAKINRIPANLLDQFEKQLPLHRDGFHTLQYQRTSAA 218

  Fly    60 AAQAALTQENVAPKLESPERLDTKPAELLKESNPKVSRQKL--------YLQRYMEWKIAKTKEH 116
            |.|.:.:...:...:.|.::|.||...|...|....:..|.        :.......|.:|:||.
Human   219 AEQRSESPGRIRHLVHSVQKLFTKSHSLEGSSKSNANGTKADGRADDHHHAHHAKHSKRSKSKER 283

  Fly   117 KQQDQKRRG--------------AAINVPTVKQSKAL-PKSQTFRVPDNLAS------------- 153
            |.:.:.|.|              :....|:|.....| |.:..:  ||.|.|
Human   284 KPEGKPRPGMSSWWSSDDNLDSDSTYRTPSVLNRHHLGPVAHCY--PDALQSPFGDLSLKTSKSN 346

  Fly   154 --------------------------------AKQ---------------KEAAPMFQPPKRCSL 171
                                            ||:               ::|.|..:|   |..
Human   347 NDVKCSACEGLALTPDAKYLKRSSWSTLTVSQAKEAYRKSSLNLDKPLLHQDAKPALRP---CHY 408

  Fly   172 YMIAN------PTGKGKAAE-PIK-------------------PSIPK--PTSAAAPPSSNTVAA 208
            ..:..      ||| ||..| |.:                   .|.||  |.||..|........
Human   409 LQVPQDEWGGYPTG-GKDEEIPCRRMRSGSYIKAMGDEESGESDSSPKTSPKSAILPEPLLKSIG 472

  Fly   209 SSALARHKS-----AAS----ATKIVPAIRQNNNPVALARQKAAARPIPNTTKQTTSVRQ----- 259
            ...|..|::     |||    ...:.||... |:|...:|.::..|.: :|..|.:.|.|
Human   473 QRPLGEHQTQTYLQAASDVPVGHSLDPAANY-NSPKFRSRNQSYMRAV-STLSQASCVSQVSEAE 535

  Fly   260 --------------------------PG------------IEA--KKITTTIPRPTPATVTKAKT 284
                                      ||            |:|  .:....||..||:.:|..
Human   536 INGQFESVCESVFSEVESQAMDALDLPGCFRTRSHSYLRAIQAGYSQDDECIPMMTPSDITST-- 598

  Fly   285 PGIRQQPPVVSTKPRLPEPPAPRTARLPNVLSKPFEKPLGNKAPVT-------RRANVVKPQPIR 342
              ||....|..|..:...||.|     |...|||........:..:       .||..:.|.|
Human   599 --IRSTAAVSYTNYKKTPPPVP-----PRTTSKPLISVTAQSSTESTQDAYQDSRAQRMSPWP-- 654

  Fly   343 GGGGAAAKFKDTAGA--------TSKAASHSIRMKATK---IKSQYTRLQDNVRKLPQLKA-ELL 395
                     :|:.|.        ::||.:.::...|.:   .:||.:.::.:.:.:...|| |||
Human   655 ---------QDSRGLYNSTDSLDSNKAMNLALETAAAQRHLPESQSSSVRTSDKAILVSKAEELL 710

  Fly   396 HAATLDIPPLTPLDDIHNPFIDQATSTQCKSNNSSGHLLEAFGDTILL-------------SPVA 447
            .:....|.........|.|:......|...|:..|..|.|.....:.:             |..|
Human   711 KSRCSSIGIQDSEFPEHQPYPRSDVETATDSDTESRGLREYHSVGVQVEDEKRHGRFKRSNSVTA 775

  Fly   448 PVKAEGE-SSVKRQLLPEGKKEASGPVAKKKFDFTRYSVANSPAEDSLILDPQQT---TVKEDTG 508
            .|:|:.| ......:..|.|....|.      .|.|:|..::|.:.|.:...:..   :.:||.
Human   776 AVQADLELEGFPGHITTEDKGLQFGS------SFQRHSEPSTPTQYSAVRTVRTQGLFSYREDY- 833

  Fly   509 DSTLVPEGTKTPPRRESNGMPNYLSPFV-SVSRGKVNSRCEKEKRNSFYLSNEESPLEVRRAIES 572
             .|.|...|..||       ..:|.|.: :|..|:: |.|.::  .|::|.
Human   834 -RTQVDTSTLPPP-------DPWLEPAIDTVETGRM-SPCRRD--GSWFLK-------------- 873

  Fly   573 VLYFRLQLENEITRLQALCAEWEAYSKENEARLQETGGIDMINVTIGQTRLLTTKKMMQFSGLID 637
                  .|..|..|::..|.|.|..::||:...:..|   .|...:|..:||.::|..||..|
Human   874 ------LLHAETKRMEGWCKEMEREAEENDLSEEILG---KIRSAVGSAQLLMSQKFQQFYWL-- 927

  Fly   638 RCEAGATGKNSQPNDGSEDSKPVQAEDLEGWWDMLRLQSENVDKRFDNLKRWKANDW--LDPDAV 700
             |:        |..|.|...:|. ::||.|:||||:|..|:|..:||.|:|.:.|||  ::....
Human   928 -CQ--------QNMDPSAMPRPT-SQDLAGYWDMLQLSIEDVSMKFDELQRLRLNDWKMMESPER 982

  Fly   701 AEEPKQPKPKPK--------ISRNMKIKSKAKPSSNLQQFLR-----KAHANMKKTKVEE--PTL 750
            .||.|.|.|.||        |:|.   ||...|....|:..|     |..|:.::....|  .::
Human   983 KEERKVPPPIPKKPPKGKFPITRE---KSLDLPDRQRQEARRRLMAAKRAASFRQNSASERADSI 1044

  Fly   751 EDGLPATSSR 760
            |..:|...:|
Human  1045 EIYIPEAQTR 1054

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mars	NP_610878.1	PHA03247	<131..342	CDD:223021	67/360 (19%)
		GKAP	<580..>694	CDD:460897	37/113 (33%)
DLGAP2	NP_001333739.1	GKAP	711..1055	CDD:460897	95/400 (24%)