Protein Alignment mars and Dlgap1

DIOPT Version :10

• Sequence 1: NP_610878.1
• Gene: mars / 36498
• FlyBaseID: FBgn0033845
• Length: 921
• Species: Drosophila melanogaster
• Sequence 2: NP_075235.3
• Gene: Dlgap1 / 65040
• RGDID: 620223
• Length: 992
• Species: Rattus norvegicus
• Alignment Length: 845
• Identity: 164/845 - (19%)
• Similarity: 292/845 - (34%)
• Gaps: 229/845 - (27%)

  Fly     1 MQRHKELYK------EQSLVLSPRNHCQENR---------DRLQAARAKKREDCFYQNRIIS--- 47
            :.|.:|:|:      :|::|.|  ..||:.|         |.......:.::|.....|:.|
  Rat   291 VSRAREVYQKASVNMDQAVVKS--EACQQERSCQYLQVPQDEWTGYTPRGKDDEIPCRRMRSGSY 353

  Fly    48 -------------VSPTPVKIKQLAAAQAALTQENVAPKLESPERLDTKPAELLKESNPKVS-RQ 98
                         .||.|       :.:.|..:|:.. |...|...:....::..|.:||:. |.
  Rat   354 IKAMGDEDSGDSDTSPKP-------SPKVAARRESYL-KATQPSLTELTTLKISNEHSPKLQIRS 410

  Fly    99 KLYLQRYMEWKIAKTKEHKQQDQKRRGAAINVPTVKQSKALPKSQTF-RVPDNLASAKQKEAAPM 162
            ..||:...|..|     ::..|.......:..|     |...::::: |....::...:.|....
  Rat   411 HSYLRAVSEVSI-----NRSLDSLDPAGLLTSP-----KFRSRNESYMRAMSTISQVSEMEVNGQ 465

  Fly   163 FQPPKRCSLYMIANPTGKGKAAEPIKPSIPKPTSAAAPPSSNTVAASSALARHKSAASATKIVPA 227
            |:     |:........:.:|.|.:  .:|.|                ...|.:|.:....|...
  Rat   466 FE-----SVCESVFSELESQAVEAL--DLPMP----------------GCFRMRSHSYVRAIEKG 507

  Fly   228 IRQNNNPVALARQKAAARPIPNTTKQTTSVR--QPGIEAKKITTTIPRPTPATVTKAKTPGIRQQ 290
            ..|::..|:|   ::::.|     :.||:||  |......|:::.:...:..|..| |||
  Rat   508 CSQDDECVSL---RSSSPP-----RTTTTVRTIQSSTGVIKLSSAVEVSSCITTYK-KTP----- 558

  Fly   291 PPVVSTKPRLPEPPAPRTARLPNVLSKPFEKPLGNKAPVTRRANVVKPQPIRGGGGAAAKFKDTA 355
                        ||.|     |...:|||       ..:|.:::....|.         .:.|..
  Rat   559 ------------PPVP-----PRTTTKPF-------ISITAQSSTESAQD---------AYMDGQ 590

  Fly   356 GATSKAASHSIRMKATKIKSQYTRLQDNVRKLPQLKA--ELLHAATLDIPPLTPLDDIHNPFIDQ 418
            |......|.|             .|.::...|..:||  ..:.||..         .||.|....
  Rat   591 GQRGDMISQS-------------GLSNSTESLDSMKALTAAIEAANA---------QIHGPASQH 633

  Fly   419 -------ATSTQCKSNNSSGHLLEAFGDTILLSPVAPVKAEGESSVKRQLLPEGKKEASGPVAKK 476
                   .|:|...:..::....:.|.....||....|....||....:.....|.::.|...::
  Rat   634 MGSNAAAVTTTTTIATVTTEDRKKDFKKNRCLSIGIQVDDAEESEKMAESKTSSKFQSVGVQVEE 698

  Fly   477 KFDFTRYSVANS--------------------PAEDSLILDPQQTTVKEDTGDSTLVPEGT---- 517
            :..|.|::.:||                    ..||:....|.......|...||:..:|:
  Rat   699 EKCFRRFTRSNSVTTAVQADLDFHDNLENSLESIEDNSCPGPMARQFSRDASTSTVSIQGSGNHY 763

  Fly   518 ---KTPPRRESNGMPNYLSPFVSVSRGKVNSRCEKEKRNSFYLSNEESPLE-VRRAI--ESVLYF 576
               ......:::..|:.|.|                 .:.:..|..|.||| |:|::  ....:|
  Rat   764 HACAADDDFDTDFDPSILPP-----------------PDPWIDSITEDPLEAVQRSVCHRDGHWF 811

  Fly   577 RLQLENEITRLQALCAEWEAYSKENEARLQETGGIDMINVTIGQTRLLTTKKMMQFSGLIDRCEA 641
            ...|:.|..|::..|.:.|...:||.......|   .|...:|..:||..:|..||..|   ||
  Rat   812 LKLLQAERDRMEGWCKQMEREERENNLPEDILG---KIRTAVGSAQLLMAQKFYQFREL---CE- 869

  Fly   642 GATGKNSQPNDGSEDSKPVQAEDLEGWWDMLRLQSENVDKRFDNLKRWKANDWLDPDAV-AEEPK 705
                :|..||   ...:|. ::||.|:||||:|..||:..:||.|.:.|||:|...|.: .:|.:
  Rat   870 ----ENLNPN---AHPRPT-SQDLAGFWDMLQLSIENISMKFDELHQLKANNWKQMDPLDKKERR 926

  Fly   706 QPKPKPK--------ISRNMKIKSKAKPSSNLQQFLRKAHANMKKTKVEE--PTLEDGLPATSSR 760
            .|.|.||        :.|...::|..:..:..:....|..|::::....|  .::|..:|...:|
  Rat   927 APPPVPKKPAKGPAPLIRERSLESSQRQEARKRLMAAKRAASVRQNSATESAESIEIYIPEAQTR 991

  Fly   761  760
              Rat   992  991

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mars	NP_610878.1	PHA03247	<131..342	CDD:223021	37/213 (17%)
		GKAP	<580..>694	CDD:460897	38/113 (34%)
Dlgap1	NP_075235.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	154..209
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	355..375		3/26 (12%)
		GKAP	660..992	CDD:460897	82/364 (23%)
		Interaction with DYL2. /evidence=ECO:0000269|PubMed:14760703	665..676		3/10 (30%)
		Interaction with DYL2. /evidence=ECO:0000269|PubMed:14760703	687..698		2/10 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	914..980		12/65 (18%)
		PDZ-binding	990..992		1/2 (50%)