DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mars and dlgap5

DIOPT Version :9

Sequence 1:	NP_001163142.1	Gene:	mars / 36498	FlyBaseID:	FBgn0033845	Length:	921	Species:	Drosophila melanogaster
Sequence 2:	NP_001004592.1	Gene:	dlgap5 / 447853	ZFINID:	ZDB-GENE-040912-160	Length:	909	Species:	Danio rerio

Alignment Length:	1000	Identity:	222/1000 - (22%)
Similarity:	336/1000 - (33%)	Gaps:	337/1000 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RHKELYKEQS------LVLSPR--NHCQENRDRLQAARAKKREDCFYQNRIISVSPTPVKIKQLA 59
            |...|||..|      |.:|.|  ...:|||:::|..|.       :.:|:..:. ..:....|.
Zfish     4 RFAHLYKRDSSTSMIRLKMSRRRSQSQKENREKIQNMRR-------HLDRLPEID-LSMDTSTLM 60

  Fly    60 AAQAALTQENVAPKLESPERLDTKPAELLKESNPKVSRQKLYLQRYMEWKIAKTKEHKQQDQKRR 124
            |.|      :.|||        ||.|   .:|:.....:|..|.||.|.||.: ||.::::::::
Zfish    61 ATQ------DKAPK--------TKTA---SDSSDAAEERKKMLARYKENKILQ-KEKEKREKEKK 107

  Fly   125 GAAINVPTVKQSKALPKSQTFRVPDNLASAKQKEAAPMFQPPKRCSLYMIANPTGKGKAAEPIKP 189
            |                  .|:|                      .||
Zfish   108 G------------------VFKV----------------------GLY----------------- 115

  Fly   190 SIPKPTSAAAPPSSNTVAASSALARHKSAASATKIVPAIRQNNNPVALARQKAAARPIPNTTKQT 254
               ||......| |||.|...|.|...:  .:|::..::.||..   ||.::.|   :|...:..
Zfish   116 ---KPQPLGYLP-SNTAAPGRAKATEMN--QSTRMTRSMVQNQK---LAVERHA---VPKKVECL 168

  Fly   255 TSVRQPGIEAKKITTTIPRPTPATVTKAKTPGIRQQPPVVSTKPRLPEPPAPRTARLPNVLSKPF 319
            ::.|.|..|.:|       |..:|.|:|.|    .:|||.:...|    .|.:||  |:.:.||.
Zfish   169 STARAPAKENRK-------PLTSTKTRATT----AEPPVRAQTTR----SAAKTA--PDAVVKPV 216

  Fly   320 EKPLGNKAPVTRRANVVKPQPIRGGGGAAAKFKDTAGATSKAASHSIRMKATKIKSQYTRLQDNV 384
            ....|   |.||.|......|..|.|      |...|          .|||            ||
Zfish   217 ADTRG---PKTRSAVKYPAAPSSGRG------KVVQG----------NMKA------------NV 250

  Fly   385 RKLPQLKAELLHAAT--LDIPPLTPLDDIHNPFIDQATSTQCKSNNSSGHLLEAFGDTILLSPVA 447
            ...|   ||:...|.  ::.|...|.......|:.|....           |.:| :.:.|||
Zfish   251 ENKP---AEIKDTAVDKVEEPKAAPASFAPQGFVFQPPVG-----------LRSF-EPVPLSP-- 298

  Fly   448 PVKAEGESSVKRQLLPEGKKEASGPVAKKKFDFTRYSVANSPAEDSLILDPQQTTVKEDTGDSTL 512
                   ||....|.|....|                |:..||..|    |.:..|
Zfish   299 -------SSANAFLSPSFNSE----------------VSMEPAFPS----PPKPVV--------- 327

  Fly   513 VPEGTKTPPRRESNGMPNYLSPFVSVSRGKVNSRCEKEKRNSF-YLSNEESPLEVRRAIE---SV 573
               ...:||...|..||::     .:|...|:|..:.:   || ..|.:.:|.....::|   .|
Zfish   328 ---SFSSPPPSVSAHMPDH-----PISPPSVSSPLQAQ---SFPQPSTDAAPSPSSASMEPQHDV 381

  Fly   574 LYFRLQLENEITRLQALCAEWEAYSKENEARLQETGGIDMINVTIGQTRLLTTKKMMQFSGLIDR 638
            .|||..:.:|..||..|...||  |:.::|.:.|... |.:...:||.|||..::..||:||:|.
Zfish   382 AYFRAAMASETERLTGLSELWE--SRFDDASIPEEMR-DRMRTAVGQARLLMKERFGQFNGLVDD 443

  Fly   639 CEAGATGKNSQPNDGSEDSKPVQAEDLEGWWDMLRLQSENVDKRFDNLKRWKANDWLDPDAVAEE 703
            |            |.....|.....||:|:|||:..|.|:|:|:|..||..:|.||       :|
Zfish   444 C------------DFKRGEKITTCTDLQGFWDMVYFQVEDVNKKFSALKEAEARDW-------KE 489

  Fly   704 PKQPKPKPKISRNMKI---KSKAKPSSN---------LQQFLRKAHANMKKTKVEEPTLEDG--- 753
            ..:|..|.::.:...:   |:.|....|         ::..::...|..|.|:..:...||.
Zfish   490 EVKPVTKKRVVKKPPVVAGKAAAGGGGNAAAKSRLAAIKAAMKAKQAEQKATETSDKPQEDSSSV 554

  Fly   754 ----------------------LPATSSRH-----SSPRV----IVVRNRRS--FSPARTVLRMS 785
                                  .||...|.     |||.|    ..||..||  .|.|..:..||
Zfish   555 SVAPVQSVVFHGGFFQVESPVKTPAAVRRSCRGVVSSPSVTKFSTPVRQCRSTAISRASPLPCMS 619

  Fly   786 TGEGRQSIAPNALLKSAILAAAEQNAAKTPPPKPRTSILKTPGTTKRQNRGVLFSAKKSVRR--- 847
            |...| .:.|..|..|..|.:||........|:.....::.|.|....|....|.:..:..:
Zfish   620 TTPPR-PLQPEVLPISTPLRSAEPLPESPRAPQMTPDHMQAPHTDLCSNSQPQFDSSSTCTQQTQ 683

  Fly   848 ------------FQF-----------------------TYEEGNISNDETV----GADKLEDC-- 871
                        .||                       |..|.|:.::|::    ..|.|..|
Zfish   684 PDFRNEAENSPAGQFDCPVECSEAQIEDCIPESMLSPSTQAEDNVVSEESLHVSASVDALSQCSF 748

  Fly   872 -EEDMSLEASTESGSLEQNPGRDSN 895
             |.:.|:.|......:...|.:|.|
Zfish   749 HEAEPSVCAPASPAMMPSTPTKDLN 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mars	NP_001163142.1	GKAP	<558..>703	CDD:281368	46/147 (31%)
dlgap5	NP_001004592.1	GKAP	<360..505	CDD:281368	49/166 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577579
Domainoid	1	1.000	72	1.000	Domainoid score	I9315
eggNOG	1	0.900	-	-		E1_KOG3971
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	80	1.000	Inparanoid score	I5208
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007971
OrthoInspector	1	1.000	-	-		oto40725
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12353
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8319
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.920