DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mars and Dlgap4

DIOPT Version :9

Sequence 1:	NP_001163142.1	Gene:	mars / 36498	FlyBaseID:	FBgn0033845	Length:	921	Species:	Drosophila melanogaster
Sequence 2:	NP_775168.2	Gene:	Dlgap4 / 286930	RGDID:	708350	Length:	992	Species:	Rattus norvegicus

Alignment Length:	768	Identity:	161/768 - (20%)
Similarity:	257/768 - (33%)	Gaps:	229/768 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 SVSPTPVKIKQLAAAQAAL--TQENVAPKLESPERLDTKPAELLKESNPKVSRQKL------YLQ 103
            |..|:|   |..|..|:.|  ||:::.                 ::|||:.|..:|      ...
  Rat   384 SPKPSP---KTAARRQSYLRATQQSLG-----------------EQSNPRRSLDRLDSVDMPLPS 428

  Fly   104 RYMEWK-------------------------IAKTKEHKQQDQKRRGAAINVPTVKQSKALPKSQ 143
            :|..|:                         |.:...|   ||:.|.|.::    .|.:|..:|.
  Rat   429 KYPSWEEDYNPISDSLNDSGCISQVFGQASLIPQLFGH---DQQVREADLS----DQYEAACESA 486

  Fly   144 TFRVPDNLASAKQKEAAPMFQPPKRCSLYMIANPTGKGKAAEPIK-PSIPKPTSAAAPPSSNTVA 207
            ........|.|........|:  .|...|:.|...|..:..:.:. .|:..|.|..:..:|.|:.
  Rat   487 CSEAESTAAEALDLSLPSYFR--SRSHSYLRAIQAGCSQEEDSVSLQSLSPPPSTGSLSNSRTLP 549

  Fly   208 ASSALARHKSAASATKIVPAI--RQNNNPVALARQKAAARPIPNT-------TKQTTSVRQPGIE 263
            :||.|..:|      |..|.:  |..:.|......:::.....:|       ..:.||  |.|:.
  Rat   550 SSSCLVAYK------KTPPPVPPRTTSKPFISVTVQSSTESAQDTYLDSQDHKSEVTS--QSGLS 606

  Fly   264 AKKITTTIPRPTPATVTKAKTPGIRQQPPVVSTKPRLPEPPAPRTARLPNVLSKPFEKPLGNKAP 328
            ....:.......|:......|||           |..|||| |:.|.|
  Rat   607 NSSDSLDSSTRPPSVTRGGITPG-----------PEAPEPP-PKHAAL----------------- 642

  Fly   329 VTRRANVVKPQPIRGGGGAAAKFKDTAGATSKAASHSIRMKATKIKSQYTRLQDNVRKLPQLKAE 393
                                   |...|..:.:.|||..:...|:.|...:: |.::.:|:.:..
  Rat   643 -----------------------KSEHGTLTSSESHSEAVPKRKLSSIGIQV-DCIQPVPKEEPS 683

  Fly   394 LLHAATLDIPPLTPLDDIHNPFIDQATSTQCKSNNSSGHLLEAFGDTILLSPVAPVKAEGESSVK 458
                      |.|....|.....|...|      ::..|.:.:..||     .:..:...:||.|
  Rat   684 ----------PATKFQSIGVQVEDDWRS------SAPSHSMSSRRDT-----DSDTQDANDSSCK 727

  Fly   459 RQLLPEGKKEASGPVAKKKFDFTRY----SVANSPAEDSLILDPQQTTVKEDTGDSTLVPEGTKT 519
                   ..|.|.|      |.|.:    |:...|.:...|...::.....|..|..|  |.:..
  Rat   728 -------SSERSLP------DCTSHPNSISIDAGPRQAPKIAQIKRNLSYGDNSDPAL--EASSL 777

  Fly   520 PPRRESNGMPNYLSPFVSVSRGKVNSRCEKEKRNSFYLSNEESPLEVRRAIESVLYFRLQLENEI 584
            ||       |:   |::..|.                 |:...|.:.........:|...|:.|.
  Rat   778 PP-------PD---PWLETSS-----------------SSPAEPAQPGACRRDGYWFLKLLQAET 815

  Fly   585 TRLQALCAEWEAYSKENEARLQETGGIDMINVTIGQTRLLTTKKMMQFSGLIDRCEAGATGKNSQ 649
            .||:..|.:.:..:|||....:..|   .:...:|..:||.::|..||.||   ||     :|..
  Rat   816 ERLEGWCCQMDKETKENNLSEEVLG---KVLSAVGSAQLLMSQKFQQFRGL---CE-----QNLN 869

  Fly   650 PNDGSEDSKP-VQAEDLEGWWDMLRLQSENVDKRFDNLKRWKANDWL---DPDAVAEEPKQPKPK 710
            |     |:.| ..|:||.|:||:|:|..|::..:||.|...|||.|.   .|:...||.|.|.|.
  Rat   870 P-----DANPRPTAQDLAGFWDLLQLSIEDISMKFDELYHLKANSWQLVETPEKRKEEKKPPPPV 929

  Fly   711 PKISRNMKIKSKAKPSSNLQQFLRKAHANMKKTKVEEPTLEDGLPATSSRHSS 763
            ||    ...||||..|.:     :.:.|..|:.:.....|.....|.|.|.:|
  Rat   930 PK----KPAKSKAAVSRD-----KASDAGDKQRQEARKRLLAAKRAASVRQNS 973

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mars	NP_001163142.1	GKAP	<558..>703	CDD:281368	43/148 (29%)
Dlgap4	NP_775168.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..226
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	342..435		16/70 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	527..665		36/197 (18%)
		GKAP	660..992	CDD:397439	94/403 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	677..751		19/107 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	763..798		11/63 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	915..992		20/68 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3971
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12353
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910