DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mars and Dlgap3

DIOPT Version :9

Sequence 1:	NP_001163142.1	Gene:	mars / 36498	FlyBaseID:	FBgn0033845	Length:	921	Species:	Drosophila melanogaster
Sequence 2:	NP_775161.2	Gene:	Dlgap3 / 286923	RGDID:	708349	Length:	977	Species:	Rattus norvegicus

Alignment Length:	485	Identity:	112/485 - (23%)
Similarity:	182/485 - (37%)	Gaps:	124/485 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   338 PQPIRGGGGAAAKFKDTAGATSKAASHSIRMKATKIKSQYTRLQDNVRKLPQ---LKAELLHAAT 399
            |.||..|..|..:...||.:::.:|..|           :|..:...|:...   |....:.|.|
  Rat   539 PPPIPPGSQAPPRISITAQSSTDSAHES-----------FTAAEGPARRCSSADGLDGPTMGART 592

  Fly   400 LDIPPLTPLDDIHNPFID----------QATSTQCKSNNSSGHLLEAFGDTILLSPVAPVKAEGE 454
            |::.|:.|......|.:.          ::.:.|.|...|.|..:|...|           ::.|
  Rat   593 LELAPVPPRASPKPPTLIIKTIPGREELRSLARQRKWRPSIGVQVETISD-----------SDTE 646

  Fly   455 SSVKRQLLPEGKKEASGPVAKKKFDFTRYSVANSPAEDSLILDPQQTTVKEDTGDSTLVPEGTKT 519
            :..:|:....|.:....   |::..|.|.:...:..:..|.|:.........|.|..|  :..::
  Rat   647 NRSRREFHSIGVQVEED---KRRARFKRSNSVTAGVQADLELEGLAGLATVATEDKAL--QFGRS 706

  Fly   520 PPRRESNGMPNYLSPFVSVSR---------------------------------------GKVNS 545
            ..|..|...|...:|..||.|                                       |:.:|
  Rat   707 FQRHASEPQPGPRAPTYSVFRTVHTQGQWAYREGYPLPYEPPATDGSPGPPPVPAPGPGSGRRDS 771

  Fly   546 RCEKEKRNSFYLSNEESPLEVRRAIESVLYFRLQLENEITRLQALCAEWEAYSKENEARLQETGG 610
            ..|:..| |...|...||..  |..|   :|...|..|:.:|:..|.:.|..:::.|  |.|. .
  Rat   772 WMERGSR-SLPDSGRTSPCP--RDGE---WFIKMLRAEVEKLEHWCQQMEREAEDYE--LPEE-I 827

  Fly   611 IDMINVTIGQTRLLTTKKMMQFSGLIDRCEAGATGKNSQPNDGSEDSKPVQA-EDLEGWWDMLRL 674
            ::.|...:|.|:||.::|:.||..|   |:     ::..|.     :.||.. :||.|:||:|:|
  Rat   828 LEKIRSAVGSTQLLLSQKVQQFFRL---CQ-----QSLDPT-----AFPVPTFQDLAGFWDLLQL 879

  Fly   675 QSENVDKRFDNLKRWKANDW--LDPDAVAEEPKQPKP---KPKISRNMKIKSKAKPSSNLQ-QFL 733
            ..|:|..:|..|::.|||.|  |:|   .||.|.|.|   ||...|.:.:|.::..|.:.| |..
  Rat   880 SIEDVTLKFLELQQLKANSWKLLEP---KEEKKVPPPIPKKPSRGRGVPVKERSLDSVDRQRQEA 941

  Fly   734 RKAHANMKKTKVEEPTLEDGLPATSSRHSS 763
            ||.....|:             |.|.||||
  Rat   942 RKRLLAAKR-------------AASFRHSS 958

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mars	NP_001163142.1	GKAP	<558..>703	CDD:281368	44/147 (30%)
Dlgap3	NP_775161.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	52..90
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	137..167
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	181..289
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..417
		PHA03418	515..>607	CDD:177646	17/78 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	529..582		11/53 (21%)
		GKAP	626..977	CDD:397439	94/387 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	739..788		6/49 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	906..939		11/32 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3971
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12353
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910