DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mars and IL1RAPL2

DIOPT Version :9

Sequence 1:	NP_001163142.1	Gene:	mars / 36498	FlyBaseID:	FBgn0033845	Length:	921	Species:	Drosophila melanogaster
Sequence 2:	NP_059112.1	Gene:	IL1RAPL2 / 26280	HGNCID:	5997	Length:	686	Species:	Homo sapiens

Alignment Length:	211	Identity:	45/211 - (21%)
Similarity:	77/211 - (36%)	Gaps:	62/211 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 RLDTKPAELLKESNPKVSRQKLYLQRYMEWKIAKTKEHKQQDQKRRGAAINVPTVKQSKALPKSQ 143
            :::.:..|.||.|        :.|...::||.:|:.                   |.:....|..
Human   515 KVNCQEVESLKRS--------IKLLSLIKWKGSKSS-------------------KLNSKFWKHL 552

  Fly   144 TFRVPDNLASAKQKEAAPMFQPPKRCSLYMIANPTGKGKAAEPIKPSIPKPTSAAAPPSSNT--- 205
            .:.:|     .|:||..|      ||.:...|. .|.....:|| |||...:::|...||..
Human   553 VYEMP-----IKKKEMLP------RCHVLDSAE-QGLFGELQPI-PSIAMTSTSATLVSSQADLP 604

  Fly   206 --VAASSALARH-----KSAASATKI-VPAIRQN----NNPVALARQKAAARPIPNTTKQTTSVR 258
              ..:.|...||     |....||.: ||::..:    |.|:.|...:.   |:.||.|.|....
Human   605 EFHPSDSMQIRHCCRGYKHEIPATTLPVPSLGNHHTYCNLPLTLLNGQL---PLNNTLKDTQEFH 666

  Fly   259 QPG----IEAKKITTT 270
            :..    :.:|:::.|
Human   667 RNSSLLPLSSKELSFT 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mars	NP_001163142.1	GKAP	<558..>703	CDD:281368
IL1RAPL2	NP_059112.1	Ig	32..133	CDD:325142
		Ig2_IL1R_like	146..237	CDD:319309
		IG_like	250..347	CDD:214653
		TIR	402..563	CDD:307630	13/79 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3971
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900