Protein Alignment mars and Dlgap2

DIOPT Version :10

• Sequence 1: NP_610878.1
• Gene: mars / 36498
• FlyBaseID: FBgn0033845
• Length: 921
• Species: Drosophila melanogaster
• Sequence 2: NP_001139437.1
• Gene: Dlgap2 / 244310
• MGIID: 2443181
• Length: 1060
• Species: Mus musculus
• Alignment Length: 987
• Identity: 208/987 - (21%)
• Similarity: 319/987 - (32%)
• Gaps: 336/987 - (34%)

  Fly    17 PRNHCQENRDRLQAARAKKREDCFYQNRIISVSPTPVKI-----KQL------------AAAQAA 64
            ||.|...:.|        .|:||...:....|:..|..:     |||            ..|.||
Mouse   166 PRMHYSSHYD--------TRDDCAMSHTSTKVNRIPANLLDQFEKQLPLHRDGFHTLQYQRASAA 222

  Fly    65 LTQENVAP-----KLESPERLDTKPAELLKESNPKVSRQK----------LYLQRYMEWKIAKTK 114
            ..|.|.:|     .:.|.::|.||...|...|...::..|          .:|.::.  |.:|:|
Mouse   223 TEQRNESPGRIRHLVHSVQKLFTKSHSLEGSSKSNINGTKSDSRVDDHHQSHLSKHS--KRSKSK 285

  Fly   115 EHKQQDQKRRGAAINVPTVKQSKALPKSQTFRVP------------------------------- 148
            |.|.:.:.:.|.:   ........|....|:|.|
Mouse   286 ERKPESKHKSGMS---SWWSSDDNLDSDSTYRTPSVAHRHHMDHIPHCYPEALQSPFGDLSLKTS 347

  Fly   149 ----------------------------DNLASAKQKEA---------APMFQPPKRCSL----Y 172
                                        ..|..::.|||         .|:..|..:.||    |
Mouse   348 KSNNDVKCSACEGLALTPDTRYMKRSSWSTLTVSQAKEAYRKSSLNLDKPLVHPEIKPSLRPCHY 412

  Fly   173 MI-------ANPTGKGKAAE-PIK-------------------PSIPK--PTSAAAPPSSNTVAA 208
            :.       |.||| ||..| |.:                   .|.||  ||.|..|........
Mouse   413 LQVPQDDWGAYPTG-GKEEEIPCRRMRSGSYIKAMGDEESGESDSSPKTSPTVAIRPEPLLKPII 476

  Fly   209 SSALARHKSAA---SATKIV------PAIRQNNNPVALARQKAAARPIPNTTKQTTSVRQ----- 259
            ...|..|::.:   :||::.      |:|.. |:|...:|.::..|.: :|..|.:.|.|
Mouse   477 QRPLGDHQTQSYLQAATEVPVGHSLNPSINY-NSPKFRSRNQSYMRAV-STLSQASCVSQMSEAE 539

  Fly   260 --------------------------PG------------IEA--KKITTTIPRPTPATVTKAKT 284
                                      ||            |:|  .:....||..|.:.:|..
Mouse   540 VNGQFESVCESVFSEVESQAMDALDLPGCFRTRSHSYLRAIQAGYSQDDECIPVMTSSNMTST-- 602

  Fly   285 PGIRQQPPVVSTKPRLPEPPAPRTARLPNVLSKPFEKPLGNKAPVT-------RRANVVKPQPIR 342
              ||....|..|..:...||.|     |...|||........:..:       .||..:.|.|..
Mouse   603 --IRSTAAVSYTNYKKTPPPVP-----PRTTSKPLISVTAQSSTESTQDAYQDSRAQRMSPWPQD 660

  Fly   343 GGGGA--------AAKFKDTAGATSKAASHSIRMKATKIKSQYTRLQDNVRKLPQLKAELLHAAT 399
            ..||.        :.|..:.|..|:.|..|     |...:|..||..|.. .|.....|||.:..
Mouse   661 SRGGLYNSMDSLDSNKAMNLALETAAAQRH-----AADTQSSSTRSIDKA-VLASKAEELLKSRC 719

  Fly   400 LDIPPLTPLDDIHNPFIDQATSTQCKSNNSSGHLLEAFGDTILL-------------SPVAPVKA 451
            ..|.........|.|:......|...|:..|..|.|.....:.:             |..|.|:|
Mouse   720 SSIGVQDSEFPDHQPYPRSDVETATDSDTESRGLREYHSVGVQVEDEKRHGRFKRSNSVTAAVQA 784

  Fly   452 E-------GESSVKRQLLPEGKKEASGPVAKKKFDFTRYSVANSPAEDSLILDPQQT---TVKED 506
            :       |..|::.:.|..|.            .|.|:|..::|.:...:...:..   :.:||
Mouse   785 DLELEGFPGHVSMEDKGLQFGS------------SFQRHSEPSTPTQYGALRTVRTQGLFSYRED 837

  Fly   507 TGDSTLVPEGTKTPPRRESNGMPNYLSPFV-SVSRGKVNSRCEKEKRNSFYLSNEESPLEVRRAI 570
            .  .|.|...|..||       ..:|.|.: :|..|:: |.|.::  .|::|.
Mouse   838 Y--RTQVDTSTLPPP-------DPWLEPSLDTVETGRM-SPCRRD--GSWFLK------------ 878

  Fly   571 ESVLYFRLQLENEITRLQALCAEWEAYSKENEARLQETGGIDMINVTIGQTRLLTTKKMMQFSGL 635
                    .|..|..|::..|.|.|..::||:. |::..|  .|...:|..:||.::|..||..|
Mouse   879 --------LLHTETKRMEGWCKEMEREAEENDL-LEDILG--KIRSAVGSAQLLMSQKFQQFYWL 932

  Fly   636 IDRCEAGATGKNSQPNDGSEDSKPVQAEDLEGWWDMLRLQSENVDKRFDNLKRWKANDW--LDPD 698
               |:        |..|.|...:|. ::||.|:||||:|..|:|..:||.|.:.|.|||  ::..
Mouse   933 ---CQ--------QNMDPSAMPRPT-SQDLAGYWDMLQLSVEDVSMKFDELHQLKLNDWKIIESP 985

  Fly   699 AVAEEPKQPKPKPK--------ISRNMKIKSKAKPSSNLQQFLR-----KAHANMKKTKVEE--P 748
            ...||.|.|.|.||        |:|.   ||...|....|:..|     |..|:.::....|  .
Mouse   986 ERKEERKIPPPIPKKPPKGKFPITRE---KSLDLPDRQRQEARRRLMAAKRAASFRQNSATERAD 1047

  Fly   749 TLEDGLPATSSR 760
            ::|..:|...:|
Mouse  1048 SIEIYIPEAQTR 1059

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mars	NP_610878.1	PHA03247	<131..342	CDD:223021	65/372 (17%)
		GKAP	<580..>694	CDD:460897	38/113 (34%)
Dlgap2	NP_001139437.1	GKAP	716..1060	CDD:460897	95/406 (23%)