DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mars and DLGAP4

DIOPT Version :9

Sequence 1:	NP_001163142.1	Gene:	mars / 36498	FlyBaseID:	FBgn0033845	Length:	921	Species:	Drosophila melanogaster
Sequence 2:	NP_001352550.1	Gene:	DLGAP4 / 22839	HGNCID:	24476	Length:	992	Species:	Homo sapiens

Alignment Length:	877	Identity:	184/877 - (20%)
Similarity:	305/877 - (34%)	Gaps:	294/877 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 AKTKEHKQQDQKRRGAAINVPTVKQSKALPKSQTFRVPDNL------------AS-----AKQKE 158
            ||:||..:..:.:|.:..|:           |..:...|||            ||     .:|.|
Human   182 AKSKERAKAGEPKRRSRSNI-----------SGWWSSDDNLDGEAGAFRSSGPASGLMTLGRQAE 235

  Fly   159 AAPMFQPPKRCSLYMIANPTGKGKAAEPIKPSIPKPTSAAAPP---------------------S 202
            .:   ||    ..:|.|..|..|...:..|.:..:.|:...||                     |
Human   236 RS---QP----RYFMHAYNTISGHMLKTTKNNTTELTAPPPPPAPPATCPSLGVGTDTNYVKRGS 293

  Fly   203 SNTVAASSALARHK--SAASATKIVPAIRQNNNPVALA----------------------RQKAA 243
            .:|:..|.|   |:  ...|||.....::..:....||                      ...||
Human   294 WSTLTLSHA---HEVCQKTSATLDKSLLKSKSCHQGLAYHYLQVPGGGGEWSTTLLSPRETDAAA 355

  Fly   244 ARPIPNTTKQTTS-VRQPGIEAKKITTTIPRPTPATVTKAKTPGIRQQPPVVSTKPRLPEPPAPR 307
            ..|||....::.| ::..|.|....:...|:|:|.|..       |:|..:.:|:..|.|...||
Human   356 EGPIPCRRMRSGSYIKAMGDEDSDESGGSPKPSPKTAA-------RRQSYLRATQQSLGEQSNPR 413

  Fly   308 TA--RLPNV----LSK---------PFEKPLGNKAPVTR---RANVV-----KPQPIRGG----- 344
            .:  ||.:|    .||         |....|.:.:.:::   :|:::     ..|.:|..
Human   414 RSLDRLDSVDMLLPSKCPSWEEDYTPVSDSLNDSSCISQIFGQASLIPQLFGHEQQVREAELSDQ 478

  Fly   345 -----GGAAAKFKDTAGAT--------SKAASHSIRMKATKIKSQYTRLQDNV------------ 384
                 ..|.::.:.||..|        .::.|||. ::|  |::..::.:|:|
Human   479 YEAACESACSEAESTAAETLDLPLPSYFRSRSHSY-LRA--IQAGCSQEEDSVSLQSLSPPPSTG 540

  Fly   385 -----RKLPQLKAELLHAATLDIPPLTPLDDIHNPFIDQATSTQCKSN-----NSSGHLLEAFGD 439
                 |.||.....:.:..|   ||..|......|||.....:..:|.     :|..|..|....
Human   541 SLSNSRTLPSSSCLVAYKKT---PPPVPPRTTSKPFISVTVQSSTESAQDTYLDSQDHKSEVTSQ 602

  Fly   440 T----------------------ILLSPVAP--------VKAE----------GESSVKRQLLPE 464
            :                      :..:|.||        :|:|          .|::.||:|...
Human   603 SGLSNSSDSLDSSTRPPSVTRGGVAPAPEAPEPPPKHAALKSEQGTLTSSESHPEAAPKRKLSSI 667

  Fly   465 G-KKEASGPVAKKK-FDFTRYSVANSPAED-----------SLILDPQQTTVKEDTGDSTLVPEG 516
            | :.:...||.|:: ...|::.......||           |...|....|  :|..||:.....
Human   668 GIQVDCIQPVPKEEPSPATKFQSIGVQVEDDWRSSVPSHSMSSRRDTDSDT--QDANDSSCKSSE 730

  Fly   517 TKTPPRRESNGMPNYLSPFVSVSRG-KVNSRCEKEKRNSFYLSNEESPLEV-------------- 566
            ...|   :....||    .:|:..| :...:..:.|||..|..|.:..||.
Human   731 RSLP---DCTPHPN----SISIDAGPRQAPKIAQIKRNLSYGDNSDPALEASSLPPPDPWLETSS 788

  Fly   567 ------------RRAIESVLYFRLQLENEITRLQALCAEWEAYSKENEARLQETGGIDMINVTIG 619
                        ||  :...:.:| |:.|..||:..|.:.:..:|||....:..|   .:...:|
Human   789 SSPAEPAQPGACRR--DGYWFLKL-LQAETERLEGWCCQMDKETKENNLSEEVLG---KVLSAVG 847

  Fly   620 QTRLLTTKKMMQFSGLIDRCEAGATGKNSQPNDGSEDSKP-VQAEDLEGWWDMLRLQSENVDKRF 683
            ..:||.::|..||.||   ||     :|..|     |:.| ..|:||.|:||:|:|..|::..:|
Human   848 SAQLLMSQKFQQFRGL---CE-----QNLNP-----DANPRPTAQDLAGFWDLLQLSIEDISMKF 899

  Fly   684 DNLKRWKANDWL---DPDAVAEEPKQPKP--------KPKISRNMKIKSKAKPSSNLQQ------ 731
            |.|...|||.|.   .|:...||.|.|.|        ||.:||:     ||..:|:.|:
Human   900 DELYHLKANSWQLVETPEKRKEEKKPPPPVPKKPAKSKPAVSRD-----KASDASDKQRQEARKR 959

  Fly   732 -FLRKAHANMKKTKVEE--PTLEDGLPATSSR 760
             ...|..|::::....|  .::|..:|...:|
Human   960 LLAAKRAASVRQNSATESADSIEIYVPEAQTR 991

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mars	NP_001163142.1	GKAP	<558..>703	CDD:281368	46/174 (26%)
DLGAP4	NP_001352550.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	47..66
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..206		7/34 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	342..396		13/60 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	527..751		42/235 (18%)
		GKAP	660..992	CDD:308780	90/365 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	763..798		4/34 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	915..992		20/82 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9732
eggNOG	1	0.900	-	-		E1_KOG3971
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12353
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910