DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mars and il1rapl2

DIOPT Version :9

Sequence 1:	NP_001163142.1	Gene:	mars / 36498	FlyBaseID:	FBgn0033845	Length:	921	Species:	Drosophila melanogaster
Sequence 2:	NP_001136056.1	Gene:	il1rapl2 / 100149452	ZFINID:	ZDB-GENE-040219-5	Length:	681	Species:	Danio rerio

Alignment Length:	273	Identity:	54/273 - (19%)
Similarity:	84/273 - (30%)	Gaps:	104/273 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   430 SGHLLEAFGDTILLSPVAPVKAEGESS---------------VKRQLLPEGKKE----ASGPVAK 475
            |||.|...||:|...     .||.|.:               |...|..|..:|    :|....:
Zfish    90 SGHRLSKEGDSIWFR-----SAEMEDNGFYTCVLRNSTYCMKVSMSLTVEESEEGLCFSSRIRYQ 149

  Fly   476 KKFDFTRYSVANSPAEDSLIL---DPQQTTVKE---DTGDSTLVPEGTK--TPPRRESNGMPNYL 532
            ::.:.|:..:.:.|..|..:.   .|..|..||   ....|:::...|.  .|..:|.:| .||
Zfish   150 ERAEITKSKMISCPDIDDYLAPYKQPIMTWYKECQRKEWRSSIIINTTSLWIPEVQEDDG-GNY- 212

  Fly   533 SPFVSVSRGKVNSRCEKEKRNSFYLSNEESPLEVRRAIESVLYFRLQLENEITRLQALCAEWEAY 597
                         .||.:..:..          |||..|.          ::|.|.........:
Zfish   213 -------------TCELKYGSKV----------VRRTTEL----------KVTALLTTRPPKVLF 244

  Fly   598 SKENEARLQETGGIDMINVTIGQTRLLTTKKMMQFSGLIDRCEAGATGKNSQPNDGSEDSKPV-- 660
            ..|.:|        .:|:|.:|...:|..|....:||                     ||||:
Zfish   245 PSERQA--------SVIDVQLGMRLILDCKAFFGYSG---------------------DSKPIIY 280

  Fly   661 ------QAEDLEG 667
                  ..|:|||
Zfish   281 WMKGDKFVEELEG 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mars	NP_001163142.1	GKAP	<558..>703	CDD:281368	23/118 (19%)
il1rapl2	NP_001136056.1	Ig	32..133	CDD:299845	12/47 (26%)
		IG_like	39..133	CDD:214653	12/47 (26%)
		Ig	146..232	CDD:299845	20/120 (17%)
		IG_like	160..231	CDD:214653	19/105 (18%)
		I-set	247..347	CDD:254352	17/76 (22%)
		Ig	253..347	CDD:299845	15/62 (24%)
		TIR	400..558	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3971
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900