DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment drk and Src

DIOPT Version :9

Sequence 1:	NP_476858.1	Gene:	drk / 36497	FlyBaseID:	FBgn0004638	Length:	211	Species:	Drosophila melanogaster
Sequence 2:	NP_114183.1	Gene:	Src / 83805	RGDID:	620795	Length:	542	Species:	Rattus norvegicus

Alignment Length:	220	Identity:	63/220 - (28%)
Similarity:	108/220 - (49%)	Gaps:	43/220 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IAKHDFSATADDELSFRKTQILKILNME-----DDSNWYRAE--LDGKEGLIPSNYI----EMKN 57
            :|.:|:.:..:.:|||:|.:.|:|:|..     .:.:|:.|.  ..|:.|.|||||:    .::.
  Rat    90 VALYDYESRTETDLSFKKGERLQIVNNTRKVDVREGDWWLAHSLSTGQTGYIPSNYVAPSDSIQA 154

  Fly    58 HDWYYGRITRADAEKLLSNKH--EGAFLIRISESSPGDFSLSVKCPD-----GVQHFKVLRDAQS 115
            .:||:|:|||.::|:||.|..  .|.||:|.||::.|.:.|||...|     .|:|:|:.:....
  Rat   155 EEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSG 219

  Fly   116 KFFLWV-VKFNSLNELVEY---------HRTASVSRSQDVKLRDMIPEEMLVQALYDFVPQESGE 170
            .|::.. .:||||.:||.|         ||..:|..:...:.:.:..:..       .:|:||..
  Rat   220 GFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAW-------EIPRESLR 277

  Fly   171 LDFRRGDVITVTDRSDENW---WNG 192
            |:.:.|.     ....|.|   |||
  Rat   278 LEVKLGQ-----GCFGEVWMGTWNG 297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drk	NP_476858.1	SH3_GRB2_like_N	2..53	CDD:212738	17/55 (31%)
		SH2_Grb2_like	56..149	CDD:199828	35/109 (32%)
		SH3_GRB2_like_C	156..208	CDD:212739	10/40 (25%)
Src	NP_114183.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..49
		SH3_Src	88..149	CDD:212941	18/58 (31%)
		SH2_Src_Src	153..253	CDD:198228	34/99 (34%)
		PTKc_Src	266..542	CDD:270656	10/44 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910