Protein Alignment drk and Grb2

DIOPT Version :10

• Sequence 1: NP_476858.1
• Gene: drk / 36497
• FlyBaseID: FBgn0004638
• Length: 211
• Species: Drosophila melanogaster
• Sequence 2: NP_110473.2
• Gene: Grb2 / 81504
• RGDID: 619758
• Length: 217
• Species: Rattus norvegicus
• Alignment Length: 212
• Identity: 139/212 - (65%)
• Similarity: 167/212 - (78%)
• Gaps: 4/212 - (1%)

  Fly     1 MEAIAKHDFSATADDELSFRKTQILKILNMEDDSNWYRAELDGKEGLIPSNYIEMKNHDWYYGRI 65
            ||||||:||.|||||||||::..|||:||.|.|.|||:|||:||:|.||.||||||.|.|::|:|
  Rat     1 MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKI 65

  Fly    66 TRADAEKLLS-NKHEGAFLIRISESSPGDFSLSVKCPDGVQHFKVLRDAQSKFFLWVVKFNSLNE 129
            .||.||::|| .:|:||||||.|||:|||||||||..:.|||||||||...|:||||||||||||
  Rat    66 PRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNE 130

  Fly   130 LVEYHRTASVSRSQDVKLRDM--IPEE-MLVQALYDFVPQESGELDFRRGDVITVTDRSDENWWN 191
            ||:|||:.||||:|.:.|||:  :|:: ..||||:||.|||.|||.|||||.|.|.|.||.|||.
  Rat   131 LVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWK 195

  Fly   192 GEIGNRKGIFPATYVTP 208
            |....:.|:||..||||
  Rat   196 GACHGQTGMFPRNYVTP 212

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drk	NP_476858.1	SH3_GRB2_like_N	2..53	CDD:212738	35/50 (70%)
		SH2_Grb2_like	56..149	CDD:199828	63/93 (68%)
		SH3_GRB2_like_C	156..208	CDD:212739	31/51 (61%)
Grb2	NP_110473.2	SH3_GRB2_N	1..56	CDD:212879	39/54 (72%)
		SH2_Grb2_like	56..150	CDD:199828	63/93 (68%)
		SH3_GRB2_C	160..212	CDD:212882	31/51 (61%)