DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment drk and Sla2

DIOPT Version :9

Sequence 1:	NP_476858.1	Gene:	drk / 36497	FlyBaseID:	FBgn0004638	Length:	211	Species:	Drosophila melanogaster
Sequence 2:	XP_011238147.1	Gene:	Sla2 / 77799	MGIID:	1925049	Length:	274	Species:	Mus musculus

Alignment Length:	159	Identity:	49/159 - (30%)
Similarity:	80/159 - (50%)	Gaps:	31/159 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AIAKHDFSATADDELSFRKTQILKILNMEDDSNWY--RAELDGKEGLIPSNYIEMKNHDWYYGRI 65
            |:|...|.|.....||.|..:.|.|::  :|.:|:  ::|:.|:|..:||.|:....|.|.|..:
Mouse    36 AVALGSFPAGEQARLSLRLGEPLTIIS--EDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGL 98

  Fly    66 TRADAEK--LLSNKHEGAFLIRISE---------------SSPGDFSLSVKCP-----DGVQHFK 108
            :|..||:  ||.....||||||.|:               ||.|.:||||:..     |.::|::
Mouse    99 SREKAEELLLLPGNPGGAFLIRESQTRRGLSLYLDPPWTLSSLGCYSLSVRLSRPASWDRIRHYR 163

  Fly   109 VLRDAQSKFFLWV---VKFNSLNELVEYH 134
            :.|  ....:|::   :.|.||:.|||::
Mouse   164 IQR--LDNGWLYISPRLTFPSLHALVEHY 190

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drk	NP_476858.1	SH3_GRB2_like_N	2..53	CDD:212738	16/51 (31%)
		SH2_Grb2_like	56..149	CDD:199828	32/104 (31%)
		SH3_GRB2_like_C	156..208	CDD:212739
Sla2	XP_011238147.1	SH3	35..89	CDD:388381	17/54 (31%)
Sla2	XP_011238147.1	SH2	82..200	CDD:387587	35/111 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910