DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment drk and YES1

DIOPT Version :9

Sequence 1:	NP_476858.1	Gene:	drk / 36497	FlyBaseID:	FBgn0004638	Length:	211	Species:	Drosophila melanogaster
Sequence 2:	NP_005424.1	Gene:	YES1 / 7525	HGNCID:	12841	Length:	543	Species:	Homo sapiens

Alignment Length:	211	Identity:	61/211 - (28%)
Similarity:	111/211 - (52%)	Gaps:	31/211 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IAKHDFSATADDELSFRKTQILKILNMEDDSNWYRAE--LDGKEGLIPSNYI----EMKNHDWYY 62
            :|.:|:.|...::|||:|.:..:|:| ..:.:|:.|.  ..||.|.|||||:    .::..:||:
Human    97 VALYDYEARTTEDLSFKKGERFQIIN-NTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYF 160

  Fly    63 GRITRADAEKLLSN--KHEGAFLIRISESSPGDFSLSVK-----CPDGVQHFKVLRDAQSKFFLW 120
            |::.|.|||:||.|  ...|.||:|.||::.|.:|||::     ..|.|:|:|:.:.....:::.
Human   161 GKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYIT 225

  Fly   121 V-VKFNSLNELVEYHRTASVSRSQDVKLRDMIP-----EEMLVQALYDFVPQESGELDFRRGDVI 179
            . .:|::|.:||:::...:.....  ||..:.|     .:.|.:..:: :|:||..|:.:.|.
Human   226 TRAQFDTLQKLVKHYTEHADGLCH--KLTTVCPTVKPQTQGLAKDAWE-IPRESLRLEVKLGQ-- 285

  Fly   180 TVTDRSDENW---WNG 192
               ....|.|   |||
Human   286 ---GCFGEVWMGTWNG 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drk	NP_476858.1	SH3_GRB2_like_N	2..53	CDD:212738	18/50 (36%)
		SH2_Grb2_like	56..149	CDD:199828	30/100 (30%)
		SH3_GRB2_like_C	156..208	CDD:212739	11/40 (28%)
YES1	NP_005424.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..45
		SH3_Yes	94..151	CDD:212940	19/54 (35%)
		SH2_Src_family	154..253	CDD:199827	30/100 (30%)
		PTKc_Yes	264..542	CDD:270654	11/41 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910