DRSC/TRiP Functional Genomics Resources

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Protein Alignment drk and TXK

DIOPT Version :10

Sequence 1:NP_476858.1 Gene:drk / 36497 FlyBaseID:FBgn0004638 Length:211 Species:Drosophila melanogaster
Sequence 2:XP_024309968.1 Gene:TXK / 7294 HGNCID:12434 Length:530 Species:Homo sapiens


Alignment Length:148 Identity:44/148 - (29%)
Similarity:72/148 - (48%) Gaps:21/148 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 AKHDFSATADDELSFRKTQILKILNMEDDSNWYRAELDGKEGLIPSNYI------EMKNHDWYYG 63
            |.:||.......|:.|:.:...||...:...|...:..|.||||||||:      .::.::||:.
Human    92 ALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARDRLGNEGLIPSNYVTENKITNLEIYEWYHR 156

  Fly    64 RITRADAEKLL-SNKHEGAFLIRISESSPGDFSLSV------KCPDGVQHFKVLRDAQSKFFLWV 121
            .|||..||.|| ....||||::|.|... |.:::||      .....::|:::.::...:   |.
Human   157 NITRNQAEHLLRQESKEGAFIVRDSRHL-GSYTISVFMGARRSTEAAIKHYQIKKNDSGQ---WY 217

  Fly   122 V----KFNSLNELVEYHR 135
            |    .|.|:.||:.||:
Human   218 VAERHAFQSIPELIWYHQ 235

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
drkNP_476858.1 SH3_GRB2_like_N 2..53 CDD:212738 16/47 (34%)
SH2_Grb2_like 56..149 CDD:199828 27/91 (30%)
SH3_GRB2_like_C 156..208 CDD:212739
TXKXP_024309968.1 SH3_TXK 88..142 CDD:212840 17/49 (35%)
SH2_Tec_Txk 146..251 CDD:198261 27/94 (29%)
PTKc_Tec_like 269..524 CDD:173637
Blue background indicates that the domain is not in the aligned region.

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