DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment drk and SH3GL1

DIOPT Version :9

Sequence 1:	NP_476858.1	Gene:	drk / 36497	FlyBaseID:	FBgn0004638	Length:	211	Species:	Drosophila melanogaster
Sequence 2:	NP_003016.1	Gene:	SH3GL1 / 6455	HGNCID:	10830	Length:	368	Species:	Homo sapiens

Alignment Length:	249	Identity:	60/249 - (24%)
Similarity:	97/249 - (38%)	Gaps:	73/249 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 RKTQILKILNMEDDSNWYRAELDGKEGLIPSNYIEMKNH---------DWYY-----GRITRADA 70
            |..::...|::|...|:    :|..:.|...:..|:::|         |:.|     |:|...:.
Human   123 RLAEVKDSLDIEVKQNF----IDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQGKIPDEEL 183

  Fly    71 EKLLSNKHEGAFLIRISESSPGDFSLSVKCPDGVQHFKVLRDAQSKFFLWVVKFNSLNELVEYHR 135
            .:.|....|..   .::|:|.  .:|.....:.|.....|.|||..:....|:.  |:||.|..:
Human   184 RQALEKFEESK---EVAETSM--HNLLETDIEQVSQLSALVDAQLDYHRQAVQI--LDELAEKLK 241

  Fly   136 -------------------------------------------TASVSRSQDVKL----RDMIP- 152
                                                       .:|..||.|..:    |.|.|
Human   242 RRMREASSRPKREYKPKPREPFDLGEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRTPSRSMPPL 306

  Fly   153 EEMLVQALYDFVPQESGELDFRRGDVITVTDRSDENWWNGEIGNRKGIFPATYV 206
            ::...:|||||.|:..|||.|..|||||:|::.||||:.|.:..:.|.||.:||
Human   307 DQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYV 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drk	NP_476858.1	SH3_GRB2_like_N	2..53	CDD:212738	6/32 (19%)
		SH2_Grb2_like	56..149	CDD:199828	24/153 (16%)
		SH3_GRB2_like_C	156..208	CDD:212739	26/51 (51%)
SH3GL1	NP_003016.1	Membrane-binding amphipathic helix. /evidence=ECO:0000250	1..21
		BAR_Endophilin_A	25..247	CDD:153276	27/134 (20%)
		Required for dimerization upon membrane association. /evidence=ECO:0000250	60..87
		Interaction with ARC. /evidence=ECO:0000250	218..254		9/37 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	244..308		7/63 (11%)
		SH3_Endophilin_A	309..363	CDD:212737	26/52 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R571
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030