DRSC/TRiP Functional Genomics Resources

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Protein Alignment drk and BLK

DIOPT Version :10

Sequence 1:NP_476858.1 Gene:drk / 36497 FlyBaseID:FBgn0004638 Length:211 Species:Drosophila melanogaster
Sequence 2:XP_011542126.1 Gene:BLK / 640 HGNCID:1057 Length:531 Species:Homo sapiens


Alignment Length:147 Identity:49/147 - (33%)
Similarity:81/147 - (55%) Gaps:21/147 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 IAKHDFSATADDELSFRKTQILKILNMEDDSNWY--RAELDGKEGLIPSNYI------EMKNHDW 60
            :|.:|::|..|.:|...|.:.|::|....|  |:  |:.:.|:||.:|||::      ||:.  |
Human    64 VALYDYTAMNDRDLQMLKGEKLQVLKGTGD--WWLARSLVTGREGYVPSNFVARVESLEMER--W 124

  Fly    61 YYGRITRADAEKLL---SNKHEGAFLIRISESSPGDFSLSVK--CPDG--VQHFKV-LRDAQSKF 117
            ::....|.:||:.|   .|| .|:||||.||::.|.||||||  ...|  ::|:|: ..|....:
Human   125 FFRSQGRKEAERQLLAPINK-AGSFLIRESETNKGAFSLSVKDVTTQGELIKHYKIRCLDEGGYY 188

  Fly   118 FLWVVKFNSLNELVEYH 134
            ....:.|.||..||:::
Human   189 ISPRITFPSLQALVQHY 205

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
drkNP_476858.1 SH3_GRB2_like_N 2..53 CDD:212738 17/50 (34%)
SH2_Grb2_like 56..149 CDD:199828 30/87 (34%)
SH3_GRB2_like_C 156..208 CDD:212739
BLKXP_011542126.1 SH3_Blk 62..115 CDD:212942 17/52 (33%)
SH2_Src_Blk 120..219 CDD:198234 32/89 (36%)
Protein Kinases, catalytic domain 233..522 CDD:473864
Blue background indicates that the domain is not in the aligned region.

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